The Bayesian network is one of the most important architectures for representing and reasoning with multivariate probability distributions. When used in conjunction with specialized informatics, possibilities of real-world applications are achieved. Probabilistic Methods for BioInformatics explains the application of probability and statistics, in particular Bayesian networks, to genetics. This book provides background material on probability, statistics, and genetics, and then moves on to discuss Bayesian networks and applications to bioinformatics.

Rather than getting bogged down in proofs and algorithms, probabilistic methods used for biological information and Bayesian networks are explained in an accessible way using applications and case studies. The many useful applications of Bayesian networks that have been developed in the past 10 years are discussed. Forming a review of all the significant work in the field that will arguably become the most prevalent method in biological data analysis.
Unique coverage of probabilistic reasoning methods applied to bioinformatics data--those methods that are likely to become the standard analysis tools for bioinformatics.Shares insights about when and why probabilistic methods can and cannot be used effectively; Complete review of Bayesian networks and probabilistic methods with a practical approach.

This book first presents an overview of the history of a national character survey by the Institute of Statistical Mathematics that has been conducted for more than 65 years. The Japanese National Character Survey, launched in 1953, is a rare longitudinal survey in the world of survey research based on rigorous statistical sampling theory, motivating other countries to launch similar longitudinal surveys, including the General Social Survey (GSS), the Allgemeine Bevoelkerungsumfrage der Sozialwissenschaften (ALLBUS, German General Social Survey (GGSS)), Eurobarometer, and others. Since the early 1970s, the Japanese survey has been extended as a cross-national survey for more advanced research of the Japanese national character in a comparative context. Second, the book explains the paradigm of cross-national studies called the Cultural Manifold Analysis (CULMAN), developed in the longitudinal and cross-national surveys, with practical examples of analysis. This explanation will help helps a wide range of readers to better understand the cross-national comparative surveys of attitudes, opinion, and social values as basic information for evidence-based policymaking and research.

This book discusses recent developments in dynamic reliability in multi-state systems (MSS), addressing such important issues as reliability and availability analysis of aging MSS, the impact of initial conditions on MSS reliability and availability, changing importance of components over time in MSS with aging components, and the determination of age-replacement policies. It also describes modifications of traditional methods, such as Markov processes with rewards, as well as a modern mathematical method based on the extended universal generating function technique, the Lz-transform, presenting various successful applications and demonstrating their use in real-world problems. This book provides theoretical insights, information on practical applications, and real-world case studies that are of interest to engineers and industrial managers as well as researchers. It also serves as a textbook or supporting text for graduate and postgraduate courses in industrial, electrical, and mechanical engineering.

This book presents a systematic treatment of the Rademacher system, one of the most important unifying concepts in mathematics, and includes a number of recent important and beautiful results related to the Rademacher functions. The book discusses the relationship between the properties of the Rademacher system and geometry of some function spaces. It consists of three parts, in which this system is considered respectively in Lp-spaces, in general symmetric spaces and in certain classes of non-symmetric spaces (BMO, Paley, Cesaro, Morrey). The presentation is clear and transparent, providing all main results with detailed proofs. Moreover, literary and historical comments are given at the end of each chapter. This book will be suitable for graduate students and researchers interested in functional analysis, theory of functions and geometry of Banach spaces.

