Real-life problems are often quite complicated in form and nature and, for centuries, many different mathematical concepts, ideas and tools have been developed to formulate these problems theoretically and then to solve them either exactly or approximately.

This book aims to gather a collection of papers dealing with several different problems arising from many disciplines and some modern mathematical approaches to handle them. In this respect, the book offers a wide overview on many of the current trends in Mathematics as valuable formal techniques in capturing and exploiting the complexity involved in real-world situations.

Several researchers, colleagues, friends and students of Professor Maria Luisa Menendez have contributed to this volume to pay tribute to her and to recognize the diverse contributions she had made to the fields of Mathematics and Statistics and to the profession in general. She had a sweet and strong personality, and instilled great values and work ethics in her students through her dedication to teaching and research. Even though the academic community lost her prematurely, she would continue to provide inspiration to many students and researchers worldwide through her published work."

This book outlines Bayesian statistical analysis in great detail, from the development of a model through the process of making statistical inference. The key feature of this book is that it covers models that are most commonly used in social science research - including the linear regression model, generalized linear models, hierarchical models, and multivariate regression models - and it thoroughly develops each real-data example in painstaking detail.

This book covers the basic statistical and analytical techniques of computer intrusion detection. It is aimed at both statisticians looking to become involved in the data analysis aspects of computer security and computer scientists looking to expand their toolbox of techniques for detecting intruders. The book is self-contained, assumng no expertise in either computer security or statistics. It begins with a description of the basics of TCP/IP, followed by chapters dealing with network traffic analysis, network monitoring for intrusion detection, host based intrusion detection, and computer viruses and other malicious code. Each section develops the necessary tools as needed. There is an extensive discussion of visualization as it relates to network data and intrusion detection. The book also contains a large bibliography covering the statistical, machine learning, and pattern recognition literature related to network monitoring and intrusion detection. David Marchette is a scientist at the Naval Surface Warfacre Center in Dalhgren, Virginia. He has worked at Navy labs for 15 years, doing research in pattern recognition, computational statistics, and image analysis. He has been a fellow by courtesy in the mathematical sciences department of the Johns Hopkins University since 2000. He has been working in conputer intrusion detection for several years, focusing on statistical methods for anomaly detection and visualization. Dr. Marchette received a Masters in Mathematics from the University of California, San Diego in 1982 and a Ph.D. in Computational Sciences and Informatics from George Mason University in 1996.

This book contains selected contributions from the geoENV96 - First European Conference on Geostatistics for Environmental Applications, held in Lisbon in November 1996. This is the first of a geoENV series of biennial planned books. The series is intended to show the state of the art of geostatistics in environmental applications with new cases, results and relevant discussions from leading researchers and practitioners around the world. New and important theoretical and practical developments of geostatistics in the environmental field were compiled from three main areas: Hydrology, Groundwater and Groundwater Contamination Soil Contamination and Site Remediation Air Pollution, Ecology and Other Applications The book presents a set of geostatistical tools and approaches used to successfully resolve a variety of specific problems in environment modelling, especially those resulting from the typical scarcity of spatial sampling, the time component of very dynamic systems, the modelling of various systems of contaminants, the uncertainty assessment of health cost functions, etc. Prominent topics concerning methodological tools and methods, stochastic simulation techniques, models of integrating soft information (seismic and remote sensing images), inverse modelling of groundwater flow, neural network classification, change of support and up-scaling are also included in this book. This publication will be of great interest and practical value to geostatisticians working both in universities and in industry.

A function is convex if its epigraph is convex. This geometrical structure has very strong implications in terms of continuity and differentiability. Separation theorems lead to optimality conditions and duality for convex problems. A function is quasiconvex if its lower level sets are convex. Here again, the geo metrical structure of the level sets implies some continuity and differentiability properties for quasiconvex functions. Optimality conditions and duality can be derived for optimization problems involving such functions as well. Over a period of about fifty years, quasiconvex and other generalized convex functions have been considered in a variety of fields including economies, man agement science, engineering, probability and applied sciences in accordance with the need of particular applications. During the last twenty-five years, an increase of research activities in this field has been witnessed. More recently generalized monotonicity of maps has been studied. It relates to generalized convexity off unctions as monotonicity relates to convexity. Generalized monotonicity plays a role in variational inequality problems, complementarity problems and more generally, in equilibrium prob lems."

