Now in its third edition and supplemented with more online material, this book aims to make the "new" information-based (rather than gene-based) bioinformatics intelligible both to the "bio" people and the "info" people. Books on bioinformatics have traditionally served gene-hunters, and biologists who wish to construct family trees showing tidy lines of descent. While dealing extensively with the exciting topics of gene discovery and database-searching, such books have hardly considered genomes as information channels through which multiple forms and levels of information have passed through the generations. This "new bioinformatics" contrasts with the "old" gene-based bioinformatics that so preoccupies previous texts. Forms of information that we are familiar with (mental, textual) are related to forms with which we are less familiar (hereditary). The book extends a line of evolutionary thought that leads from the nineteenth century (Darwin, Butler, Romanes, Bateson), through the twentieth (Goldschmidt, White), and into the twenty first (the final works of the late Stephen Jay Gould). Long an area of controversy, diverging views may now be reconciled.

The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: * Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs * Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications * Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points * Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model * A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.

This book covers the method of metric distances and its application in probability theory and other fields. The method is fundamental in the study of limit theorems and generally in assessing the quality of approximations to a given probabilistic model. The method of metric distances is developed to study stability problems and reduces to the selection of an ideal or the most appropriate metric for the problem under consideration and a comparison of probability metrics. After describing the basic structure of probability metrics and providing an analysis of the topologies in the space of probability measures generated by different types of probability metrics, the authors study stability problems by providing a characterization of the ideal metrics for a given problem and investigating the main relationships between different types of probability metrics. The presentation is provided in a general form, although specific cases are considered as they arise in the process of finding supplementary bounds or in applications to important special cases. Svetlozar T. Rachev is the Frey Family Foundation Chair of Quantitative Finance, Department of Applied Mathematics and Statistics, SUNY-Stony Brook and Chief Scientist of Finanlytica, USA. Lev B. Klebanov is a Professor in the Department of Probability and Mathematical Statistics, Charles University, Prague, Czech Republic. Stoyan V. Stoyanov is a Professor at EDHEC Business School and Head of Research, EDHEC-Risk Institute-Asia (Singapore). Frank J. Fabozzi is a Professor at EDHEC Business School. (USA)

Limit theorems and asymptotic results form a central topic in probability theory and mathematical statistics. New and non-classical limit theorems have been discovered for processes in random environments, especially in connection with random matrix theory and free probability. These questions and the techniques for answering them combine asymptotic enumerative combinatorics, particle systems and approximation theory, and are important for new approaches in geometric and metric number theory as well. Thus, the contributions in this book include a wide range of applications with surprising connections ranging from longest common subsequences for words, permutation groups, random matrices and free probability to entropy problems and metric number theory.

The book is the product of a conference that took place in August 2011 in Bielefeld, Germany to celebrate the 60th birthday of Friedrich Gotze, a noted expert in this field."

Study smarter and stay on top of your probability course with the bestselling Schaum's Outline-now with the NEW Schaum's app and website! Schaum's Outline of Probability, Third Edition is the go-to study guide for help in probability courses. It's ideal for undergrads, graduate students and professionals needing a tool for review. With an outline format that facilitates quick and easy review and mirrors the course in scope and sequence, this book helps you understand basic concepts and get the extra practice you need to excel in the course. Schaum's Outline of Probability, Third Edition supports the bestselling textbooks and is useful for a variety of classes, including Elementary Probability and Statistics, Data Analysis, Finite Mathematics, and many other courses. You'll find coverage on finite and countable sets, binomial coefficients, axioms of probability, conditional probability, expectation of a finite random variable, Poisson distribution, and probability of vectors and Stochastic matrices. Also included: finite Stochastic and tree diagrams, Chebyshev's inequality and the law of large numbers, calculations of binomial probabilities using normal approximation, and regular Markov processes and stationary state distributions. Features *NEW to this edition: the new Schaum's app and website! *NEW to this edition: 20 NEW problem-solving videos online *430 solved problems *Outline format to provide a concise guide to the standard college course in probability *Clear, concise explanations of probability concepts *Supports these major texts: Elementary Statistics: A Step by Step Approach (Bluman), Mathematics with Applications (Hungerford), and Discrete Mathematics and Its Applications (Rosen) *Appropriate for the following courses: Elementary Probability and Statistics, Data Analysis, Finite Mathematics, Introduction to Mathematical Statistics, Mathematics for Biological Sciences, Introductory Statistics, Discrete Mathematics, Probability for Applied Science, and Introduction to Probability Theory