This book offers a new look at well-established quantification theory for categorical data, referred to by such names as correspondence analysis, dual scaling, optimal scaling, and homogeneity analysis. These multiple identities are a consequence of its large number of properties that allow one to analyze and visualize the strength of variable association in an optimal solution. The book contains modern quantification theory for analyzing the association between two and more categorical variables in a variety of applicative frameworks. Visualization has attracted much attention over the past decades and given rise to controversial opinions. One may consider variations of plotting systems used in the construction of the classic correspondence plot, the biplot, the Carroll-Green-Schaffer scaling, or a new approach in doubled multidimensional space as presented in the book. There are even arguments for no visualization at all. The purpose of this book therefore is to shed new light on time-honored graphical procedures with critical reviews, new ideas, and future directions as alternatives. This stimulating volume is written with fresh new ideas from the traditional framework and the contemporary points of view. It thus offers readers a deep understanding of the ever-evolving nature of quantification theory and its practice. Part I starts with illustrating contingency table analysis with traditional joint graphical displays (symmetric, non-symmetric) and the CGS scaling and then explores logically correct graphs in doubled Euclidean space for both row and column variables. Part II covers a variety of mathematical approaches to the biplot strategy in graphing a data structure, providing a useful source for this modern approach to graphical display. Part II is also concerned with a number of alternative approaches to the joint graphical display such as bimodal cluster analysis and other statistical problems relevant to quantification theory.

This book provides readers with a comprehensive and recent exposition in deep learning and its multidisciplinary applications, with a concentration on advances of deep learning architectures. The book discusses various artificial intelligence (AI) techniques based on deep learning architecture with applications in natural language processing, semantic knowledge, forecasting and many more. The authors shed light on various applications that can benefit from the use of deep learning in pattern recognition, person re-identification in surveillance videos, action recognition in videos, image and video captioning. The book also highlights how deep learning concepts can be interwoven with more modern concepts to yield applications in multidisciplinary fields. Presents a comprehensive look at deep learning and its multidisciplinary applications, concentrating on advances of deep learning architectures; Includes a survey of deep learning problems and solutions, identifying the main open issues, innovations and latest technologies; Shows industrial deep learning in practice with examples/cases, efforts, challenges, and strategic approaches.

This handbook is focused on the analytical dimension in researching international entrepreneurship. It offers a diverse collection of chapters focused on qualitative and quantitative methods that are being practised and can be used by future researchers in the field of international entrepreneurship. The qualitative cluster covers articles, conceptual and empirical chapters as well as literature reviews, whereas the quantitative cluster analyses international entrepreneurship through a broad range of statistical methods such as regressions, panel data, structural equation modelling as well as decision-making and optimisation models in certain and uncertain circumstances. This book is essential reading for researchers, scholars and practitioners who want to learn and implement new methods in analysing entrepreneurial opportunities across national borders.

This book contains international perspectives that unifies the themes of strategic management, decision theory, and data science. It contains thought-provoking presentations of case studies backed by adequate analysis adding significance to the discussions. Most of the decision-making models in use do take due advantage of collection and processing of relevant data using appropriate analytics oriented to provide inputs into effective decision-making. The book showcases applications in diverse fields including banking and insurance, portfolio management, inventory analysis, performance assessment of comparable economic agents, managing utilities in a health-care facility, reducing traffic snarls on highways, monitoring achievement of some of the sustainable development goals in a country or state, and similar other areas that showcase policy implications. It holds immense value for researchers as well as professionals responsible for organizational decisions.

This proceedings book presents state-of-the-art developments in theory, methodology, and applications of network analysis across sociology, computational science, education research, literature studies, political science, international relations, social media research, and urban studies. The papers comprising this collection were presented at the Fifth 'Networks in the Global World' conference organized by the Centre for German and European Studies of St. Petersburg University and Bielefeld University and held on July 7-9, 2020. This biannual conference series revolves around key interdisciplinary issues in the focus of network analysts, such as the multidimensional approach to social reality, translation of theories and methods across disciplines, and mixing of data and methods. The distinctive features of this book are the emphasis on in-depth linkages between theory, method, and applications, the blend of qualitative and quantitative methods, and the joint consideration of different network levels, types, and contexts. The topics covered by the papers include interrelation of social and cultural structures, constellations of power, and patterns of interaction in areas ranging from various types of communities (local, international, educational, political, and so on) to social media and literature. The book is useful for practicing researchers, graduate and postgraduate students, and educators interested in network analysis of social relations, politics, economy, and culture. Features that set the book apart from others in the field: * The book offers a unique cross-disciplinary blend of computational and ethnographic network analyses applied to a diverse spectrum of spheres, from literature and education to urban planning and policymaking. * Embracing conceptual, methodological, and empirical works, the book is among the few in network analysis to emphasize connections between theory, method, and applications. * The book brings together authors and empirical contexts from all over the globe, with a particular emphasis on European societies.