This book presents the latest advances in the theory and practice of Marshall-Olkin distributions. These distributions have been increasingly applied in statistical practice in recent years, as they make it possible to describe interesting features of stochastic models like non-exchangeability, tail dependencies and the presence of a singular component. The book presents cutting-edge contributions in this research area, with a particular emphasis on financial and economic applications. It is recommended for researchers working in applied probability and statistics, as well as for practitioners interested in the use of stochastic models in economics. This volume collects selected contributions from the conference "Marshall-Olkin Distributions: Advances in Theory and Applications," held in Bologna on October 2-3, 2013.

This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.

Multivariate polynomials are a main tool in approximation. The book begins with an introduction to the general theory by presenting the most important facts on multivariate interpolation, quadrature, orthogonal projections and their summation, all treated under a constructive view, and embedded in the theory of positive linear operators. On this background, the book gives the first comprehensive introduction to the recently developped theory of generalized hyperinterpolation. As an application, the book gives a quick introduction to tomography. Several parts of the book are based on rotation principles, which are presented in the beginning of the book, together with all other basic facts needed.

This book discusses dynamical systems that are typically driven by stochastic dynamic noise. It is written by two statisticians essentially for the statistically inclined readers, although readers whose primary interests are in determinate systems will find some of the methodology explained in this book of interest. The statistical approach adopted in this book differs in many ways from the deterministic approach to dynamical systems. Even the very basic notion of initial-value sensitivity requires careful development in the new setting provided. This book covers, in varying depth, many of the contributions made by the statisticians in the past twenty years or so towards our understanding of estimation, the Lyapunov-like index, the nonparametric regression, and many others, many of which are motivated by their dynamical system counterparts but have now acquired a distinct statistical flavour. Kung-Sik Chan is a professor at the University of Iowa, Department of Statistics and Actuarial Science. He is an elected member of the International Statistical Institute. He has served on the editorial boards of the Journal of Business and Economic Statistics and Statistica Sinica. He received a Faculty Scholar Award from the University of Iowa in 1996. Howell Tong holds the Chair of Statistics at the London School of Economics and the University of Hong Kong. He is a foreign member of the Norwegian Academy of Science and Letters, an elected member of the International Statistical Institute and a Council member of its Bernoulli Society, an elected fellow of the Institute of Mathematical Statistics, and an honorary fellow of the Institute of Actuaries (London). He was the Founding Dean of the Graduate School and sometimes the Acting Pro-Vice Chancellor (Research) at the University of Hong Kong. He has served on the editorial boards of several international journals, including Biometrika, Journal of Royal Statistical Society (Series B), Statistica Sinica, and others. He is a guest professor of the Academy of Mathematical and System Sciences of the Chinese Academy of Sciences and received a National Natural Science Prize (China) in the category of Mathematics and Mechanics (Class II) in 2001. He has also held visiting professorships at various universities, including the Imperial College in London, the ETH in Zurich, the Fourier University in Grenoble, the Wall Institute at the University of British Columbia, Vancouver, and the Chinese University of Hong Kong.

An increasing number of statistical problems and methods involve infinite-dimensional aspects. This is due to the progress of technologies which allow us to store more and more information while modern instruments are able to collect data much more effectively due to their increasingly sophisticated design. This evolution directly concerns statisticians, who have to propose new methodologies while taking into account such high-dimensional data (e.g. continuous processes, functional data, etc.). The numerous applications (micro-arrays, paleo- ecological data, radar waveforms, spectrometric curves, speech recognition, continuous time series, 3-D images, etc.) in various fields (biology, econometrics, environmetrics, the food industry, medical sciences, paper industry, etc.) make researching this statistical topic very worthwhile. This book gathers important contributions on the functional and operatorial statistics fields.