Analyzing observed or measured data is an important step in applied sciences. The recent increase in computer capacity has resulted in a revolution both in data collection and data analysis. An increasing number of scientists, researchers and students are venturing into statistical data analysis; hence the need for more guidance in this field, which was previously dominated mainly by statisticians.

This handbook fills the gap in the range of textbooks on data analysis. Written in a dictionary format, it will serve as a comprehensive reference book in a rapidly growing field. However, this book is more structured than an ordinary dictionary, where each entry is a separate, self-contained entity. The authors provide not only definitions and short descriptions, but also offer an overview of the different topics. Therefore, the handbook can also be used as a companion to textbooks for undergraduate or graduate courses.

1700 entries are given in alphabetical order grouped into 20 topics and each topic is organized in a hierarchical fashion. Additional specific entries on a topic can be easily found by following the cross-references in a top-down manner. Several figures and tables are provided to enhance the comprehension of the topics and a list of acronyms helps to locate the full terminologies. The bibliography offers suggestions for further reading.

This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second expanded edition adds new material published during the last decade, with nearly 200 new references. More material has been added on infinitely-dimensional multitype processes, including the infinitely-dimensional linear-fractional case. Hypergeometric function treatment of the special case of the Griffiths-Pakes infinite allele branching process has also been added. There are additional applications of recent molecular processes and connections with systems biology are explored, and a new chapter on genealogies of branching processes and their applications. Reviews of First Edition: "This is a significant book on applications of branching processes in biology, and it is highly recommended for those readers who are interested in the application and development of stochastic models, particularly those with interests in cellular and molecular biology." (Siam Review, Vol. 45 (2), 2003) "This book will be very interesting and useful for mathematicians, statisticians and biologists as well, and especially for researchers developing mathematical methods in biology, medicine and other natural sciences." (Short Book Reviews of the ISI, Vol. 23 (2), 2003)

Nonparametric function estimation with stochastic data, otherwise known as smoothing, has been studied by several generations of statisticians. Assisted by the ample computing power in today's servers, desktops, and laptops, smoothing methods have been finding their ways into everyday data analysis by practitioners. While scores of methods have proved successful for univariate smoothing, ones practical in multivariate settings number far less. Smoothing spline ANOVA models are a versatile family of smoothing methods derived through roughness penalties, that are suitable for both univariate and multivariate problems. In this book, the author presents a treatise on penalty smoothing under a unified framework. Methods are developed for (i) regression with Gaussian and non-Gaussian responses as well as with censored lifetime data; (ii) density and conditional density estimation under a variety of sampling schemes; and (iii) hazard rate estimation with censored life time data and covariates. The unifying themes are the general penalized likelihood method and the construction of multivariate models with built-in ANOVA decompositions. Extensive discussions are devoted to model construction, smoothing parameter selection, computation, and asymptotic convergence. Most of the computational and data analytical tools discussed in the book are implemented in R, an open-source platform for statistical computing and graphics. Suites of functions are embodied in the R package gss, and are illustrated throughout the book using simulated and real data examples. This monograph will be useful as a reference work for researchers in theoretical and applied statistics as well as for those in other related disciplines. It can also be used as a text for graduate level courses on the subject. Most of the materials are accessible to a second year graduate student with a good training in calculus and linear algebra and working knowledge in basic statistical inferences such as linear models and maximum likelihood estimates.

This book deals with the application of wavelet and spectral methods for the analysis of nonlinear and dynamic processes in economics and finance. It reflects some of the latest developments in the area of wavelet methods applied to economics and finance. The topics include business cycle analysis, asset prices, financial econometrics, and forecasting. An introductory paper by James Ramsey, providing a personal retrospective of a decade's research on wavelet analysis, offers an excellent overview over the field.

