This book covers statistical consequences of breaches of research integrity such as fabrication and falsification of data, and researcher glitches summarized as questionable research practices. It is unique in that it discusses how unwarranted data manipulation harms research results and that questionable research practices are often caused by researchers' inadequate mastery of the statistical methods and procedures they use for their data analysis. The author's solution to prevent problems concerning the trustworthiness of research results, no matter how they originated, is to publish data in publicly available repositories and encourage researchers not trained as statisticians not to overestimate their statistical skills and resort to professional support from statisticians or methodologists. The author discusses some of his experiences concerning mutual trust, fear of repercussions, and the bystander effect as conditions limiting revelation of colleagues' possible integrity breaches. He explains why people are unable to mimic real data and why data fabrication using statistical models stills falls short of credibility. Confirmatory and exploratory research and the usefulness of preregistration, and the counter-intuitive nature of statistics are discussed. The author questions the usefulness of statistical advice concerning frequentist hypothesis testing, Bayes-factor use, alternative statistics education, and reduction of situational disturbances like performance pressure, as stand-alone means to reduce questionable research practices when researchers lack experience with statistics.

-Includes simplified statistical contents and step by step guide on how to apply the statistical concepts by perform analysis using SPSS together with interpretation of the statistical analysis output. -Provides a wide range of data sets to be used for examples and illustrations. -Designed to be accessible to readers with varied backgrounds.

Stochastic modeling is a set of quantitative techniques for analyzing practical systems with random factors. This area is highly technical and mainly developed by mathematicians. Most existing books are for those with extensive mathematical training; this book minimizes that need and makes the topics easily understandable. Fundamentals of Stochastic Models offers many practical examples and applications and bridges the gap between elementary stochastics process theory and advanced process theory. It addresses both performance evaluation and optimization of stochastic systems and covers different modern analysis techniques such as matrix analytical methods and diffusion and fluid limit methods. It goes on to explore the linkage between stochastic models, machine learning, and artificial intelligence, and discusses how to make use of intuitive approaches instead of traditional theoretical approaches. The goal is to minimize the mathematical background of readers that is required to understand the topics covered in this book. Thus, the book is appropriate for professionals and students in industrial engineering, business and economics, computer science, and applied mathematics.

This book aims to increase the visibility of data science in real-world, which differs from what you learn from a typical textbook. Many aspects of day-to-day data science work are almost absent from conventional statistics, machine learning, and data science curriculum. Yet these activities account for a considerable share of the time and effort for data professionals in the industry. Based on industry experience, this book outlines real-world scenarios and discusses pitfalls that data science practitioners should avoid. It also covers the big data cloud platform and the art of data science, such as soft skills. The authors use R as the primary tool and provide code for both R and Python. This book is for readers who want to explore possible career paths and eventually become data scientists. This book comprehensively introduces various data science fields, soft and programming skills in data science projects, and potential career paths. Traditional data-related practitioners such as statisticians, business analysts, and data analysts will find this book helpful in expanding their skills for future data science careers. Undergraduate and graduate students from analytics-related areas will find this book beneficial to learn real-world data science applications. Non-mathematical readers will appreciate the reproducibility of the companion R and python codes. Key Features: * It covers both technical and soft skills. * It has a chapter dedicated to the big data cloud environment. For industry applications, the practice of data science is often in such an environment. * It is hands-on. We provide the data and repeatable R and Python code in notebooks. Readers can repeat the analysis in the book using the data and code provided. We also suggest that readers modify the notebook to perform analyses with their data and problems, if possible. The best way to learn data science is to do it!