These three volumes comprise the proceedings of the US/Japan Conference, held in honour of Professor H. Akaike, on the Frontiers of Statistical Modeling: an Informational Approach'. The major theme of the conference was the implementation of statistical modeling through an informational approach to complex, real-world problems. Volume 1 contains papers which deal with the Theory and Methodology of Time Series Analysis. Volume 1 also contains the text of the Banquet talk by E. Parzen and the keynote lecture of H. Akaike. Volume 2 is devoted to the general topic of Multivariate Statistical Modeling, and Volume 3 contains the papers relating to Engineering and Scientific Applications. For all scientists whose work involves statistics.

This is the proceedings of the "8th IMACS Seminar on Monte Carlo Methods" held from August 29 to September 2, 2011 in Borovets, Bulgaria, and organized by the Institute of Information and Communication Technologies of the Bulgarian Academy of Sciences in cooperation with the International Association for Mathematics and Computers in Simulation (IMACS). Included are 24 papers which cover all topics presented in the sessions of the seminar: stochastic computation and complexity of high dimensional problems, sensitivity analysis, high-performance computations for Monte Carlo applications, stochastic metaheuristics for optimization problems, sequential Monte Carlo methods for large-scale problems, semiconductor devices and nanostructures. The history of the IMACS Seminar on Monte Carlo Methods goes back to April 1997 when the first MCM Seminar was organized in Brussels: 1st IMACS Seminar, 1997, Brussels, Belgium 2nd IMACS Seminar, 1999, Varna, Bulgaria 3rd IMACS Seminar, 2001, Salzburg, Austria 4th IMACS Seminar, 2003, Berlin, Germany 5th IMACS Seminar, 2005, Tallahassee, USA 6th IMACS Seminar, 2007, Reading, UK 7th IMACS Seminar, 2009, Brussels, Belgium 8th IMACS Seminar, 2011, Borovets, Bulgaria

The aim of this book is to report on the progress realized in probability theory in the field of dynamic random walks and to present applications in computer science, mathematical physics and finance. Each chapter contains didactical material as well as more advanced technical sections. Few appendices will help refreshing memories (if necessary!).
. New probabilistic model, new results in probability theory
. Original applications in computer science
. Applications in mathematical physics
. Applications in finance

This book disseminates the latest results and envisages new challenges in the application of mathematics to various practical situations in biology, epidemiology, and ecology. It comprises a collection of the main results presented at the Ninth Edition of the International Workshop "Dynamical Systems Applied to Biology and Natural Sciences - DSABNS", held from 7 to 9 February 2018 at the Department of Mathematics, University of Turin, Italy. While the principal focus is ecology and epidemiology, the coverage extends even to waste recycling and a genetic application. The topics covered in the 12 peer-reviewed contributions involve such diverse mathematical tools as ordinary and partial differential equations, delay equations, stochastic equations, control, and sensitivity analysis. The book is intended to help both in disseminating the latest results and in envisaging new challenges in the application of mathematics to various practical situations in biology, epidemiology, and ecology.

Spatial statistics are useful in subjects as diverse as climatology, ecology, economics, environmental and earth sciences, epidemiology, image analysis and more. This book covers the best-known spatial models for three types of spatial data: geostatistical data (stationarity, intrinsic models, variograms, spatial regression and space-time models), areal data (Gibbs-Markov fields and spatial auto-regression) and point pattern data (Poisson, Cox, Gibbs and Markov point processes). The level is relatively advanced, and the presentation concise but complete.

The most important statistical methods and their asymptotic properties are described, including estimation in geostatistics, autocorrelation and second-order statistics, maximum likelihood methods, approximate inference using the pseudo-likelihood or Monte-Carlo simulations, statistics for point processes and Bayesian hierarchical models. A chapter is devoted to Markov Chain Monte Carlo simulation (Gibbs sampler, Metropolis-Hastings algorithms and exact simulation).
A large number of real examples are studied with R, and each chapter ends with a set of theoretical and applied exercises. While a foundation in probability and mathematical statistics is assumed, three appendices introduce some necessary background. The book is accessible to senior undergraduate students with a solid math background and Ph.D. students in statistics. Furthermore, experienced statisticians and researchers in the above-mentioned fields will find the book valuable as a mathematically sound reference.