This book brings together important topics of current research in probabilistic graphical modeling, learning from data and probabilistic inference. Coverage includes such topics as the characterization of conditional independence, the learning of graphical models with latent variables, and extensions to the influence diagram formalism as well as important application fields, such as the control of vehicles, bioinformatics and medicine.

This book presents some recent developments in correlated data analysis. It utilizes the class of dispersion models as marginal components in the formulation of joint models for correlated data. This enables the book to handle a broader range of data types than those analyzed by traditional generalized linear models. One example is correlated angular data. This book provides a systematic treatment for the topic of estimating functions. Under this framework, both generalized estimating equations (GEE) and quadratic inference functions (QIF) are studied as special cases. In addition to marginal models and mixed-effects models, this book covers topics on joint regression analysis based on Gaussian copulas and generalized state space models for longitudinal data from long time series. Various real-world data examples, numerical illustrations and software usage tips are presented throughout the book. This book has evolved from lecture notes on longitudinal data analysis, and may be considered suitable as a textbook for a graduate course on correlated data analysis. This book is inclined more towards technical details regarding the underlying theory and methodology used in software-based applications. Therefore, the book will serve as a useful reference for those who want theoretical explanations to puzzles arising from data analyses or deeper understanding of underlying theory related to analyses.

This Handbook covers latent variable models, which are a flexible class of models for modeling multivariate data to explore relationships among observed and latent variables.
- Covers a wide class of important models
- Models and statistical methods described provide tools for analyzing a wide spectrum of complicated data
- Includes illustrative examples with real data sets from business, education, medicine, public health and sociology.
- Demonstrates the use of a wide variety of statistical, computational, and mathematical techniques.

This book is dedicated to Prof. Peter Young on his 70th birthday. Professor Young has been a pioneer in systems and control, and over the past 45 years he has influenced many developments in this field. This volume comprises a collection of contributions by leading experts in system identification, time-series analysis, environmetric modelling and control system design - modern research in topics that reflect important areas of interest in Professor Young's research career. Recent theoretical developments in and relevant applications of these areas are explored treating the various subjects broadly and in depth. The authoritative and up-to-date research presented here will be of interest to academic researcher in control and disciplines related to environmental research, particularly those to with water systems. The tutorial style in which many of the contributions are composed also makes the book suitable as a source of study material for graduate students in those areas.

Universal codes efficiently compress sequences generated by stationary and ergodic sources with unknown statistics, and they were originally designed for lossless data compression. In the meantime, it was realized that they can be used for solving important problems of prediction and statistical analysis of time series, and this book describes recent results in this area. The first chapter introduces and describes the application of universal codes to prediction and the statistical analysis of time series; the second chapter describes applications of selected statistical methods to cryptography, including attacks on block ciphers; and the third chapter describes a homogeneity test used to determine authorship of literary texts. The book will be useful for researchers and advanced students in information theory, mathematical statistics, time-series analysis, and cryptography. It is assumed that the reader has some grounding in statistics and in information theory.

This volume presents a concise and practical overview of statistical methods and tables not readily available in other publications. It begins with a review of the commonly used continuous and discrete probability distributions. Several useful distributions that are not so common and less understood are described with examples and applications in full detail: discrete normal, left-partial, right-partial, left-truncated normal, right-truncated normal, lognormal, bivariate normal, and bivariate lognormal. Table values are provided with examples that enable researchers to easily apply the distributions to real applications and sample data. The left- and right-truncated normal distributions offer a wide variety of shapes in contrast to the symmetrically shaped normal distribution, and a newly developed spread ratio enables analysts to determine which of the three distributions best fits a particular set of sample data. The book will be highly useful to anyone who does statistical and probability analysis. This includes scientists, economists, management scientists, market researchers, engineers, mathematicians, and students in many disciplines.

