Key Features: Provides the taxonomy of the concepts and a navigation tool for the field of DTx. Covers important strategic aspects of the DTx industry, thereby helping investors, developers, and regulators gain a better appreciation of the potential value of DTx. Expounds on many existing and emerging state-of-the art scientific and technological tools, as well as data privacy, ethical and regulatory considerations for DTx product development. Presents several case studies of successful development of some of the most remarkable DTx products. Provides some perspectives and forward-looking statements on the future of digital medicine.

First Published in 1967. Routledge is an imprint of Taylor & Francis, an informa company.

Alan C. Acock's A Gentle Introduction to Stata, Revised Sixth Edition is aimed at new Stata users who want to become proficient in Stata. After reading this introductory text, new users will be able to not only use Stata well but also learn new aspects of Stata. Acock assumes that the user is not familiar with any statistical software. This assumption of a blank slate is central to the structure and contents of the book. Acock starts with the basics; for example, the part of the book that deals with data management begins with a careful and detailed example of turning survey data on paper into a Stata-ready dataset. When explaining how to go about basic exploratory statistical procedures, Acock includes notes that will help the reader develop good work habits. This mixture of explaining good Stata habits and explaining good statistical habits continues throughout the book. Acock is quite careful to teach the reader all aspects of using Stata. He covers data management, good work habits (including the use of basic do-files), basic exploratory statistics (including graphical displays), and analyses using the standard array of basic statistical tools (correlation, linear and logistic regression, and parametric and nonparametric tests of location and dispersion). He also successfully introduces some more advanced topics such as multiple imputation and multilevel modeling in a very approachable manner. Acock teaches Stata commands by using the menus and dialog boxes while still stressing the value of Stata commands and do-files. In this way, he ensures that all types of users can build good work habits. Each chapter has exercises that the motivated reader can use to reinforce the material. The tone of the book is friendly and conversational without ever being glib or condescending. Important asides and notes about terminology are set off in boxes, which makes the text easy to read without any convoluted twists or forward referencing. Rather than splitting topics by their Stata implementation, Acock arranges the topics as they would appear in a basic statistics textbook; graphics and postestimation are woven into the material naturally. Real datasets, such as the General Social Surveys from 2002, 2006, and 2016, are used throughout the book. The focus of the book is especially helpful for those in the behavioral and social sciences because the presentation of basic statistical modeling is supplemented with discussions of effect sizes and standardized coefficients. Various selection criteria, such as semipartial correlations, are discussed for model selection. Acock also covers a variety of commands available for evaluating reliability and validity of measurements. The revised sixth edition is fully up to date for Stata 17, including updated discussion and images of Stata's interface and modern command syntax. In addition, examples include new features such as the table command and collect suite for creating and exporting customized tables as well as the option for creating graphs with transparency.

Designed for students training to become biostatisticians as well as practicing biostatisticians, Inference Principles for Biostatisticians presents the theoretical and conceptual foundations of biostatistics. It covers the theoretical underpinnings essential to understanding subsequent core methodologies in the field. Drawing on his extensive experience teaching graduate-level biostatistics courses and working in the pharmaceutical industry, the author explains the main principles of statistical inference with many examples and exercises. Extended examples illustrate key concepts in depth using a specific biostatistical context. In addition, the author uses simulation to reinforce the repeated sampling interpretation of numerous statistical concepts. Reducing the computational complexities, he provides simple R functions for conducting simulation studies. This text gives graduate students with diverse backgrounds across the health, medical, social, and mathematical sciences a solid, unified foundation in the principles of statistical inference. This groundwork will lead students to develop a thorough understanding of biostatistical methodology.

With the internationalization of Renminbi (RMB), the gradual liberalization of China's capital account and the recent reform of the RMB pricing mechanism, the RMB exchange rate has been volatile. This book examines how we can forecast exchange rate reliably. It explains how we can do so through a new methodology for exchange rate forecasting. The book also analyzes the dynamic relationship between exchange rate and the exchange rate data decomposition and integration, the domestic economic situation, the international economic situation and the public's expectations and how these interactions would affect the exchange rate. The book also explains why this comprehensive integrated approach is the best model for optimizing accuracy in exchange rate forecasting.

First book on the subject, illustrative examples, some original results, self-contained material, a reference book.

