In the field of molecular evolution, inferences about past evolutionary events are made using molecular data from currently living species. With the availability of genomic data from multiple related species, molecular evolution has become one of the most active and fastest growing fields of study in genomics and bioinformatics.

Most studies in molecular evolution rely heavily on statistical procedures based on stochastic process modelling and advanced computational methods including high-dimensional numerical optimization and Markov Chain Monte Carlo. This book provides an overview of the statistical theory and methods used in studies of molecular evolution. It includes an introductory section suitable for readers that are new to the field, a section discussing practical methods for data analysis, and more specialized sections discussing specific models and addressing statistical issues relating to estimation and model choice. The chapters are written by the leaders of field and they will take the reader from basic introductory material to the state-of-the-art statistical methods.

This book is suitable for statisticians seeking to learn more about applications in molecular evolution and molecular evolutionary biologists with an interest in learning more about the theory behind the statistical methods applied in the field. The chapters of the book assume no advanced mathematical skills beyond basic calculus, although familiarity with basic probability theory will help the reader. Most relevant statistical concepts are introduced in the book in the context of their application in molecular evolution, and the book should be accessible for most biology graduate students with an interest in quantitative methods and theory.

Rasmus Nielsen received his Ph.D. form the University of California at Berkeley in 1998 and after a postdoc at Harvard University, he assumed a faculty position in Statistical Genomics at Cornell University. He is currently an Ole Romer Fellow at the University of Copenhagen and holds a Sloan Research Fellowship. His is an associate editor of the Journal of Molecular Evolution and has published more than fifty original papers in peer-reviewed journals on the topic of this book.

From the reviews:

..".Overall this is a very useful book in an area of increasing importance." Journal of the Royal Statistical Society

"I find Statistical Methods in Molecular Evolution very interesting and useful. It delves into problems that were considered very difficult just several years ago...the book is likely to stimulate the interest of statisticians that are unaware of this exciting field of applications. It is my hope that it will also help the 'wet lab' molecular evolutionist to better understand mathematical and statistical methods." Marek Kimmel for the Journal of the American Statistical Association, September 2006

"Who should read this book? We suggest that anyone who deals with molecular data (who does not?) and anyone who asks evolutionary questions (who should not?) ought to consult the relevant chapters in this book." Dan Graur and Dror Berel for Biometrics, September 2006

"Coalescence theory facilitates the merger of population genetics theory with phylogenetic approaches, but still, there are mostly two camps: phylogeneticists and population geneticists. Only a few people are moving freely between them. Rasmus Nielsen is certainly one of these researchers, and his work so far has merged many population genetic and phylogenetic aspects of biological research under the umbrella of molecular evolution. Although Nielsen did not contribute a chapter to his book, his work permeates all its chapters. This book gives an overview of his interests and current achievements in molecular evolution. In short, this book should be on your bookshelf." Peter Beerli for Evolution, 60(2), 2006"

Improving the quality of products and manufacturing processes at low cost is an economic and technological challenge to industrial engineers and managers alike. In today's business world, the implementation of experimental design techniques often falls short of the mark due to a lack of statistical knowledge on the part of engineers and managers in their analyses of manufacturing process quality problems. This timely book aims to fill this gap in the statistical knowledge required by engineers to solve manufacturing quality problems by using Taguchi experimental design methodology. The book increases awareness of strategic methodology through real-life case studies, providing valuable information for both academics and professionals with no prior knowledge of the theory of probability and statistics. Experimental Quality: Provides a unique framework to help engineers and managers address quality problems and use strategic design methodology. Offers detailed case studies illustrating the implementation of experimental design theory. Is easily accessible without prior knowledge or understanding of probability and statistics. This book provides an excellent resource for both academic and industrial environments, and will prove invaluable to practising industrial engineers, quality engineers and engineering managers from all disciplines.