This volume collects a selection of refereed papers of the more than one hundred presented at the InternationalConference MAF 2008 - Mathematicaland Statistical Methods for Actuarial Sciences and Finance. The conference was organised by the Department of Applied Mathematics and theDepartment ofStatisticsoftheUniversityCa'Foscari Venice(Italy), withthec- laborationofthe Department ofEconomics and StatisticalSciences ofthe University ofSalerno(Italy).Itwas heldinVenice, fromMarch 26to28,2008, attheprestigious CavalliFranchettipalace, alongGrand Canal, oftheIstitutoVenetodiScienze, Lettere ed Arti. This conference was the ?rst international edition of a biennial national series begunin2004, whichwas bornof thebrilliantbeliefofthe colleagues -and friends- oftheDepartmentofEconomicsandStatisticalSciences oftheUniversityofSalerno: the idea following which the cooperation between mathematicians and statisticians in working in actuarial sciences, in insurance and in ?nance can improve research on these topics. The proof of this consists in the wide participation in these events. In particular, with reference to the 2008 internationaledition: - More than 150 attendants, both academicians and practitioners; - More than 100 accepted communications, organised in 26 parallel sessions, from authors coming from about twenty countries (namely: Canada, Colombia, Czech Republic, France, Germany, Great Britain, Greece, Hungary, Ireland, Israel, Italy, Japan, Poland, Spain, Sweden, Switzerland, Taiwan, USA); - two plenary guest-organised sessions; and - aprestigiouskeynotelecturedeliveredbyProfessorWolfgangHa ]rdleoftheH- boldt Universityof Berlin (Germany)

This monograph focuses on the construction of regression models with linear and non-linear constrain inequalities from the theoretical point of view. Unlike previous publications, this volume analyses the properties of regression with inequality constrains, investigating the flexibility of inequality constrains and their ability to adapt in the presence of additional a priori information The implementation of inequality constrains improves the accuracy of models, and decreases the likelihood of errors. Based on the obtained theoretical results, a computational technique for estimation and prognostication problems is suggested. This approach lends itself to numerous applications in various practical problems, several of which are discussed in detail The book is useful resource for graduate students, PhD students, as well as for researchers who specialize in applied statistics and optimization. This book may also be useful to specialists in other branches of applied mathematics, technology, econometrics and finance

Geostatistics is a common tool in reservoir characterization. Written from the basics of statistics, this book covers only those topics that are needed for the two goals of the text: to exhibit the diagnostic potential of statistics and to introduce the important features of statistical modelling. This revised edition contains expanded discussions of some materials, in particular conditional probabilities, Bayes Theorem, correlation, and Kriging. The coverage of estimation, variability, and modelling applications have been updated. Seventy examples illustrate concepts and show the role of geology for providing important information for data analysis and model building. Four reservoir case studies conclude the presentation, illustrating the application and importance of the earlier material. This book aims to help petroleum professionals develop more accurate models, leading to lower sampling costs. It is an ideal book for petroleum engineers, geoscientists, hydrologists, and faculty and students in these and related fields.

This book lays the foundations for a theory on almost periodic stochastic processes and their applications to various stochastic differential equations, functional differential equations with delay, partial differential equations, and difference equations. It is in part a sequel of authors recent work on almost periodic stochastic difference and differential equations and has the particularity to be the first book that is entirely devoted to almost periodic random processes and their applications. The topics treated in it range from existence, uniqueness, and stability of solutions for abstract stochastic difference and differential equations.

About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. In this book, the statistical aspects of both the design and analysis of trials are described, with particular emphasis on recently developed methods of analysis.