This book is the English translation of Modelisation et Statistique Spatiales published by Springer in the series Mathematiques & Applications, a series established by Societe de Mathematiques Appliquees et Industrielles (SMAI)."

Often a statistical analysis involves use of a set of alternative models for the data. A "model-selection criterion" is a formula which provides a figure-of merit for the alternative models. Generally the alternative models will involve different numhers of parameters. Model-selection criteria take into account hoth the goodness-or-fit of a model and the numher of parameters used to achieve that fit. 1.1. SETS OF ALTERNATIVE MODELS Thus the focus in this paper is on data-analytic situations ill which there is consideration of a set of alternative models. Choice of a suhset of explanatory variahles in regression, the degree of a polynomial regression, the number of factors in factor analysis, or the numher of dusters in duster analysis are examples of such situations. 1.2. MODEL SELECTION VERSUS HYPOTHESIS TESTING In exploratory data analysis or in a preliminary phase of inference an approach hased on model-selection criteria can offer advantages over tests of hypotheses. The model-selection approach avoids the prohlem of specifying error rates for the tests. With model selection the focus can he on simultaneous competition between a hroad dass of competing models rather than on consideration of a sequence of simpler and simpler models."

This book highlights the estimate of epidemic characteristics for different countries/regions in the world with the use of known SIR (susceptible-infected-removed) model for the dynamics of the epidemic, the known exact solution of the linear differential equations and statistical approach developed before. The COVID-19 pandemic is of great interest to researchers due to its high mortality and a negative impact to the world economy. Correct simulation of the pandemic dynamics needs complicated mathematical models and many efforts for unknown parameters identification. The simple method of detection of the new pandemic wave is proposed and SIR model generalized. The hidden periods, epidemic durations, final numbers of cases, the effective reproduction numbers and probabilities of meeting an infected person are presented for countries like USA, Germany, UK, the Republic of Korea, Italy, Spain, France, the Republic of Moldova, Ukraine, and for the world. The presented information is useful to regulate the quarantine activities and to predict the medical and economic consequences of different/future pandemics.

Gian-Carlo Rota was born in Vigevano, Italy, in 1932. He died in Cambridge, Mas sachusetts, in 1999. He had several careers, most notably as a mathematician, but also as a philosopher and a consultant to the United States government. His mathe matical career was equally varied. His early mathematical studies were at Princeton (1950 to 1953) and Yale (1953 to 1956). In 1956, he completed his doctoral thesis under the direction of Jacob T. Schwartz. This thesis was published as the pa per "Extension theory of differential operators I", the first paper reprinted in this volume. Rota's early work was in analysis, more specifically, in operator theory, differ ential equations, ergodic theory, and probability theory. In the 1960's, Rota was motivated by problems in fluctuation theory to study some operator identities of Glen Baxter (see [7]). Together with other problems in probability theory, this led Rota to study combinatorics. His series of papers, "On the foundations of combi natorial theory", led to a fundamental re-evaluation of the subject. Later, in the 1990's, Rota returned to some of the problems in analysis and probability theory which motivated his work in combinatorics. This was his intention all along, and his early death robbed mathematics of his unique perspective on linkages between the discrete and the continuous. Glimpses of his new research programs can be found in [2,3,6,9,10].

As a result of the COVID-19 pandemic, medical statistics and public health data have become staples of newsfeeds worldwide, with infection rates, deaths, case fatality and the mysterious R figure featuring regularly. However, we don't all have the statistical background needed to translate this information into knowledge. In this lively account, Stephen Senn explains these statistical phenomena and demonstrates how statistics is essential to making rational decisions about medical care. The second edition has been thoroughly updated to cover developments of the last two decades and includes a new chapter on medical statistical challenges of COVID-19, along with additional material on infectious disease modelling and representation of women in clinical trials. Senn entertains with anecdotes, puzzles and paradoxes, while tackling big themes including: clinical trials and the development of medicines, life tables, vaccines and their risks or lack of them, smoking and lung cancer, and even the power of prayer.