This book presents the theory and methods of flexible and generalized uncertainty optimization. Particularly, it describes the theory of generalized uncertainty in the context of optimization modeling. The book starts with an overview of flexible and generalized uncertainty optimization. It covers uncertainties that are both associated with lack of information and are more general than stochastic theory, where well-defined distributions are assumed. Starting from families of distributions that are enclosed by upper and lower functions, the book presents construction methods for obtaining flexible and generalized uncertainty input data that can be used in a flexible and generalized uncertainty optimization model. It then describes the development of the associated optimization model in detail. Written for graduate students and professionals in the broad field of optimization and operations research, this second edition has been revised and extended to include more worked examples and a section on interval multi-objective mini-max regret theory along with its solution method.

This book provides a practical guide to the analysis of data from randomized controlled trials (RCT). It gives an answer to the question of how to estimate the intervention effect in an appropriate way. This problem is examined for different RCT designs, such as RCTs with one follow-up measurement, RCTs with more than one follow-up measurement, cluster RCTs, cross-over trials, stepped wedge trials, and N-of-1 trials. The statistical methods are explained in a non-mathematical way and are illustrated by extensive examples. All datasets used in the book are available for download, so readers can reanalyse the examples to gain a better understanding of the methods used. Although most examples are taken from epidemiological and clinical studies, this book is also highly recommended for researchers working in other fields.

Structural Equation Modeling provides a conceptual and mathematical understanding of structural equation modelling, helping readers across disciplines understand how to test or validate theoretical models, and build relationships between observed variables. In addition to a providing a background understanding of the concepts, it provides step-by-step illustrative applications with AMOS, SPSS and R software programmes. This volume will serve as a useful reference for academic and industry researchers in the fields of engineering, management, psychology, sociology, human resources, and humanities.

This book offers an overview of the statistical methods used in clinical and observational vaccine studies. Pursuing a practical rather than theoretical approach, it presents a range of real-world examples with SAS codes, making the application of the methods straightforward. This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data. In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies. The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.

This book takes a fresh look at the popular and well-established method of maximum likelihood for statistical estimation and inference. It begins with an intuitive introduction to the concepts and background of likelihood, and moves through to the latest developments in maximum likelihood methodology, including general latent variable models and new material for the practical implementation of integrated likelihood using the free ADMB software. Fundamental issues of statistical inference are also examined, with a presentation of some of the philosophical debates underlying the choice of statistical paradigm. Key features: * Provides an accessible introduction to pragmatic maximum likelihood modelling. * Covers more advanced topics, including general forms of latent variable models (including non-linear and non-normal mixed-effects and state-space models) and the use of maximum likelihood variants, such as estimating equations, conditional likelihood, restricted likelihood and integrated likelihood. * Adopts a practical approach, with a focus on providing the relevant tools required by researchers and practitioners who collect and analyze real data. * Presents numerous examples and case studies across a wide range of applications including medicine, biology and ecology. * Features applications from a range of disciplines, with implementation in R, SAS and/or ADMB. * Provides all program code and software extensions on a supporting website. * Confines supporting theory to the final chapters to maintain a readable and pragmatic focus of the preceding chapters. This book is not just an accessible and practical text about maximum likelihood, it is a comprehensive guide to modern maximum likelihood estimation and inference. It will be of interest to readers of all levels, from novice to expert. It will be of great benefit to researchers, and to students of statistics from senior undergraduate to graduate level. For use as a course text, exercises are provided at the end of each chapter.