Nonlinear statistical modelling is an area of growing importance. This monograph presents mostly new results and methods concerning the nonlinear regression model. Among the aspects which are considered are linear properties of nonlinear models, multivariate nonlinear regression, intrinsic and parameter effect curvature, algorithms for calculating the L2-estimator and both local and global approximation. In addition to this a chapter has been added on the large topic of nonlinear exponential families. The volume will be of interest to both experts in the field of nonlinear statistical modelling and to those working in the identification of models and optimization, as well as to statisticians in general.

This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology. Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use. The authors are current or former members of the Biometric Research Branch at the National Cancer Institute.  They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools.

Self-contained chapters on the most important applications and methodologies in finance, which can easily be used for the reader’s research or as a reference for courses on empirical finance. Each chapter is reproducible in the sense that the reader can replicate every single figure, table, or number by simply copy-pasting the code we provide. A full-fledged introduction to machine learning with tidymodels based on tidy principles to show how factor selection and option pricing can benefit from Machine Learning methods. Chapter 2 on accessing & managing financial data shows how to retrieve and prepare the most important datasets in the field of financial economics: CRSP and Compustat. The chapter also contains detailed explanations of the most important data characteristics. Each chapter provides exercises that are based on established lectures and exercise classes and which are designed to help students to dig deeper. The exercises can be used for self-studying or as source of inspiration for teaching exercises.

Appropriate for a one-semester course, this self-contained book is an introduction to nonparametric curve estimation theory. It may be used for teaching graduate students in statistics (in this case an intermediate statistical inference, on the level of the book by G. Casella and R. Berger (1990) "Statistical Inference", Brooks/Cole, is the prerequisite) as well as for diverse classes with students from other sciences including engineering, business, social, medical, and biology.

Intended as a textbook for students taking a first graduate course in the subject, as well as for the general reference of interested research workers, this text discusses, in a readable form, developments from recently published work on certain broad topics not otherwise easily accessible, such as robust inference and the use of the bootstrap in a multivariate setting. A minimum background expected of the reader would include at least two courses in mathematical statistics, and certainly some exposure to the calculus of several variables together with the descriptive geometry of linear algebra.

This book is a collection of original research and survey articles on mathematical inequalities and their numerous applications in diverse areas of mathematics and engineering. It includes chapters on convexity and related concepts; inequalities for mean values, sums, functions, operators, functionals, integrals and their applications in various branches of mathematics and related sciences; fractional integral inequalities; and weighted type integral inequalities. It also presents their wide applications in biomathematics, boundary value problems, mechanics, queuing models, scattering, and geomechanics in a concise, but easily understandable way that makes the further ramifications and future directions clear. The broad scope and high quality of the contributions make this book highly attractive for graduates, postgraduates and researchers. All the contributing authors are leading international academics, scientists, researchers and scholars.

S. Panchapakesan has made significant contributions to ranking and selection and has published in many other areas of statistics, including order statistics, reliability theory, stochastic inequalities, and inference. Written in his honor, the twenty invited articles in this volume reflect recent advances in these areas and form a tribute to Panchapakesan 's influence and impact on these areas.

Featuring theory, methods, applications, and extensive bibliographies with special emphasis on recent literature, this comprehensive reference work will serve researchers, practitioners, and graduate students in the statistical and applied mathematics communities.

Applied Probability and Stochastic Processes is an edited work written in honor of Julien Keilson. This volume has attracted a host of scholars in applied probability, who have made major contributions to the field, and have written survey and state-of-the-art papers on a variety of applied probability topics, including, but not limited to: perturbation method, time reversible Markov chains, Poisson processes, Brownian techniques, Bayesian probability, optimal quality control, Markov decision processes, random matrices, queueing theory and a variety of applications of stochastic processes. The book has a mixture of theoretical, algorithmic, and application chapters providing examples of the cutting-edge work that Professor Keilson has done or influenced over the course of his highly-productive and energetic career in applied probability and stochastic processes. The book will be of interest to academic researchers, students, and industrial practitioners who seek to use the mathematics of applied probability in solving problems in modern society.