Librarians understand the need to store, use and analyze data related to their collection, patrons and institution, and there has been consistent interest over the last 10 years to improve data management, analysis, and visualization skills within the profession. However, librarians find it difficult to move from out-of-the-box proprietary software applications to the skills necessary to perform the range of data science actions in code. This book will focus on teaching R through relevant examples and skills that librarians need in their day-to-day lives that includes visualizations but goes much further to include web scraping, working with maps, creating interactive reports, machine learning, and others. While there’s a place for theory, ethics, and statistical methods, librarians need a tool to help them acquire enough facility with R to utilize data science skills in their daily work, no matter what type of library they work at (academic, public or special). By walking through each skill and its application to library work before walking the reader through each line of code, this book will support librarians who want to apply data science in their daily work. Hands-On Data Science for Librarians is intended for librarians (and other information professionals) in any library type (public, academic or special) as well as graduate students in library and information science (LIS). Key Features: Only data science book available geared toward librarians that includes step-by-step code examples Examples include all library types (public, academic, special) Relevant datasets Accessible to non-technical professionals Focused on job skills and their applications

● Materials tested over three years with several cohorts of students at different levels (UG and PGT), based on experiences teaching these materials to professional crime analysts, and developed by researchers with over 20 year experience teaching crime mapping. ● Very practical and embedded integration of criminological, spatial statistics, and cartographic concepts with the focus placed on lay understanding and development of intuition for ‘professional/applied research’ practice rather than in mathematical formulation and proof. ● Moves away from heavy US focus of competing alternatives. Datasets and examples used come from a variety of national contexts (including the US) which should broaden its appeal.

An Introduction to R and Python for Data Analysis helps teach students to code in both R and Python simultaneously. As both R and Python can be used in similar manners, it is useful and efficient to learn both at the same time, helping lecturers and students to teach and learn more, save time, whilst reinforcing the shared concepts and differences of the systems. This tandem learning is highly useful for students, helping them to become literate in both languages, and develop skills which will be handy after their studies. This book presumes no prior experience with computing, and is intended to be used by students from a variety of backgrounds. The side-by-side formatting of this book helps introductory graduate students quickly grasp the basics of R and Python, with the exercises providing helping them to teach themselves the skills they will need upon the completion of their course, as employers now ask for competency in both R and Python. Teachers and lecturers will also find this book useful in their teaching, providing a singular work to help ensure their students are well trained in both computer languages. All data for exercises can be found here: https://github.com/tbrown122387/r_and_python_book/tree/master/data. Key features: - Teaches R and Python in a "side-by-side" way. - Examples are tailored to aspiring data scientists and statisticians, not software engineers. - Designed for introductory graduate students. - Does not assume any mathematical background.

Statistic: A Concise Mathematical Introduction for Students and Scientists offers a one academic term text that prepares the student to broaden their skills in statistics, probability and inference, prior to selecting their follow-on courses in their chosen fields, whether it be engineering, computer science, programming, data sciences, business or economics. The book places focus early on continuous measurements, as well as discrete random variables. By invoking simple and intuitive models and geometric probability, discrete and continuous experiments and probabilities are discussed throughout the book in a natural way. Classical probability, random variables, and inference are discussed, as well as material on understanding data and topics of special interest. Topics discussed include: - Classical equally likely outcomes - Variety of models of discrete and continuous probability laws - Likelihood function and ratio - Inference - Bayesian statistics With the growth in the volume of data generated in many disciplines that is enabling the growth in data science, companies now demand statistically literate scientists and this textbook is the answer, suited for undergraduates studying science or engineering, be it computer science, economics, life sciences, environmental, business, amongst many others. Basic knowledge of bivariate calculus, R language, Matematica and JMP is useful, however there is an accompanying website including sample R and Mathematica code to help instructors and students.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. Features Offers first-hand, in-depth guidance on Mendelian randomization from leaders in the field Makes the diverse aspects of Mendelian randomization understandable to newcomers Illustrates technical details using data from applied analyses Discusses possible future directions for research involving Mendelian randomization Software code is provided in the relevant chapters and is also available at the supplementary website This book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

This unique textbook presents a course on computational linear algebra. Offers many unique applications. MATLAB is used throughout.

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.