This book gives a comprehensive treatment of random phenomena and distribution results in diophantine approximation, with a particular emphasis on quadratic irrationals. It covers classical material on the subject as well as many new results developed by the author over the past decade. A range of ideas from other areas of mathematics are brought to bear with surprising connections to topics such as formulae for class numbers, special values of L-functions, and Dedekind sums. Care is taken to elaborate difficult proofs by motivating major steps and accompanying them with background explanations, enabling the reader to learn the theory and relevant techniques. Written by one of the acknowledged experts in the field, Probabilistic Diophantine Approximation is presented in a clear and informal style with sufficient detail to appeal to both advanced students and researchers in number theory.

This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.

Hidden Markov models have become a widely used class of statistical models with applications in diverse areas such as communications engineering, bioinformatics, finance and many more. This book is a comprehensive treatment of inference for hidden Markov models, including both algorithms and statistical theory. Topics range from filtering and smoothing of the hidden Markov chain to parameter estimation, Bayesian methods and estimation of the number of states. In a unified way the book covers both models with finite state spaces, which allow for exact algorithms for filtering, estimation etc. and models with continuous state spaces (also called state-space models) requiring approximate simulation-based algorithms that are also described in detail. Simulation in hidden Markov models is addressed in five different chapters that cover both Markov chain Monte Carlo and sequential Monte Carlo approaches. Many examples illustrate the algorithms and theory. The book also carefully treats Gaussian linear state-space models and their extensions and it contains a chapter on general Markov chain theory and probabilistic aspects of hidden Markov models. This volume will suit anybody with an int background, while the more theoretical parts require knowledge of probability theory at the measure-theoretical level.

This research monograph utilizes exact and Monte Carlo permutation statistical methods to generate probability values and measures of effect size for a variety of measures of association. Association is broadly defined to include measures of correlation for two interval-level variables, measures of association for two nominal-level variables or two ordinal-level variables, and measures of agreement for two nominal-level or two ordinal-level variables. Additionally, measures of association for mixtures of the three levels of measurement are considered: nominal-ordinal, nominal-interval, and ordinal-interval measures. Numerous comparisons of permutation and classical statistical methods are presented. Unlike classical statistical methods, permutation statistical methods do not rely on theoretical distributions, avoid the usual assumptions of normality and homogeneity of variance, and depend only on the data at hand. This book takes a unique approach to explaining statistics by integrating a large variety of statistical methods, and establishing the rigor of a topic that to many may seem to be a nascent field. This topic is relatively new in that it took modern computing power to make permutation methods available to those working in mainstream research. Written for a statistically informed audience, it is particularly useful for teachers of statistics, practicing statisticians, applied statisticians, and quantitative graduate students in fields such as psychology, medical research, epidemiology, public health, and biology. It can also serve as a textbook in graduate courses in subjects like statistics, psychology, and biology.

These three volumes comprise the proceedings of the US/Japan Conference, held in honour of Professor H. Akaike, on the Frontiers of Statistical Modeling: an Informational Approach'. The major theme of the conference was the implementation of statistical modeling through an informational approach to complex, real-world problems. Volume 1 contains papers which deal with the Theory and Methodology of Time Series Analysis. Volume 1 also contains the text of the Banquet talk by E. Parzen and the keynote lecture of H. Akaike. Volume 2 is devoted to the general topic of Multivariate Statistical Modeling, and Volume 3 contains the papers relating to Engineering and Scientific Applications. For all scientists whose work involves statistics.

The book addresses the problem of calculation of d-dimensional integrals (conditional expectations) in filter problems. It develops new methods of deterministic numerical integration, which can be used to speed up and stabilize filter algorithms. With the help of these methods, better estimates and predictions of latent variables are made possible in the fields of economics, engineering and physics. The resulting procedures are tested within four detailed simulation studies.