This volume contains a collection of papers dedicated to Professor Eckhard Platen to celebrate his 60th birthday, which occurred in 2009. The contributions have been written by a number of his colleagues and co-authors. All papers have been - viewed and presented as keynote talks at the international conference "Quantitative Methods in Finance" (QMF) in Sydney in December 2009. The QMF Conference Series was initiated by Eckhard Platen in 1993 when he was at the Australian - tional University (ANU) in Canberra. Since joining UTS in 1997 the conference came to be organised on a much larger scale and has grown to become a signi?cant international event in quantitative ?nance. Professor Platen has held the Chair of Quantitative Finance at the University of Technology, Sydney (UTS) jointly in the Faculties of Business and Science since 1997. Prior to this appointment, he was the Founding Head of the Centre for Fin- cial Mathematics at the Institute of Advanced Studies at ANU, a position to which he was appointed in 1994. Eckhard completed a PhD in Mathematics at the Technical University in Dresden in 1975 and in 1985 obtained his Doctor of Science degree (Habilitation degree in the German system) from the Academy of Sciences in Berlin where he headed the Stochastics group at the Weierstrass Institute.

In April 2007, the Deutsche Forschungsgemeinschaft (DFG) approved the Priority Program 1324 "Mathematical Methods for Extracting Quantifiable Information from Complex Systems." This volume presents a comprehensive overview of the most important results obtained over the course of the program. Mathematical models of complex systems provide the foundation for further technological developments in science, engineering and computational finance. Motivated by the trend toward steadily increasing computer power, ever more realistic models have been developed in recent years. These models have also become increasingly complex, and their numerical treatment poses serious challenges. Recent developments in mathematics suggest that, in the long run, much more powerful numerical solution strategies could be derived if the interconnections between the different fields of research were systematically exploited at a conceptual level. Accordingly, a deeper understanding of the mathematical foundations as well as the development of new and efficient numerical algorithms were among the main goals of this Priority Program. The treatment of high-dimensional systems is clearly one of the most challenging tasks in applied mathematics today. Since the problem of high-dimensionality appears in many fields of application, the above-mentioned synergy and cross-fertilization effects were expected to make a great impact. To be truly successful, the following issues had to be kept in mind: theoretical research and practical applications had to be developed hand in hand; moreover, it has proven necessary to combine different fields of mathematics, such as numerical analysis and computational stochastics. To keep the whole program sufficiently focused, we concentrated on specific but related fields of application that share common characteristics and as such, they allowed us to use closely related approaches.

The fourth edition of this successful textbook presents a comprehensive introduction to statistical and numerical methods for the evaluation of empirical and experimental data. Equal weight is given to statistical theory and practical problems. The concise mathematical treatment of the subject matter is illustrated by many examples and for the present edition a library of Java programs has been developed. It comprises methods of numerical data analysis and graphical representation as well as many example programs and solutions to programming problems. The programs (source code, Java classes and documentation) and extensive appendices to the main text are available for free download from the book's page at www.springer.com.

ContentsProbabilities. Random variables.Random numbers and the Monte Carlo Method.Statistical distributions (binomial, Gauss, Poisson). Samples. Statistical tests.Maximum Likelihood. Least Squares. Regression. Minimization.Analysis of Variance. Time series analysis.

Audience

The book is conceived both as an introduction and as a work of reference. In particular it addresses itself to students, scientists and practitioners in science and engineering as a help in the analysis of their datain laboratory courses, in working for bachelor or master degrees, in thesis work, in research and professional work.

""The book is concise, but gives a sufficiently rigorous mathematical treatment of practical statistical methods for data analysis; it can be of great use to all who are involved with data analysis." "Physicalia""

.".".Serves as a nice reference guide for any scientist interested in the fundamentals of data analysis on the computer." "The American Statistician

""This lively and erudite treatise covers the theory of the main statistical tools and their practical applications...a first rate university textbook, and good background material for the practicing physicist." "Physics Bulletin

The Author

Siegmund Brandt is Emeritus Professor of Physics at the University of Siegen. With his group he worked on experiments in elementary-particle physics at the research centers DESY in Hamburg and CERN in Geneva in which the analysis of the experimental data plays an important role. He is author or coauthor of textbooks which have appeared in ten languages.

This book presents basic aspects for a theory of statistics with fuzzy data, together with a set of practical applications. Theories of fuzzy logic and of random closed sets are used as basic ingredients in building statistical concepts and procedures in the context of imprecise data, including coarse data analysis. The book aims at motivating statisticians to examine fuzzy statistics to enlarge the domain of applicability of statistics in general.