This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments - particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials - Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power - A Non-proportional Hazards Perspective.

This book discusses the theory, methods, and applications of flow of funds analysis. The book integrates the basic principles of economic statistics, financial accounts, international finance, econometric models, and financial network analysis, providing a systematic and comprehensive introduction to the interconnection between these research fields. It thus provides the reader with the intellectual groundwork indispensable for understanding the workings and interactions of today's globalized financial markets. The main focus of the book is how to observe the flow of funds in macroeconomics, how to measure the global flow of funds (GFF), and how to use GFF data to carry out an analysis. Based on the statistical framework for measuring GFF under the System of National Accounts, the book identifies the systematic relationship of financial linkages among economic sectors and with the rest of the world while integrating data sources that include stock data, geographically broken down by country-region, and selected financial instruments. It sets out the GFF concept and constructs a GFF matrix (metadata) on a from-whom-to-whom basis within a country-by-country pattern. Lastly, an established GFF matrix table is used to conduct an empirical study including an econometric model and financial network analysis.

Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.

Applying Contemporary Statistical Techniques explains why traditional statistical methods are often inadequate or outdated when applied to modern problems. Wilcox demonstrates how new and more powerful techniques address these problems far more effectively, making these modern robust methods understandable, practical, and easily accessible.
* Assumes no previous training in statistics
* Explains how and why modern statistical methods provide more accurate results than conventional methods
* Covers the latest developments on multiple comparisons
* Includes recent advances in risk-based methods
* Features many illustrations and examples using data from real studies
* Describes and illustrates easy-to-use s-plus functions for applying cutting-edge techniques
* Covers many contemporary ANOVA (analysis of variance) and regression methods not found in other books

Survival analysis arises in many fields of study including medicine, biology, engineering, public health, epidemiology, and economics. This book provides a comprehensive treatment of Bayesian survival analysis. Several topics are addressed, including parametric models, semiparametric models based on prior processes, proportional and non-proportional hazards models, frailty models, cure rate models, model selection and comparison, joint models for longitudinal and survival data, models with time varying covariates, missing covariate data, design and monitoring of clinical trials, accelerated failure time models, models for multivariate survival data, and special types of hierarchical survival models. Also various censoring schemes are examined including right and interval censored data. Several additional topics are discussed, including noninformative and informative prior specificiations, computing posterior qualities of interest, Bayesian hypothesis testing, variable selection, model selection with nonnested models, model checking techniques using Bayesian diagnostic methods, and Markov chain Monte Carlo (MCMC) algorithms for sampling from the posteiror and predictive distributions. The book presents a balance between theory and applications, and for each class of models discussed, detailed examples and analyses from case studies are presented whenever possible. The applications are all essentially from the health sciences, including cancer, AIDS, and the environment. The book is intended as a graduate textbook or a reference book for a one semester course at the advanced masters or Ph.D. level. This book would be most suitable for second or third year graduate students in statistics or biostatistics. It would also serve as a useful reference book for applied or theoretical researchers as well as practitioners. Joseph G. Ibrahim is Associate Professor of Biostatistics at the Harvard School of Public Health and Dana-Farber Cancer Institute; Ming-Hui Chen is Associate Professor of Mathematical Science at Worcester Polytechnic Institute; Debajyoti Sinha is Associate Professor of Biostatistics at the Medical University of South Carolina.

Immediately implementable code, with extensive and varied illustrations of graph variants and layouts. Examples and exercises across a variety of real-life contexts including business, politics, education, social media and crime investigation. Dedicated chapter on graph visualization methods. Practical walkthroughs of common methodological uses: finding influential actors in groups, discovering hidden community structures, facilitating diverse interaction in organizations, detecting political alignment, determining what influences connection and attachment. Various downloadable data sets for use both in class and individual learning projects. Final chapter dedicated to individual or group project examples.

Clustering is an important unsupervised classification technique where data points are grouped such that points that are similar in some sense belong to the same cluster. Cluster analysis is a complex problem as a variety of similarity and dissimilarity measures exist in the literature. This is the first book focused on clustering with a particular emphasis on symmetry-based measures of similarity and metaheuristic approaches. The aim is to find a suitable grouping of the input data set so that some criteria are optimized, and using this the authors frame the clustering problem as an optimization one where the objectives to be optimized may represent different characteristics such as compactness, symmetrical compactness, separation between clusters, or connectivity within a cluster. They explain the techniques in detail and outline many detailed applications in data mining, remote sensing and brain imaging, gene expression data analysis, and face detection. The book will be useful to graduate students and researchers in computer science, electrical engineering, system science, and information technology, both as a text and as a reference book. It will also be useful to researchers and practitioners in industry working on pattern recognition, data mining, soft computing, metaheuristics, bioinformatics, remote sensing, and brain imaging.