This volume introduces the statistical, methodological, and conceptual aspects of mediation analysis. Applications from health, social, and developmental psychology, sociology, communication, exercise science, and epidemiology are emphasized throughout. Single-mediator, multilevel, and longitudinal models are reviewed. The author's goal is to help the reader apply mediation analysis to their own data and understand its limitations.

Each chapter features an overview, numerous worked examples, a summary, and exercises (with answers to the odd numbered questions). The accompanying CD contains outputs described in the book from SAS, SPSS, LISREL, EQS, MPLUS, and CALIS, and a program to simulate the model. The notation used is consistent with existing literature on mediation in psychology.

The book opens with a review of the types of research questions the mediation model addresses. Part II describes the estimation of mediation effects including assumptions, statistical tests, and the construction of confidence limits. Advanced models including mediation in path analysis, longitudinal models, multilevel data, categorical variables, and mediation in the context of moderation are then described. The book closes with a discussion of the limits of mediation analysis, additional approaches to identifying mediating variables, and future directions.

Introduction to Statistical Mediation Analysis is intended for researchers and advanced students in health, social, clinical, and developmental psychology as well as communication, public health, nursing, epidemiology, and sociology. Some exposure to a graduate level research methods or statistics course is assumed. The overview of mediationanalysis and the guidelines for conducting a mediation analysis will be appreciated by all readers.

This volume collects thirteen expository or survey articles on topics including Fractal Geometry, Analysis of Fractals, Multifractal Analysis, Ergodic Theory and Dynamical Systems, Probability and Stochastic Analysis, written by the leading experts in their respective fields. The articles are based on papers presented at the International Conference on Advances on Fractals and Related Topics, held on December 10-14, 2012 at the Chinese University of Hong Kong. The volume offers insights into a number of exciting, cutting-edge developments in the area of fractals, which has close ties to and applications in other areas such as analysis, geometry, number theory, probability and mathematical physics.

Filling the need for a comprehensive guide on the subject, Applied Time Series Analysis for the Social Sciences presents time series analysis in an accessible format designed to appeal to students and professional researchers with little mathematical and statistical background. With a focus on social-science applications and a mix of theory, including detailed case studies provided throughout, the text examines various uses and interpretations of lagged dependent variables and common confusion in this area. An accompanying website with data sets and examples in Stats and R accompanies the text.

This book examines information processing performed by bio-systems at all scales: from genomes, cells and proteins to cognitive and even social systems. It introduces a theoretical/conceptual principle based on quantum information and non-Kolmogorov probability theory to explain information processing phenomena in biology as a whole. The book begins with an introduction followed by two chapters devoted to fundamentals, one covering classical and quantum probability, which also contains a brief introduction to quantum formalism, and another on an information approach to molecular biology, genetics and epigenetics. It then goes on to examine adaptive dynamics, including applications to biology, and non-Kolmogorov probability theory. Next, the book discusses the possibility to apply the quantum formalism to model biological evolution, especially at the cellular level: genetic and epigenetic evolutions. It also presents a model of the epigenetic cellular evolution based on the mathematical formalism of open quantum systems. The last two chapters of the book explore foundational problems of quantum mechanics and demonstrate the power of usage of positive operator valued measures (POVMs) in biological science. This book will appeal to a diverse group of readers including experts in biology, cognitive science, decision making, sociology, psychology, and physics; mathematicians working on problems of quantum probability and information and researchers in quantum foundations.

Since their first introduction in natural sciences through the work of Einstein on Brownian motion in 1905 and further works, in particular by Langevin, Smoluchowski and others, stochastic processes have been used in several areas of science and technology. For example, they have been applied in chemical studies, or in fluid turbulence and for combustion and reactive flows. The articles in this book provide a general and unified framework in which stochastic processes are presented as modeling tools for various issues in engineering, physics and chemistry, with particular focus on fluid mechanics and notably dispersed two-phase flows. The aim is to develop what can referred to as stochastic modeling for a whole range of applications.

