|
Books > Medicine > Clinical & internal medicine > Renal medicine
Offering practical guidance for all members of the transplant team,
Kidney Transplantation, Principles and Practice, 8th Edition,
provides the balanced, up-to-date information you need to achieve
optimal outcomes for your patients. A global team of
internationally renowned surgeons and nephrologists, many new to
this edition, offers fresh perspectives on everything from applied
science and surgical techniques to immunosuppressive methods,
outcomes, risks, and medical considerations related to kidney
transplantation, in both adults and children. Offers
state-of-the-art coverage of all areas of kidney transplantation
such as preservation of kidneys; mechanisms of rejection and the
induction of tolerance; techniques of laparoscopic live donor
nephrectomy; and immunosuppression. Contains up-to-date outcomes
data and analysis of the evidence supporting current practice in
the field. Includes new information on desensitization and
considerable new data on the clinical use of costimulation
blockade. Keeps you current with new chapters on kidney allocation
policy that reflects the ethical and societal values of different
countries and populations; and biomarkers of kidney injury and
rejection, including the need for better monitoring tools to guide
therapy and patient management. Covers hot topics such as
management of chronic allograft failure, the sensitized patient and
antibody-mediated rejection, and paired exchange principles.
Features hundreds of superb illustrations to help you visualize key
concepts and nuances of renal transplantation. Provides dynamic
visual guidance with new real-time video coverage of
ultrasound-guided pancreas allograft biopsy; a new animation of
calcineurin inhibitor mechanism of action animation; and videos
that demonstrate the formation of an immune synapse, 3-D rotational
images of immune synapses, an NK cell killing its target,
peritoneal dialysis-catheter insertion techniques, laparoendoscopic
single site (LESS) donor nephrectomy, and more. Enhanced eBook
version included with purchase, which allows you to access all of
the text, figures, and references from the book on a variety of
devices
The kidney is innervated with efferent sympathetic nerve fibers
reaching the renal vasculature, the tubules, the juxtaglomerular
granular cells, and the renal pelvic wall. The renal sensory nerves
are mainly found in the renal pelvic wall. Increases in efferent
renal sympathetic nerve activity reduce renal blood flow and
urinary sodium excretion by activation of 1-adrenoceptors and
increase renin secretion rate by activation of 1-adrenoceptors. In
response to normal physiological stimulation, changes in efferent
renal sympathetic nerve activity contribute importantly to
homeostatic regulation of sodium and water balance. The renal
mechanosensory nerves are activated by stretch of the renal pelvic
tissue produced by increases in renal pelvic tissue of a magnitude
that may occur during increased urine flow rate. Under normal
conditions, the renal mechanosensory nerves activated by stretch of
the sensory nerves elicits an inhibitory renorenal reflex response
consisting of decreases in efferent renal sympathetic nerve
activity leading to natriuresis. Increasing efferent sympathetic
nerve activity increases afferent renal nerve activity which, in
turn, decreases efferent renal sympathetic nerve activity by
activation of the renorenal reflexes. Thus, activation of the
afferent renal nerves buffers changes in efferent renal sympathetic
nerve activity in the overall goal of maintaining sodium balance.
In pathological conditions of sodium retention, impairment of the
inhibitory renorenal reflexes contributes to an inappropriately
increased efferent renal sympathetic nerve activity in the presence
of sodium retention. In states of renal disease or injury, there is
a shift from inhibitory to excitatory reflexes originating in the
kidney. Studies in essential hypertensive patients have shown that
renal denervation results in long-term reduction in arterial
pressure, suggesting an important role for the efferent and
afferent renal nerves in hypertension.
Medical Semiology Guide of the Renal System provides a
comprehensive understanding of medical semiology in the renal
system. Highly illustrated with many original images from the
author's daily medical practice, the book highlights all signs of
diseases and important semiological maneuvers in the field. Each
chapter incorporates a specific questionnaire with important
questions that should be asked to patients in different situations
to obtain valuable information that helps identify rare and unusual
diseases. This unique feature of the book aims to facilitate the
learning process among medical students, while also acting as a
quick reference guide for clinicians in practice.
Adenocarcinoma is the predominant malignancy found in the colon and
rectum. Colorectal cancer is the third most common cancer diagnosed
in the developed world with a high incidence of mortality and
morbidity. The average five-year survival rate remains poor at 55%,
although the development of new drugs has improved the survival
rate of colorectal cancer patients. The prognosis of colorectal
cancer remains poor in spite of the development of novel
therapeutic strategies. Human colorectal cancer represents a
heterogeneous group of diseases, and its molecular classification
is increasingly important. Characterization of novel biomarker
targets may lead to prolong the survival rate of colorectal cancer.