Structural equation modeling (SEM) is a very general and flexible multivariate technique that allows relationships among variables to be examined. The roots of SEM are in the social sciences. In writing this textbook, the authors look to make SEM accessible to a wider audience of researchers across many disciplines, addressing issues unique to health and medicine. SEM is often used in practice to model and test hypothesized causal relationships among observed and latent (unobserved) variables, including in analysis across time and groups. It can be viewed as the merging of a conceptual model, path diagram, confirmatory factor analysis, and path analysis. In this textbook the authors also discuss techniques, such as mixture modeling, that expand the capacity of SEM using a combination of both continuous and categorical latent variables. Features: Basic, intermediate, and advanced SEM topics Detailed applications, particularly relevant for health and medical scientists Topics and examples that are pertinent to both new and experienced SEM researchers Substantive issues in health and medicine in the context of SEM Both methodological and applied examples Numerous figures and diagrams to illustrate the examples As SEM experts situated among clinicians and multidisciplinary researchers in medical settings, the authors provide a broad, current, on the ground understanding of the issues faced by clinical and health services researchers and decision scientists. This book gives health and medical researchers the tools to apply SEM approaches to study complex relationships between clinical measurements, individual and community-level characteristics, and patient-reported scales.

Monte-Carlo techniques have increasingly become a key method used in quantitative research. This book introduces engineers and scientists to the basics of using the Monte-Carlo simulation method which is used in Operations Research and other fields to understand the impact of risk and uncertainty in prediction and forecasting models. Monte-Carlo Simulation: An Introduction for Engineers and Scientists explores several specific applications in addition to illustrating the principles behind the methods. The question of accuracy and efficiency with using the method is addressed thoroughly within each chapter and all program listings are included in the discussion of each application to facilitate further research for the reader using Python programming language. Beginning engineers and scientists either already in or about to go into industry or commercial and government scientific laboratories will find this book essential. It could also be of interest to undergraduates in engineering science and mathematics, as well as instructors and lecturers who have no prior knowledge of Monte-Carlo simulations.

-Describes the basic ideas underlying each concept and model. -Includes R, SAS, SPSS and Stata programming codes for all the examples -Features significantly expanded Chapters 4, 5, and 8 (Chapters 4-6, and 9 in the second edition. -Expands discussion for subtle issues in longitudinal and clustered data analysis such as time varying covariates and comparison of generalized linear mixed-effect models with GEE.

This book is aimed to compile typical fundamental to advanced statistical methods to be used for health data sciences. This book promotes the applications to health and health-related data. However, the models in this book can be used to analyse any kind of data. The data are analysed with the commonly used statistical software of R/SAS (with online supplementary on SPSS/Stata). The data and computing programs will be available to facilitate readers' learning experience. There has been considerable attention to making statistical methods and analytics available to health data science researchers and students. This book brings it all together to provide a concise point-of-reference for most commonly used statistical methods from the fundamental level to the advanced level. We envisage this book will contribute to the rapid development in health data science. We provide straightforward explanations of the collected statistical theory and models, compilations of a variety of publicly available data, and illustrations of data analytics using commonly used statistical software of SAS/R. We will have the data and computer programs available for readers to replicate and implement the new methods. The primary readers would be applied data scientists and practitioners in any field of data science, applied statistical analysts and scientists in public health, academic researchers, and graduate students in statistics and biostatistics. The secondary readers would be R&D professionals/practitioners in industry and governmental agencies. This book can be used for both teaching and applied research.

Easy-to-Use Reference and Software for Statistical Modeling and Testing Handbook of Statistical Distributions with Applications, Second Edition provides quick access to common and specialized probability distributions for modeling practical problems and performing statistical calculations. Along with many new examples and results, this edition includes both the author's StatCalc software and R codes to accurately and easily carry out computations. New to the Second Edition Major changes in binomial, Poisson, normal, gamma, Weibull, exponential, logistic, Laplace, and Pareto distributions Updated statistical tests and intervals based on recent publications in statistical journals Enhanced PC calculator StatCalc with electronic help manuals R functions for cases where StatCalc is not applicable, with the codes available online This highly praised handbook integrates popular probability distribution models, formulas, applications, and software to help you compute a variety of statistical intervals. It covers probability and percentiles, algorithms for random number generation, hypothesis tests, confidence intervals, tolerance intervals, prediction intervals, sample size determination, and much more.