This book offers essential, systematic information on the assessment of the spatial association between two processes from a statistical standpoint. Divided into eight chapters, the book begins with preliminary concepts, mainly concerning spatial statistics. The following seven chapters focus on the methodologies needed to assess the correlation between two or more processes; from theory introduced 35 years ago, to techniques that have only recently been published. Furthermore, each chapter contains a section on R computations to explore how the methodology works with real data. References and a list of exercises are included at the end of each chapter. The assessment of the correlation between two spatial processes has been tackled from several different perspectives in a variety of applications fields. In particular, the problem of testing for the existence of spatial association between two georeferenced variables is relevant for posterior modeling and inference. One evident application in this context is the quantification of the spatial correlation between two images (processes defined on a rectangular grid in a two-dimensional space). From a statistical perspective, this problem can be handled via hypothesis testing, or by using extensions of the correlation coefficient. In an image-processing framework, these extensions can also be used to define similarity indices between images.

Box and Jenkins (1970) made the idea of obtaining a stationary time series by differencing the given, possibly nonstationary, time series popular. Numerous time series in economics are found to have this property. Subsequently, Granger and Joyeux (1980) and Hosking (1981) found examples of time series whose fractional difference becomes a short memory process, in particular, a white noise, while the initial series has unbounded spectral density at the origin, i.e. exhibits long memory.Further examples of data following long memory were found in hydrology and in network traffic data while in finance the phenomenon of strong dependence was established by dramatic empirical success of long memory processes in modeling the volatility of the asset prices and power transforms of stock market returns.At present there is a need for a text from where an interested reader can methodically learn about some basic asymptotic theory and techniques found useful in the analysis of statistical inference procedures for long memory processes. This text makes an attempt in this direction. The authors provide in a concise style a text at the graduate level summarizing theoretical developments both for short and long memory processes and their applications to statistics. The book also contains some real data applications and mentions some unsolved inference problems for interested researchers in the field.

The first edition of this classic book has become the authoritative reference for physicists desiring to master the finer points of statistical data analysis. This second edition contains all the important material of the first, much of it unavailable from any other sources. In addition, many chapters have been updated with considerable new material, especially in areas concerning the theory and practice of confidence intervals, including the important Feldman?Cousins method. Both frequentist and Bayesian methodologies are presented, with a strong emphasis on techniques useful to physicists and other scientists in the interpretation of experimental data and comparison with scientific theories. This is a valuable textbook for advanced graduate students in the physical sciences as well as a reference for active researchers.

This volume presents new methods and applications in longitudinal data estimation methodology in applied economic. Featuring selected papers from the 2020 the International Conference on Applied Economics (ICOAE 2020) held virtually due to the corona virus pandemic, this book examines interdisciplinary topics such as financial economics, international economics, agricultural economics, marketing and management. Country specific case studies are also featured.

This book takes the reader through real-world examples for how to characterize and measure the productivity and performance of NFPs and education institutions-that is, organisations that produce value for society, which cannot be measured accurately in financial KPIs. It focuses on how best to frame non-profit performance and productivity, and provides a suite of tools for measurement and benchmarking. It further challenges the reader to consider alternative and appropriate uses of quantitative measures, which are fit-for-purpose in individual contexts. It is true that the risk of misusing quantitative measures is ever-present. But does that risk outweigh the benefits of forming a more precise and shared understanding of what could generate better outcomes? There will always be concerns about policy and performance management. Goodheart's Law states that once a measure becomes a target, it is no longer a good measure. This book helps to strike a meaningful balance between what can be measured, what cannot, and how best to use quantitative information in sectors that are often averse to being held up to the light and put on a scale by outsiders.

For one-semester business statistics courses. A focus on using statistical methods to analyse and interpret results to make data-informed business decisions Statistics is essential for all business majors, and Business Statistics: A First Course helps students see the role statistics will play in their own careers by providing examples drawn from all functional areas of business. Guided by the principles set forth by major statistical and business science associations (ASA and DSI), plus the authors' diverse experiences, the 8th Edition, Global Edition, continues to innovate and improve the way this course is taught to all students. With new examples, case scenarios, and problems, the text continues its tradition of focusing on the interpretation of results, evaluation of assumptions, and discussion of next steps that lead to data-informed decision making. The authors feel that this approach, rather than a focus on manual calculations, better serves students in their future careers. This brief offering, created to fit the needs of a one-semester course, is part of the established Berenson/Levine series.