Mathematical Statistics for Economics and Business, Second Edition, provides a comprehensive introduction to the principles of mathematical statistics which underpin statistical analyses in the fields of economics, business, and econometrics. The selection of topics in this textbook is designed to provide students with a conceptual foundation that will facilitate a substantial understanding of statistical applications in these subjects. This new edition has been updated throughout and now also includes a downloadable Student Answer Manual containing detailed solutions to half of the over 300 end-of-chapter problems. After introducing the concepts of probability, random variables, and probability density functions, the author develops the key concepts of mathematical statistics, most notably: expectation, sampling, asymptotics, and the main families of distributions. The latter half of the book is then devoted to the theories of estimation and hypothesis testing with associated examples and problems that indicate their wide applicability in economics and business. Features of the new edition include: a reorganization of topic flow and presentation to facilitate reading and understanding; inclusion of additional topics of relevance to statistics and econometric applications; a more streamlined and simple-to-understand notation for multiple integration and multiple summation over general sets or vector arguments; updated examples; new end-of-chapter problems; a solution manual for students; a comprehensive answer manual for instructors; and a theorem and definition map. This book has evolved from numerous graduate courses in mathematical statistics and econometrics taught by the author, and will be ideal for students beginning graduate study as well as for advanced undergraduates.

The standard approach of most introductory books for practical statistics is that readers first learn the minimum mathematical basics of statistics and rudimentary concepts of statistical methodology. They then are given examples of analyses of data obtained from natural and social phenomena so that they can grasp practical definitions of statistical methods. Finally they go on to acquaint themselves with statistical software for the PC and analyze similar data to expand and deepen their understanding of statistical methods.

This book, however, takes a slightly different approach, using simulation data instead of actual data to illustrate the functions of statistical methods. Also, R programs listed in the book help readers realize clearly how these methods work to bring intrinsic values of data to the surface. R is free software enabling users to handle vectors, matrices, data frames, and so on.

For example, when a statistical theory indicates that an event happens with a 5 % probability, readers can confirm the fact using R programs that this event actually occurs with roughly that probability, by handling data generated by pseudo-random numbers. Simulation gives readers populations with known backgrounds and the nature of the population can be adjusted easily. This feature of the simulation data helps provide a clear picture of statistical methods painlessly.

Most readers of introductory books of statistics for practical purposes do not like complex mathematical formulae, but they do not mind using a PC to produce various numbers and graphs by handling a huge variety of numbers. If they know the characteristics of these numbers beforehand, they treat them with ease. Struggling with actual data should come later. Conventional books on this topic frighten readers by presenting unidentified data to them indiscriminately. This book provides a new path to statistical concepts and practical skills in a readily accessible manner. "

This focuses on the developing field of building probability models with the power of symbolic algebra systems. The book combines the uses of symbolic algebra with probabilistic/stochastic application and highlights the applications in a variety of contexts. The research explored in each chapter is unified by the use of A Probability Programming Language (APPL) to achieve the modeling objectives. APPL, as a research tool, enables a probabilist or statistician the ability to explore new ideas, methods, and models. Furthermore, as an open-source language, it sets the foundation for future algorithms to augment the original code. Computational Probability Applications is comprised of fifteen chapters, each presenting a specific application of computational probability using the APPL modeling and computer language. The chapter topics include using inverse gamma as a survival distribution, linear approximations of probability density functions, and also moment-ratio diagrams for univariate distributions. These works highlight interesting examples, often done by undergraduate students and graduate students that can serve as templates for future work. In addition, this book should appeal to researchers and practitioners in a range of fields including probability, statistics, engineering, finance, neuroscience, and economics.