INSTANT NEW YORK TIMES BESTSELLER "A new masterpiece from one of my favorite authors... [How The World Really Works] is a compelling and highly readable book that leaves readers with the fundamental grounding needed to help solve the world's toughest challenges."-Bill Gates "Provocative but perceptive . . . You can agree or disagree with Smil-accept or doubt his 'just the facts' posture-but you probably shouldn't ignore him."-The Washington Post An essential analysis of the modern science and technology that makes our twenty-first century lives possible-a scientist's investigation into what science really does, and does not, accomplish. We have never had so much information at our fingertips and yet most of us don't know how the world really works. This book explains seven of the most fundamental realities governing our survival and prosperity. From energy and food production, through our material world and its globalization, to risks, our environment and its future, How the World Really Works offers a much-needed reality check-because before we can tackle problems effectively, we must understand the facts. In this ambitious and thought-provoking book we see, for example, that globalization isn't inevitable-the foolishness of allowing 70 per cent of the world's rubber gloves to be made in just one factory became glaringly obvious in 2020-and that our societies have been steadily increasing their dependence on fossil fuels, such that any promises of decarbonization by 2050 are a fairy tale. For example, each greenhouse-grown supermarket-bought tomato has the equivalent of five tablespoons of diesel embedded in its production, and we have no way of producing steel, cement or plastics at required scales without huge carbon emissions. Ultimately, Smil answers the most profound question of our age: are we irrevocably doomed or is a brighter utopia ahead? Compelling, data-rich and revisionist, this wonderfully broad, interdisciplinary guide finds faults with both extremes. Looking at the world through this quantitative lens reveals hidden truths that change the way we see our past, present and uncertain future.

"A First Course in Machine Learning by Simon Rogers and Mark Girolami is the best introductory book for ML currently available. It combines rigor and precision with accessibility, starts from a detailed explanation of the basic foundations of Bayesian analysis in the simplest of settings, and goes all the way to the frontiers of the subject such as infinite mixture models, GPs, and MCMC." -Devdatt Dubhashi, Professor, Department of Computer Science and Engineering, Chalmers University, Sweden "This textbook manages to be easier to read than other comparable books in the subject while retaining all the rigorous treatment needed. The new chapters put it at the forefront of the field by covering topics that have become mainstream in machine learning over the last decade." -Daniel Barbara, George Mason University, Fairfax, Virginia, USA "The new edition of A First Course in Machine Learning by Rogers and Girolami is an excellent introduction to the use of statistical methods in machine learning. The book introduces concepts such as mathematical modeling, inference, and prediction, providing 'just in time' the essential background on linear algebra, calculus, and probability theory that the reader needs to understand these concepts." -Daniel Ortiz-Arroyo, Associate Professor, Aalborg University Esbjerg, Denmark "I was impressed by how closely the material aligns with the needs of an introductory course on machine learning, which is its greatest strength...Overall, this is a pragmatic and helpful book, which is well-aligned to the needs of an introductory course and one that I will be looking at for my own students in coming months." -David Clifton, University of Oxford, UK "The first edition of this book was already an excellent introductory text on machine learning for an advanced undergraduate or taught masters level course, or indeed for anybody who wants to learn about an interesting and important field of computer science. The additional chapters of advanced material on Gaussian process, MCMC and mixture modeling provide an ideal basis for practical projects, without disturbing the very clear and readable exposition of the basics contained in the first part of the book." -Gavin Cawley, Senior Lecturer, School of Computing Sciences, University of East Anglia, UK "This book could be used for junior/senior undergraduate students or first-year graduate students, as well as individuals who want to explore the field of machine learning...The book introduces not only the concepts but the underlying ideas on algorithm implementation from a critical thinking perspective." -Guangzhi Qu, Oakland University, Rochester, Michigan, USA

This book developed from a course given by the author to undergraduate and postgraduate students. It takes up Matrix Theory, Antenna Theory, and Probability Theory in detail. The first chapter on matrix theory discusses in reasonable depth the theory of Lie Algebras leading upto Cartan's Classification Theory. It also discusses some basic elements of Functional Analysis and Operator Theory in infinite dimensional Banach and Hilbert spaces. The second chapter discusses Basic Probability Theory and the topics discussed find applications to Stochastic Filtering Theory for differential equations driven by white Gaussian noise. The third chapter is on Antenna Theory with a focus on Modern Quantum Antenna Theory. The book will be a valuable resource to students and early career researchers in the field of Mathametical Physics.

-Includes simplified statistical contents and step by step guide on how to apply the statistical concepts by perform analysis using SPSS together with interpretation of the statistical analysis output. -Provides a wide range of data sets to be used for examples and illustrations. -Designed to be accessible to readers with varied backgrounds.

Operation Research methods are often used in every field of modern life like industry, economy and medicine. The authors have compiled of the latest advancements in these methods in this volume comprising some of what is considered the best collection of these new approaches. These can be counted as a direct shortcut to what you may search for. This book provides useful applications of the new developments in OR written by leading scientists from some international universities. Another volume about exciting applications of Operations Research is planned in the near future. We hope you enjoy and benefit from this series!