Since Charles Spearman published his seminal paper on factor analysis in 1904 and Karl Joresk ] og replaced the observed variables in an econometric structural equation model by latent factors in 1970, causal modelling by means of latent variables has become the standard in the social and behavioural sciences. Indeed, the central va- ables that social and behavioural theories deal with, can hardly ever be identi?ed as observed variables. Statistical modelling has to take account of measurement - rors and invalidities in the observed variables and so address the underlying latent variables. Moreover, during the past decades it has been widely agreed on that serious causal modelling should be based on longitudinal data. It is especially in the ?eld of longitudinal research and analysis, including panel research, that progress has been made in recent years. Many comprehensive panel data sets as, for example, on human development and voting behaviour have become available for analysis. The number of publications based on longitudinal data has increased immensely. Papers with causal claims based on cross-sectional data only experience rejection just for that reason."

This work considers Kronecker-based models with finite as well as countably infinite state spaces for multidimensional Markovian systems by paying particular attention to those whose reachable state spaces are smaller than their product state spaces. Numerical methods for steady-state and transient analysis of Kronecker-based multidimensional Markovian models are discussed in detail together with implementation issues. Case studies are provided to explain concepts and motivate use of methods. Having grown out of research from the past twenty years, this book expands upon the author's previously published book Analyzing Markov Chains using Kronecker Products (Springer, 2012). The subject matter is interdisciplinary and at the intersection of applied mathematics and computer science. The book will be of use to researchers and graduate students with an understanding of basic linear algebra, probability, and discrete mathematics.

An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance to marketing to astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, deep learning, survival analysis, multiple testing, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform. Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra. This Second Edition features new chapters on deep learning, survival analysis, and multiple testing, as well as expanded treatments of naive Bayes, generalized linear models, Bayesian additive regression trees, and matrix completion. R code has been updated throughout to ensure compatibility.

The first edition of Multivariate Statistical Modelling provided an extension of classical models for regression, time series, and longitudinal data to a much broader class including categorical data and smoothing concepts. Generalized linear modesl for univariate and multivariate analysis build the central concept, which for the modelling of complex data is widened to much more general modelling approaches. The primary aim of the new edition is to bring the book up-to-date and to reflect the major new developments over the past years. The authors give a detailed introductory survey of the subject based on the alaysis of real data drawn from a variety of subjects, including the biological sciences, economics, and the social sciences. Technical details and proofs are deferred to an appendix in order to provide an accessible account for non-experts. The appendix serves as a reference or brief tutorial for the concepts of EM algorithm, numberical integration, MCMC and others. The topics covered inlude: Models for multi-categorial responses, model checking, semi- and nonparametric modelling, time series and longitudinal data, random effects models, state-space models, and survival analysis. In the new edition Bayesian concepts which are of growing importance in statistics are treated more extensively. The chapter on nonparametric and semiparametric generalized regression has been rewritten totally, random effects models now cover nonparametric maximum likelihood and fully Bayesian approaches, and state-space and hidden Markov models have been supplemented with an extension to models that can accommodate for spatial and spatiotemporal data. The authors have taken great pains to discuss the underlying theoretical ideas in ways that relate well to the data at hand. As a result, this book is ideally suited for applied statisticians, graduate students of statistics, and students and researchers with a strong interest in statistics and data analysis from econometrics, biometrics and the social sciences.

Stochastic Analysis aims to provide mathematical tools to describe and model high dimensional random systems. Such tools arise in the study of Stochastic Differential Equations and Stochastic Partial Differential Equations, Infinite Dimensional Stochastic Geometry, Random Media and Interacting Particle Systems, Super-processes, Stochastic Filtering, Mathematical Finance, etc. Stochastic Analysis has emerged as a core area of late 20th century Mathematics and is currently undergoing a rapid scientific development. The special volume "Stochastic Analysis 2010" provides a sample of the current research in the different branches of the subject. It includes the collected works of the participants at the Stochastic Analysis section of the 7th ISAAC Congress organized at Imperial College London in July 2009.