During the last fifty years, Gopinath Kallianpur has made extensive and significant contributions to diverse areas of probability and statistics, including stochastic finance, Fisher consistent estimation, non-linear prediction and filtering problems, zero-one laws for Gaussian processes and reproducing kernel Hilbert space theory, and stochastic differential equations in infinite dimensions. To honor Kallianpur's pioneering work and scholarly achievements, a number of leading experts have written research articles highlighting progress and new directions of research in these and related areas. This commemorative volume, dedicated to Kallianpur on the occasion of his seventy-fifth birthday, will pay tribute to his multi-faceted achievements and to the deep insight and inspiration he has so graciously offered his students and colleagues throughout his career. Contributors to the volume: S. Aida, N. Asai, K. B. Athreya, R. N. Bhattacharya, A. Budhiraja, P. S. Chakraborty, P. Del Moral, R. Elliott, L. Gawarecki, D. Goswami, Y. Hu, J. Jacod, G. W. Johnson, L. Johnson, T. Koski, N. V. Krylov, I. Kubo, H.-H. Kuo, T. G. Kurtz, H. J. Kushner, V. Mandrekar, B. Margolius, R. Mikulevicius, I. Mitoma, H. Nagai, Y. Ogura, K. R. Parthasarathy, V. Perez-Abreu, E. Platen, B. V. Rao, B. Rozovskii, I. Shigekawa, K. B. Sinha, P. Sundar, M. Tomisaki, M. Tsuchiya, C. Tudor, W. A. Woycynski, J. Xiong

A comprehensive look at how probability and statistics is applied to the investment process

Finance has become increasingly more quantitative, drawing on techniques in probability and statistics that many finance practitioners have not had exposure to before. In order to keep up, you need a firm understanding of this discipline."Probability and Statistics for Finance" addresses this issue by showing you how to apply quantitative methods to portfolios, and in all matter of your practices, in a clear, concise manner. Informative and accessible, this guide starts off with the basics and builds to an intermediate level of mastery. - Outlines an array of topics in probability and statistics and how to apply them in the world of finance- Includes detailed discussions of descriptive statistics, basic probability theory, inductive statistics, and multivariate analysis- Offers real-world illustrations of the issues addressed throughout the textThe authors cover a wide range of topics in this book, which can be used by all finance professionals as well as students aspiring to enter the field of finance.

The papers contained in this volume are an indication of the topics th discussed and the interests of the participants of The 9 International Conference on Probability in Banach Spaces, held at Sandjberg, Denmark, August 16-21, 1993. A glance at the table of contents indicates the broad range of topics covered at this conference. What defines research in this field is not so much the topics considered but the generality of the ques tions that are asked. The goal is to examine the behavior of large classes of stochastic processes and to describe it in terms of a few simple prop erties that the processes share. The reward of research like this is that occasionally one can gain deep insight, even about familiar processes, by stripping away details, that in hindsight turn out to be extraneous. A good understanding about the disciplines involved in this field can be obtained from the recent book, Probability in Banach Spaces, Springer-Verlag, by M. Ledoux and M. Thlagrand. On page 5, of this book, there is a list of previous conferences in probability in Banach spaces, including the other eight international conferences. One can see that research in this field over the last twenty years has contributed significantly to knowledge in probability and has had important applications in many other branches of mathematics, most notably in statistics and functional analysis."

This volume provides an overview of the field of Astrostatistics understood as the sub-discipline dedicated to the statistical analysis of astronomical data. It presents examples of the application of the various methodologies now available to current open issues in astronomical research. The technical aspects related to the scientific analysis of the upcoming petabyte-scale databases are emphasized given the importance that scalable Knowledge Discovery techniques will have for the full exploitation of these databases. Based on the 2011 Astrostatistics and Data Mining in Large Astronomical Databases conference and school, this volume gathers examples of the work by leading authors in the areas of Astrophysics and Statistics, including a significant contribution from the various teams that prepared for the processing and analysis of the Gaia data.