Guides the reader into the mysteries of water. Provides a state-of-the-art overview in computer simulations and experiments on water. Brings together leading scientists in the field of water.

Helps readers to transition from traditional statistics to modern data science Reviews the pros and cons of open source and commercial software packages, and their proper applications in specific situations. Explores data using dynamic methods rather than counting on dichotomous thinking. Considers alternate models using ensemble models and model comparison rather than fixing a preconceived hypothesis/model on a single method. Shows how to find the hidden pattern in the data by dynamic visualization rather than over-relying on numeric results.

This book is aimed directly at students of geography, particularly those who lack confidence in manipulating numbers. The aim is not to teach the mathematics behind statistical tests, but to focus on the logic, so that students can choose the most appropriate tests, apply them in the most convenient way and make sense of the results. Introductory chapters explain how to use statistical methods and then the tests are arranged according to the type of data that they require. Diagrams are used to guide students toward the most appropriate tests. The focus is on nonparametric methods that make very few assumptions and are appropriate for the kinds of data that many students will collect. Parametric methods, including Student's t-tests, correlation and regression are also covered. Although aimed directly at geography students at senior undergraduate and graduate level, this book provides an accessible introduction to a wide range of statistical methods and will be of value to students and researchers in allied disciplines including Earth and environmental science, and the social sciences.

Introduces the GUHA method of mechanizing hypothesis formation as a data mining tool. Presents examples of data mining with enhanced association rules, histograms, contingency tables and action rules. Provides examples of data mining for exception rules and examples of subgroups discovery. Outlines possibilities of GUHA in business intelligence and big data. Overviews related theoretical results and challenges related to mechanizing hypothesis formation.

Statistical Analysis of Contingency Tables is an invaluable tool for statistical inference in contingency tables. It covers effect size estimation, confidence intervals, and hypothesis tests for the binomial and the multinomial distributions, unpaired and paired 2x2 tables, rxc tables, ordered rx2 and 2xc tables, paired cxc tables, and stratified tables. For each type of table, key concepts are introduced, and a wide range of intervals and tests, including recent and unpublished methods and developments, are presented and evaluated. Topics such as diagnostic accuracy, inter-rater reliability, and missing data are also covered. The presentation is concise and easily accessible for readers with diverse professional backgrounds, with the mathematical details kept to a minimum. For more information, including a sample chapter and software, please visit the authors' website.

Making decisions is a ubiquitous mental activity in our private and professional or public lives. It entails choosing one course of action from an available shortlist of options. Statistics for Making Decisions places decision making at the centre of statistical inference, proposing its theory as a new paradigm for statistical practice. The analysis in this paradigm is earnest about prior information and the consequences of the various kinds of errors that may be committed. Its conclusion is a course of action tailored to the perspective of the specific client or sponsor of the analysis. The author's intention is a wholesale replacement of hypothesis testing, indicting it with the argument that it has no means of incorporating the consequences of errors which self-evidently matter to the client. The volume appeals to the analyst who deals with the simplest statistical problems of comparing two samples (which one has a greater mean or variance), or deciding whether a parameter is positive or negative. It combines highlighting the deficiencies of hypothesis testing with promoting a principled solution based on the idea of a currency for error, of which we want to spend as little as possible. This is implemented by selecting the option for which the expected loss is smallest (the Bayes rule). The price to pay is the need for a more detailed description of the options, and eliciting and quantifying the consequences (ramifications) of the errors. This is what our clients do informally and often inexpertly after receiving outputs of the analysis in an established format, such as the verdict of a hypothesis test or an estimate and its standard error. As a scientific discipline and profession, statistics has a potential to do this much better and deliver to the client a more complete and more relevant product. Nicholas T. Longford is a senior statistician at Imperial College, London, specialising in statistical methods for neonatal medicine. His interests include causal analysis of observational studies, decision theory, and the contest of modelling and design in data analysis. His longer-term appointments in the past include Educational Testing Service, Princeton, NJ, USA, de Montfort University, Leicester, England, and directorship of SNTL, a statistics research and consulting company. He is the author of over 100 journal articles and six other monographs on a variety of topics in applied statistics.

Features Probability models are developed from the shape of the sample empirical cumulative distribution function, (cdf) or a transformation of it. Bounds for the value of the population cumulative distribution function are obtained from the Beta distribution at each point of the empirical cdf. Bayes's theorem is developed from the properties of the screening test for a rare condition. The multinomial distribution provides an always-true model for any randomly sampled data. The model-free bootstrap method for finding the precision of a sample estimate has a model-based parallel - the Bayesian bootstrap - based on the always-true multinomial distribution. The Bayesian posterior distributions of model parameters can be obtained from the maximum likelihood analysis of the model.