This book presents a unified theory of rare event simulation and the variance reduction technique known as importance sampling from the point of view of the probabilistic theory of large deviations. It allows us to view a vast assortment of simulation problems from a unified single perspective.

Thiscollectionofproblemsisplannedasatextbookforuniversitycoursesinthe theoryofstochasticprocessesandrelatedspecialcourses. Theproblemsinthebook haveawidespectrumofthelevelofdif cultyandcanbeusefulforreaderswith variouslevelsofmasteringinthetheoryofstochasticprocesses. Togetherwithte- nicalandillustrativeproblemsintendedforbeginners,thebookcontainsanumber ofproblemsoftheoreticalnaturethatcanbeusefulforstudentsandundergraduate studentsthatpursueadvancedstudiesinthetheoryofstochasticprocessesandits- plications. Amongothers,theimportantaimofthebookistoprovideateachingstaff anef cienttoolforpreparingseminarstudies,tests,andexamsconcerninguniversity coursesinthetheoryofstochasticprocessesandrelatedtopics. Whilecomposingthe book,theauthorshavepartiallyusedthecollectionsofproblemsinprobabilityt- ory[16,65,75,83]. Also,someexercisesandproblemsfromthemonographsand textbooks[4,9,19,22,82]wereused. Atthesametime,alargepartofourproblem bookcontainsoriginalmaterial. Thebookisorganizedasfollows. Theproblemsarecollectedintochapters,each chapterbeingdevotedtoacertaintopic. Atthebeginningofeachchapter,theth- reticalgroundsforthecorrespondingtopicaregivenbrie ytogetherwiththelistof bibliography,whichthereadercanuseinordertostudythistopicinmoredetail. For themostoftheproblems,eitherhintsorcompletesolutions(oranswers)aregiven, andsomeoftheproblemsareprovidedwithbothhintsandsolutions(answers). H- ever,theauthorsdonotrecommendthatareaderusethehintssystematically,because solvingaproblemwithoutassistanceismuchmoreusefulthanusingaready-made idea. Somestatementsthathaveaparticulartheoreticalinterestareformulatedon theoreticalgrounds,andtheirproofsareformulatedasproblemsforthereader. Such problemsaresuppliedwitheithercompletesolutionsordetailedhints. Inordertoworkwiththeproblembookef ciently,areadershouldbeacquainted withprobabilitytheory,calculus,andmeasuretheorywithinthescopeofresp- tiveuniversity courses. Standard notions, suchas random variable, measurability, independence, Lebesgue measure and integral, and so on are used without ad- tionaldiscussion. Allthenewnotionsandstatementsrequiredforsolvingthepr- lemsaregiveneitherontheoreticalgroundsorintheformulationsoftheproblems vii viii Preface straightforwardly. However,sometimesanotionisusedinthetextbeforeitsformal de nition. Forinstance,theWienerandPoissonprocessesareprocesseswithin- pendentincrementsandthusareformallyintroducedinaTheoreticalgroundsfor Chapter5,buttheseprocessesareusedwidelyintheproblemsofChapters2to4. Theauthorsrecommendthatareaderwhocomestoanunknownnotionorobject usetheIndexinorderto ndthecorrespondingformalde nition. Thesamerec- mendationconcernssomestandardabbreviationsandsymbolslistedattheendofthe book. Someproblemsinthebookformcycles:solutionstooneofthemaregrounded onstatementsofothersoronauxiliaryconstructionsdescribedinsomepreceding solutions. Sometimes,onthecontrary,itisproposedtoprovethesamestatement withindifferentproblemsusingessentiallydifferenttechniques. Theauthorsrec- mendareaderpayspeci cattentiontothesefruitfulinternallinksbetweenvarious topicsofthetheoryofstochasticprocesses. Everypartofthebookwascomposedsubstantiallybyoneauthor. Chapters1-6, and16arecomposedbyA. Kulik,Chapters7,12-15,18,and19byYu. Mishura, Chapters 8-10 by A. Pilipenko, Chapter 17 by A. Kukush, and Chapter 20 by D. Gusak. Chapter11waspreparedjointlybyD. GusakandA. Pilipenko. Atthe sametime,everyauthorhasmadeacontributiontootherpartsofthebookbyprop- ingseparateproblemsorcyclesofproblems,improvingpreliminaryversionsoft- oreticalgrounds,andeditingthe naltext. The authors would like to express their deep gratitude to M. Portenko and A. Ivanovfortheircarefulreadingofapreliminaryversionofthebookandva- ablecommentsthatledtosigni cantimprovementofthetext. Theauthorsarealso gratefultoT. Yakovenko,G. Shevchenko,O. Soloveyko, Yu. Kartashov, Yu. K- menko,A. Malenko,andN. Ryabovafortheirassistanceintranslation,preparing lesandpictures,andcomposingthesubjectindexandreferences. Thetheoryofstochasticprocessesisanextendeddiscipline,andtheauthors- derstandthattheproblembookinitscurrentformmaycausecriticalremarksfrom readers,concerningeitherthestructureofthebookorthecontentofseparatech- ters. Whilepublishingtheproblembookinitscurrentform,theauthorsareopenfor remarks,comments,andpropositions,andexpressinadvancetheirgratitudetoall theircorrespondents. Kyiv DmytroGusak December2008 AlexanderKukush AlexeyKulik YuliyaMishura AndreyPilipenko Contents 1 De?nition of stochastic process. Cylinder?-algebra, ?nite-dimensional distributions, the Kolmogorov theorem...1 Theoreticalgrounds ...1 Bibliography...3 Problems...3 Hints...7 AnswersandSolutions...9 2 Characteristics of a stochastic process. Mean and covariance functions. Characteristic functions...11 Theoreticalgrounds ...11 Bibliography...13 Problems...13 Hints...16 AnswersandSolutions...17 3 Trajectories. Modi?cations. Filtrations...21 Theoreticalgrounds ...21 Bibliography...24 Problems...24 Hints...29 AnswersandSolutions...31 4 Continuity. Differentiability. Integrability...33 Theoreticalgrounds ...33 Bibliography...34 Problems...34 Hints...38 AnswersandSolutions...40 ix x Contents 5 Stochastic processes with independent increments. Wiener and Poisson processes. Poisson point measures...