Dynamic Time Series Models using R-INLA: An Applied Perspective is the outcome of a joint effort to systematically describe the use of R-INLA for analysing time series and showcasing the code and description by several examples. This book introduces the underpinnings of R-INLA and the tools needed for modelling different types of time series using an approximate Bayesian framework. The book is an ideal reference for statisticians and scientists who work with time series data. It provides an excellent resource for teaching a course on Bayesian analysis using state space models for time series. Key Features: Introduction and overview of R-INLA for time series analysis. Gaussian and non-Gaussian state space models for time series. State space models for time series with exogenous predictors. Hierarchical models for a potentially large set of time series. Dynamic modelling of stochastic volatility and spatio-temporal dependence.

Review of the First Edition: The authors strive to reduce theory to a minimum, which makes it a self-learning text that is comprehensible for biologists, physicians, etc. who lack an advanced mathematics background. Unlike in many other textbooks, R is not introduced with meaningless toy examples; instead the reader is taken by the hand and shown around some analyses, graphics, and simulations directly relating to meta-analysis... A useful hands-on guide for practitioners who want to familiarize themselves with the fundamentals of meta-analysis and get started without having to plough through theorems and proofs. -Journal of Applied Statistics Statistical Meta-Analysis with R and Stata, Second Edition provides a thorough presentation of statistical meta-analyses (MA) with step-by-step implementations using R/Stata. The authors develop analysis step by step using appropriate R/Stata functions, which enables readers to gain an understanding of meta-analysis methods and R/Stata implementation so that they can use these two popular software packages to analyze their own meta-data. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data are introduced. The authors then develop analysis code using the appropriate R/Stata packages and functions. What's New in the Second Edition: Adds Stata programs along with the R programs for meta-analysis Updates all the statistical meta-analyses with R/Stata programs Covers fixed-effects and random-effects MA, meta-regression, MA with rare-event, and MA-IPD vs MA-SS Adds five new chapters on multivariate MA, publication bias, missing data in MA, MA in evaluating diagnostic accuracy, and network MA Suitable as a graduate-level text for a meta-data analysis course, the book is also a valuable reference for practitioners and biostatisticians (even those with little or no experience in using R or Stata) in public health, medical research, governmental agencies, and the pharmaceutical industry.

Illustrate the usefulness and abuse of statistics in automotive safety arguments that are hidden from public view Show the importance of data and statistics in making safety-related changes that ultimately save or cost lives Discuss the impact of electric vehicles and autonomous vehicles on car safety

Modern ecological and environmental sciences are dominated by observational data. As a result, traditional statistical training often leaves scientists ill-prepared for the data analysis tasks they encounter in their work. Bayesian methods provide a more robust and flexible tool for data analysis, as they enable information from different sources to be brought into the modelling process. Bayesian Applications in Evnironmental and Ecological Studies with R and Stan provides a Bayesian framework for model formulation, parameter estimation, and model evaluation in the context of analyzing environmental and ecological data. Features: An accessible overview of Bayesian methods in environmental and ecological studies Emphasizes the hypothetical deductive process, particularly model formulation Necessary background material on Bayesian inference and Monte Carlo simulation Detailed case studies, covering water quality monitoring and assessment, ecosystem response to urbanization, fisheries ecology, and more Advanced chapter on Bayesian applications, including Bayesian networks and a change point model Complete code for all examples, along with the data used in the book, are available via GitHub The book is primarily aimed at graduate students and researchers in the environmental and ecological sciences, as well as environmental management professionals. This is a group of people representing diverse subject matter fields, who could benefit from the potential power and flexibility of Bayesian methods.

This book has been prepared to help psychiatrists expand their knowledge of statistical methods and fills the gaps in their applications as well as introduces data analysis software. The book emphasizes the classification of fundamental statistical methods in psychiatry research that are precise and simple. Professionals in the field of mental health and allied subjects without any mathematical background can easily understand all the relevant statistical methods and carry out the analysis and interpret the results in their respective fields without consulting a statistician.

The sequence of the chapters, the sections within the chapters, the subsections within the sections, and the points within the subsections have all been arranged to help professionals in classification refine their knowledge in statistical methods and fill the gaps, if any.

Emphasizing simplicity, the fundamental statistical methods are demonstrated by means of arithmetical examples that may be reworked with pencil and paper in a matter of minutes. The results of the rework have to be checked by using SPSS, and in this way professionals are introduced to this psychiatrist-friendly data analysis software.