This book describes the fundamental and theoretical concepts of optimization algorithms in a systematic manner, along with their potential applications and implementation strategies in mining engineering. It explains basics of systems engineering, linear programming, and integer linear programming, transportation and assignment algorithms, network analysis, dynamic programming, queuing theory and their applications to mine systems. Reliability analysis of mine systems, inventory management in mines, and applications of non-linear optimization in mines are discussed as well. All the optimization algorithms are explained with suitable examples and numerical problems in each of the chapters. Features include: * Integrates operations research, reliability, and novel computerized technologies in single volume, with a modern vision of continuous improvement of mining systems. * Systematically reviews optimization methods and algorithms applied to mining systems including reliability analysis. * Gives out software-based solutions such as MATLAB (R), AMPL, LINDO for the optimization problems. * All discussed algorithms are supported by examples in each chapter. * Includes case studies for performance improvement of the mine systems. This book is aimed primarily at professionals, graduate students, and researchers in mining engineering.

Reviews the literature of the Moth-Flame Optimization algorithm; Provides an in-depth analysis of equations, mathematical models, and mechanisms of the Moth-Flame Optimization algorithm; Proposes different variants of the Moth-Flame Optimization algorithm to solve binary, multi-objective, noisy, dynamic, and combinatorial optimization problems; Demonstrates how to design, develop, and test different hybrids of Moth-Flame Optimization algorithm; Introduces several applications areas of the Moth-Flame Optimization algorithm focusing in sustainability.

Association does not imply causation, yet some causal conclusions are firmly established based on associations found in observational studies. How does that happen? A study has two evidence factors if it provides two statistically independent tests of one causal hypothesis, susceptible to different biases. Two evidence factors can jointly provide quantifiably stronger evidence than either factor can provide on its own. The first book about evidence factors. Examples are drawn from epidemiology, economics, medical research and other fields. Data from these examples is available in a companion R package that reproduces many of the analyses. Self-contained, presenting needed background from causal inference, statistics and mathematics. Part 1 of the book presents concepts, methods and applications using limited mathematics. The theory of evidence factors is presented in a separate, second part of the book. Mathematics required for the theory is presented from the beginning.

Describes classical, basic sampling designs for spatial survey, as well as recently developed, advanced sampling designs and estimators Presents probability sampling designs for estimating parameters for a (sub)population, as well as non-probability sampling designs for mapping Gives comprehensive overview of model-assisted estimators Illustrates sampling designs with surveys of soil organic carbon, above-ground biomass, air temperature, opium poppy Explains integration of wall-to-wall data sets (e.g. remote sensing images) and sample data Data and R code available on github Exercises added making the book suitable as a textbook for students

Statistics For Dummies, 2nd Edition (9781119293521) was previously published as Statistics For Dummies, 2nd Edition (9780470911082). While this version features a new Dummies cover and design, the content is the same as the prior release and should not be considered a new or updated product. The fun and easy way to get down to business with statistics Stymied by statistics? No fear? this friendly guide offers clear, practical explanations of statistical ideas, techniques, formulas, and calculations, with lots of examples that show you how these concepts apply to your everyday life. Statistics For Dummies shows you how to interpret and critique graphs and charts, determine the odds with probability, guesstimate with confidence using confidence intervals, set up and carry out a hypothesis test, compute statistical formulas, and more. * Tracks to a typical first semester statistics course * Updated examples resonate with today's students * Explanations mirror teaching methods and classroom protocol Packed with practical advice and real-world problems, Statistics For Dummies gives you everything you need to analyze and interpret data for improved classroom or on-the-job performance.

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.

Written in recognition of developments in spatial data analysis that focused on differences between places, the first edition of Local Models for Spatial Analysis broke new ground with its focus on local modelling methods. Reflecting the continued growth and increased interest in this area, the second edition describes a wide range of methods which account for local variations in geographical properties. What's new in the Second Edition: Additional material on geographically-weighted statistics and local regression approaches A better overview of local models with reference to recent critical reviews about the subject area Expanded coverage of individual methods and connections between them Chapters have been restructured to clarify the distinction between global and local methods A new section in each chapter references key studies or other accounts that support the book Selected resources provided online to support learning An introduction to the methods and their underlying concepts, the book uses worked examples and case studies to demonstrate how the algorithms work their practical utility and range of application. It provides an overview of a range of different approaches that have been developed and employed within Geographical Information Science (GIScience). Starting with first principles, the author introduces users of GISystems to the principles and application of some widely used local models for the analysis of spatial data, including methods being developed and employed in geography and cognate disciplines. He discusses the relevant software packages that can aid their implementation and provides a summary list in Appendix A. Presenting examples from a variety of disciplines, the book demonstrates the importance of local models for all who make use of spatial data. Taking a problem driven approach, it pro