Tackle the core component of your T Level with this comprehensive resource published in association with City & Guilds. With topic coverage ranging from the principles of construction science and design to workplace relationship management, this book provides complete coverage of the Onsite Construction qualification's core units and will equip you with the skills you need to shape your career. - Break down complex topics with summary tables and hundreds of images and artworks - Apply your knowledge in real-world case studies and discover some of the dilemmas you can expect to face in the workplace - Re-cap knowledge and understanding with 'Key terms' and 'Test yourself' features, as well as a detailed glossary - Prepare for your exams and the employer-set project using practice questions and project practice exercises - Develop the functional skills you need to thrive in the industry with English and maths exercises - Understand how to avoid hazards and minimise risk with regular health and safety reminders - Hone core skills with expert authors Mike Jones, Stephen Jones, Tom Leahy and Peter Tanner, who draw on their extensive teaching and industry experience

Optimizing the process of converting heat into mechanical power is a major challenge when it comes to meeting targets for protecting primary energy resources and minimizing our environmental impact. For many years to come, the use of thermal engines will continue to be necessary for transportation on land, by sea and by air, as well as for many industrial applications. Against this background, Thermodynamics of Heat Engines aims to present a comprehensive overview of the thermodynamic concepts, including combustion, that are necessary for understanding the phenomena governing the energy efficiency of internal and external combustion engines as well as that of gas turbines and jet propulsion engines. Existing and developing industrial applications, based on combined heat and power (CHP) or the use of staged cycles, are presented, with particular attention paid to the recovery of low temperature waste heat. This book, which is mainly intended for university and engineering students but is also useful for engineers and technicians working in the fields concerned, provides a basis for reflection on the optimization of energy systems.

IN "THE ANTIDOTE," Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company's tumultuous early days during the AIDS crisis in "The Billion-Dollar Molecule," a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325 billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twentyfive- year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, "The Antidote" is a powerful inside look at one of the most intriguing and important business stories of recent decades.

According to the World Health Organization, one in every ten people worldwide falls ill from eating contaminated food every year, with 550 million cases of diarrheal diseases. Microbiological risk assessment aims to characterize the nature and probability of harm resulting from human exposure to the biological agents that are present in foodstuffs. This assessment must take into account all stages of the chain: from the production of raw materials to consumption. After briefly introducing food safety and risk assessment, this book details the four major steps of microbiological risk assessment. The contributors first present hazard identification and then exposure assessment, which is subdivided into methods for the detection and enumeration of pathogens and for the quantification of the level of exposure. Then, hazard characterization is subdivided into pathogenicity mechanisms and quantification of the dose-response relationship. Finally a guide for microbiological risk characterization is provided. The conclusion presents possible development avenues for microbiological risk assessment, particularly its integration into a holistic assessment of food systems.

In this engaging account of innovative triumphs, Guru Madhavan examines the ways in which engineers throughout history created world-changing tools, from ATMs and ZIP codes to the digital camera and the disposable diaper. Equal parts personal, practical, and profound, Applied Minds charts a path to a future where we borrow strategies from engineering to find inspired solutions to our most pressing challenges.

Drastic improvements in both access to satellite images and data processing tools today allow near real-time observation of Earth surface deformations. Remote sensing imagery is thus a powerful, reliable and spatially dense source of information that can be used to understand the Earth and its surface manifestations as well as mitigate natural hazards. This book offers for the first time a complete overview of the methodological approaches developed to measure surface displacement using synthetic aperture radar (SAR) and optical imagery, as well as their applications in the monitoring of major geophysical phenomena. More specifically, the first part of the book presents the theory behind SAR interferometry (InSAR) and image correlation and its latest developments. In the second part, most of the geophysical phenomena that trigger Earth surface deformations are reviewed. Surface Displacement Measurement from Remote Sensing Images unveils the potential and sensitivity of the measurement of Earth surface displacements from remote sensing imagery.