This is an introductory statistics book designed to provide scientists with practical information needed to apply the most common statistical tests to laboratory research data. The book is designed to be practical and applicable, so only minimal information is devoted to theory or equations. Emphasis is placed on the underlying principles for effective data analysis and survey the statistical tests. It is of special value for scientists who have access to Minitab software. Examples are provides for all the statistical tests and explanation of the interpretation of these results presented with Minitab (similar to results for any common software package). The book is specifically designed to contribute to the AAPS series on advances in the pharmaceutical sciences. It benefits professional scientists or graduate students who have not had a formal statistics class, who had bad experiences in such classes, or who just fear/don't understand statistics. Chapter 1 focuses on terminology and essential elements of statistical testing. Statistics is often complicated by synonyms and this chapter established the terms used in the book and how rudiments interact to create statistical tests. Chapter 2 discussed descriptive statistics that are used to organize and summarize sample results. Chapter 3 discussed basic assumptions of probability, characteristics of a normal distribution, alternative approaches for non-normal distributions and introduces the topic of making inferences about a larger population based on a small sample from that population. Chapter 4 discussed hypothesis testing where computer output is interpreted and decisions are made regarding statistical significance. This chapter also deasl with the determination of appropriate sample sizes. The next three chapters focus on tests that make decisions about a population base on a small subset of information. Chapter 5 looks at statistical tests that evaluate where a significant difference exists. In Chapter 6 the tests try to determine the extent and importance of relationships. In contrast to fifth chapter, Chapter 7 presents tests that evaluate the equivalence, not the difference between levels being tested. The last chapter deals with potential outlier or aberrant values and how to statistically determine if they should be removed from the sample data. Each statistical test presented includes an example problem with the resultant software output and how to interpret the results. Minimal time is spent on the mathematical calculations or theory. For those interested in the associated equations, supplemental figures are presented for each test with respective formulas. In addition, Appendix D presents the equations and proof for every output result for the various examples. Examples and results from the appropriate statistical results are displayed using Minitab 18O. In addition to the results, the required steps to analyze data using Minitab are presented with the examples for those having access to this software. Numerous other software packages are available, including based data analysis with Excel.

Quantum mechanics is arguably one of the most successful scientific theories ever and its applications to chemistry, optics, and information theory are innumerable. This book provides the reader with a rigorous treatment of the main mathematical tools from harmonic analysis which play an essential role in the modern formulation of quantum mechanics. This allows us at the same time to suggest some new ideas and methods, with a special focus on topics such as the Wigner phase space formalism and its applications to the theory of the density operator and its entanglement properties. This book can be used with profit by advanced undergraduate students in mathematics and physics, as well as by confirmed researchers.

A First Course in Stochastic Calculus is a complete guide for advanced undergraduate students to take the next step in exploring probability theory and for master's students in mathematical finance who would like to build an intuitive and theoretical understanding of stochastic processes. This book is also an essential tool for finance professionals who wish to sharpen their knowledge and intuition about stochastic calculus. Louis-Pierre Arguin offers an exceptionally clear introduction to Brownian motion and to random processes governed by the principles of stochastic calculus. The beauty and power of the subject are made accessible to readers with a basic knowledge of probability, linear algebra, and multivariable calculus. This is achieved by emphasizing numerical experiments using elementary Python coding to build intuition and adhering to a rigorous geometric point of view on the space of random variables. This unique approach is used to elucidate the properties of Gaussian processes, martingales, and diffusions. One of the book's highlights is a detailed and self-contained account of stochastic calculus applications to option pricing in finance.