Topics covered include:

An overview of psychiatry research

The organization and collection of data

Descriptive statistics

The basis of statistical inference

Tests of significance

Correlational data analysis

Multivariate data analysis

Meta-analysis

Reporting the results

Statistical software

The language of the book is very simple and covers all aspects of statistical methods starting from organization and collection of data to descriptive statistics, statistical inference, multivariate analysis, and meta-analysis. Two chapters on computer applications deal with the most popular data analysis software: SPSS.

The book will be very valuable to professionals and post-graduate students in psychiatry and allied fields, such as psychiatric social work, clinical psychology, psychiatric nursing, and mental health education and administration.

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With the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development. However, the available literature on this important topic is sporadic, and often not readily accessible to drug developers or regulatory personnel. This book provides a systematic exposition of the interplay between the two disciplines, including emerging themes pertaining to the acceleration of the development of pharmaceutical medicines to serve patients with unmet needs. Features: Regulatory and statistical interactions throughout the drug development continuum The critical role of the statistician in relation to the changing regulatory and healthcare landscapes Statistical issues that commonly arise in the course of drug development and regulatory interactions Trending topics in drug development, with emphasis on current regulatory thinking and the associated challenges and opportunities The book is designed to be accessible to readers with an intermediate knowledge of statistics, and can be a useful resource to statisticians, medical researchers, and regulatory personnel in drug development, as well as graduate students in the health sciences. The authors' decades of experience in the pharmaceutical industry and academia, and extensive regulatory experience, comes through in the many examples throughout the book.

The use of Electronic Health Records (EHR)/Electronic Medical Records (EMR) data is becoming more prevalent for research. However, analysis of this type of data has many unique complications due to how they are collected, processed and types of questions that can be answered. This book covers many important topics related to using EHR/EMR data for research including data extraction, cleaning, processing, analysis, inference, and predictions based on many years of practical experience of the authors. The book carefully evaluates and compares the standard statistical models and approaches with those of machine learning and deep learning methods and reports the unbiased comparison results for these methods in predicting clinical outcomes based on the EHR data. Key Features: Written based on hands-on experience of contributors from multidisciplinary EHR research projects, which include methods and approaches from statistics, computing, informatics, data science and clinical/epidemiological domains. Documents the detailed experience on EHR data extraction, cleaning and preparation Provides a broad view of statistical approaches and machine learning prediction models to deal with the challenges and limitations of EHR data. Considers the complete cycle of EHR data analysis. The use of EHR/EMR analysis requires close collaborations between statisticians, informaticians, data scientists and clinical/epidemiological investigators. This book reflects that multidisciplinary perspective.

Principles of Copula Theory explores the state of the art on copulas and provides you with the foundation to use copulas in a variety of applications. Throughout the book, historical remarks and further readings highlight active research in the field, including new results, streamlined presentations, and new proofs of old results. After covering the essentials of copula theory, the book addresses the issue of modeling dependence among components of a random vector using copulas. It then presents copulas from the point of view of measure theory, compares methods for the approximation of copulas, and discusses the Markov product for 2-copulas. The authors also examine selected families of copulas that possess appealing features from both theoretical and applied viewpoints. The book concludes with in-depth discussions on two generalizations of copulas: quasi- and semi-copulas. Although copulas are not the solution to all stochastic problems, they are an indispensable tool for understanding several problems about stochastic dependence. This book gives you the solid and formal mathematical background to apply copulas to a range of mathematical areas, such as probability, real analysis, measure theory, and algebraic structures.

Provides a thorough coverage and comparison of a wide array of time series models and methods: Exponential Smoothing, Holt Winters, ARMA and ARIMA, deep learning models including RNNs, LSTMs, GRUs, and ensemble models composed of combinations of these models. Introduces the factor table representation of ARMA and ARIMA models. This representation is not available in any other book at this level and is extremely useful in both practice and pedagogy. Uses real world examples that can be readily found via web links from sources such as the US Bureau of Statistics, Department of Transportation and the World Bank. There is an accompanying R package that is easy to use and requires little or no previous R experience. The package implements the wide variety of models and methods presented in the book and has tremendous pedagogical use.