Biomarkers may have a potential role in screening, diagnosis,
prognosis and monitoring disease. Mutations in the KRAS gene in
~40% of tumors have been reported to be induced by genetic and
epigenetic alterations. This book, comprised of four chapters,
introduces recent topics regarding colorectal cancer, and provides
recent highlighted information concerning prevention, diagnosis and
treatment. This book will be of interest to undergraduate and
graduate students, biomedical researchers, and medical doctors
focused on the fields of molecular and cellular biology, medical
sciences, and clinical challenges.
In consultation with Consulting Editor, Dr. Stephen Krau, Dr.
Farrar and Dr. Ellison have created an issue that focuses on
evidence-based clinical updates and innovations in various
nephrology disorders. Top experts on the topic have contributed
reviews on the follwoing topics: Kidney Influence on Fluids and
Electrolytes; Renal Diet; Pharmacologic Renal Therapy; Acute Renal
Therapy; Chronic Renal Therapy; Innovations in Kidney; Autoimmune
Disease; Infection-Related Glomerular Disease; Sclerotic Diseases;
Obstructive Renal Diseases; Chronic Renal Complications;
Psychosocial Issues and Life Style Changes for the Renal Patient;
and Withdrawal of Treatment (end of life decisions). Authors will
come away with the clinical knowledge they need to improve outcomes
in the nephrotic patient.
From basic science to practical clinical tools, Chronic Kidney
Disease, Dialysis, and Transplantation, 4th Edition provides you
with the up-to-date, authoritative guidance you need to safely and
effectively manage patients with chronic renal disease. Covering
all relevant clinical management issues, this companion volume to
Brenner and Rector's The Kidney presents the knowledge and
expertise of renowned researchers and clinicians in the fields of
hemodialysis, peritoneal dialysis, critical care nephrology, and
transplantation - for an all-in-one, indispensable guide to every
aspect of this fast-changing field. Contains expanded content on
economics and outcomes of treatment, as well as acute kidney
injury. Covers hot topics such as the genetic causes of chronic
kidney disease, ethical challenges and palliative care, and home
hemodialysis. Discusses the latest advances in hypertensive kidney
disease, vitamin D deficiency, diabetes management,
transplantation, and more. Provides a clear visual understanding of
complex information with high-quality line drawings, photographs,
and diagnostic and treatment algorithms. Expert ConsultT eBook
version included with purchase. This enhanced eBook experience
allows you to search all of the text, figures, and references from
the book on a variety of devices.
Kidney Development and Disease brings together established and
young investigators who are leading authorities in nephrology to
describe recent advances in three primary areas of research. The
first section describes the use of animal models as powerful tools
for the discovery of numerous molecular mechanisms regulating
kidney development. The second section focuses on nephric cell
renewal and differentiation, which lead to diverse cell fates
within the developing kidney, and discusses diseases resulting from
the aberrant regulation of the balance between cell fate decisions.
The final section concentrates on morphogenesis of the developing
kidney and its maintenance after formation as well as the diseases
resulting from failures in these processes. Kidney form and
function have been extensively studied for centuries, leading to
discoveries related to their development and disease. Recent
scientific advances in molecular and imaging techniques have
broadened our understanding of nephron development and maintenance
as well as the diseases related to these processes.
Recent work has begun to elucidate at the molecular level how
albumin is handled by the kidney and how albuminuria develops in
various proteinuric diseases including minimal change disease and
focal segmental glomerulosclerosis. This volume provides a
comprehensive overview of the renal handling of albumin - from
basic mechanisms to the pathophysiology of proteinuric diseases. In
describing the basic mechanisms of albuminuria, a particular
highlight will be the focus on advanced imaging techniques such as
intravital microscopy that have allowed a detailed "window" into
albumin transit through the kidney. The volume will cover the
epidemiological studies which show that albuminuria is a strong and
independent marker of kidney disease progression and cardiovascular
events, the molecular details of albumin handling in the kidney at
the level of the glomerulus and the proximal tubule and the
pathophysiology of proteinuric diseases including minimal change
disease, membranous nephropathy, focal segmental glomerulosclerosis
and diabetic nephropathy.
|
|