Explanatory Model Analysis Explore, Explain and Examine Predictive Models is a set of methods and tools designed to build better predictive models and to monitor their behaviour in a changing environment. Today, the true bottleneck in predictive modelling is neither the lack of data, nor the lack of computational power, nor inadequate algorithms, nor the lack of flexible models. It is the lack of tools for model exploration (extraction of relationships learned by the model), model explanation (understanding the key factors influencing model decisions) and model examination (identification of model weaknesses and evaluation of model's performance). This book presents a collection of model agnostic methods that may be used for any black-box model together with real-world applications to classification and regression problems.

The emphasis of this textbook is on industrial applications of Statistical Measurement Theory. It deals with the principal issues of measurement theory, is concise and intelligibly written, and to a wide extent self-contained. Difficult theoretical issues are separated from the mainstream presentation. Each topic starts with an informal introduction followed by an example, the rigorous problem formulation, solution method, and a detailed numerical solution. Each chapter concludes with a set of exercises of increasing difficulty, mostly with solutions. The book is meant as a text for graduate students and a reference for researchers and industrial experts specializing in measurement and measurement data analysis for quality control, quality engineering and industrial process improvement using statistical methods. Knowledge of calculus and fundamental probability and statistics is required for the understanding of its contents.

With the boom of big data and machine learning and the subsequent need for parallel processing technologies, fork-join queues are more relevant now than ever before. In this book, new estimates of the average response time in fork-join queues are proposed, which form the basis for new research opportunities. Analysis of Fork-Join Systems: Network of Queues with Precedence Constraints explores numerical approaches to estimate the average response time of fork-join queueing networks and offers never before published simple expressions for the mean response time as conjectures. Extensive experiments are included to demonstrate the remarkable accuracy of the conjectures and algorithms used in the estimation of the average response time. Graduate students, professors, and researchers in the fields of operations research, management science, industrial engineering, computer science, and electrical engineering will find this book very useful. Students, as well as researchers in both academia and industry, will also find this book of great help when looking for results related to fork-join queues

This book includes best selected, high-quality research papers presented at International Conference on Data Driven Computing and IoT (DDCIoT 2021) organized jointly by Geetanjali Institute of Technical Studies (GITS), Udaipur, and Rajasthan Technical University, Kota, India, during March 20-21, 2021. This book presents influential ideas and systems in the field of data driven computing, information technology, and intelligent systems.

Frederick Mosteller has inspired numerous statisticians and other scientists by his creative approach to statistics and its applications. This volume brings together 40 of his most original and influential papers, capturing the variety and depth of his writings. The editors hope to share these with a new generation of researchers, so that they can build upon his insights and efforts. This volume of selected papers is a companion to the earlier volume A Statistical Model: Frederick Mosteller's Contributions to Statistics, Science, and Public Policy, edited by Stephen E. Fienberg, David C. Hoaglin, William H. Kruskal, and Judith M. Tanur (Springer-Verlag, 1990), and to Mosteller's forthcoming autobiography, which will also be published by Springer-Verlag. It includes a biography and a comprehensive bibliography of Mosteller's books, papers, and other writings. Stephen E. Fienberg is Maurice Falk University Professor of Statistics and Social Science, in the Departments of Statistics and Machine Learning at Carnegie Mellon University, Pittsburgh, PA. David C. Hoaglin is Principal Scientist at Abt Associates Inc., Cambridge, MA.

Water engineers require knowledge of stochastic, frequency concepts, uncertainty analysis, risk assessment, and the processes that predict unexpected events.

This book presents the basics of stochastic, risk and uncertainty analysis, and random sampling techniques in conjunction with straightforward examples which are solved step by step. In addition, appropriate Excel functions are included as an alternative to solve the examples, and two real case studies is presented in the last chapters of book.

This research-level book presents up-to-date information concerning recent developments in convex functions and partial orderings and some applications in mathematics, statistics, and reliability theory. The book will serve researchers in mathematical and statistical theory and theoretical and applied reliabilists.
Key Features
* Presents classical and newly published results on convex functions and related inequalities
* Explains partial ordering based on arrangement and their applications in mathematics, probability, statsitics, and reliability
* Demonstrates the connection of partial ordering with other well-known orderings such as majorization and Schur functions
* Will generate further research and applications

This book gives a comprehensive introduction to the modeling of financial derivatives, covering all major asset classes (equities, commodities, interest rates and foreign exchange) and stretching from Black and Scholes' lognormal modeling to current-day research on skew and smile models. The intended reader has a solid mathematical background and is a graduate/final-year undergraduate student specializing in Mathematical Finance, or works at a financial institution such as an investment bank or a hedge fund.

This book presents a selection of peer-reviewed contributions on the latest advances in time series analysis, presented at the International Conference on Time Series and Forecasting (ITISE 2019), held in Granada, Spain, on September 25-27, 2019. The first two parts of the book present theoretical contributions on statistical and advanced mathematical methods, and on econometric models, financial forecasting and risk analysis. The remaining four parts include practical contributions on time series analysis in energy; complex/big data time series and forecasting; time series analysis with computational intelligence; and time series analysis and prediction for other real-world problems. Given this mix of topics, readers will acquire a more comprehensive perspective on the field of time series analysis and forecasting. The ITISE conference series provides a forum for scientists, engineers, educators and students to discuss the latest advances and implementations in the foundations, theory, models and applications of time series analysis and forecasting. It focuses on interdisciplinary research encompassing computer science, mathematics, statistics and econometrics.

Promptly growing demand for telecommunication services and information interchange has led to the fact that communication became one of the most dynamical branches of an infrastructure of a modern society. The book introduces to the bases of classical MDP theory; problems of a finding optimal CAC in models are investigated and various problems of improvement of characteristics of traditional and multimedia wireless communication networks are considered together with both classical and new methods of theory MDP which allow defining optimal strategy of access in teletraffic systems. The book will be useful to specialists in the field of telecommunication systems and also to students and post-graduate students of corresponding specialties.

Any financial asset that is openly traded has a market price. Except for extreme market conditions, market price may be more or less than a fair value. Fair value is likely to be some complicated function of the current intrinsic value of tangible or intangible assets underlying the claim and our assessment of the characteristics of the underlying assets with respect to the expected rate of growth, future dividends, volatility, and other relevant market factors. Some of these factors that affect the price can be measured at the time of a transaction with reasonably high accuracy. Most factors, however, relate to expectations about the future and to subjective issues, such as current management, corporate policies and market environment, that could affect the future financial performance of the underlying assets. Models are thus needed to describe the stochastic factors and environment, and their implementations inevitably require computational finance tools.