For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.

Oncofertility is a specialty that bridges the disciplines of reproductive endocrinology and infertility and oncology, with the goal of expanding the reproductive options of cancer patients. Given fertility risks associated with specific cancer treatments, as well as the improved long-term survival made possible by these therapies, there has been growing interest in expanding reproductive options for cancer patients. Indeed, both cancer survivors and the medical community have acknowledged the importance of patient counseling and the pursuit of fertility preservation options prior to starting cancer treatment. Oncofertility Medical Practice: Clinical Issues and Implementation is the third in a series of timely and indispensable books on fertility preservation for cancer patients-the first one focused on advances in basic science research and the second one offered ethical, legal, and social perspectives on the theme. This book elucidates the latest practices and emerging treatments in oncofertility and provides necessary information on the successes, risks, and limitations of fertility preserving technologies. Authoritative and insightful, written by an impressive multi-disciplinary cadre of specialists, this book is a valuable up-to-date resource for all those practicing in this demanding field. "This excellent text is an invaluable resource and a "must read" for clinicians and researchers interested in Oncofertility. The editors and authors need to be congratulated for their fine work." Roger A. Lobo, MD, Professor of Obstetrics and Gynecology, Columbia University and Past President of the American Society for Reproductive Medicine

Artificial Insemination and Treatment of Infertility in Dairy Animals by Honnappagol and Tandle is a handy work of 16 well experienced faculties drawn from different departments of higher learning. Most of them are actively engaged in under-graduate and post-graduate teaching with considerable expertise. Adequate care has been exercised by the editors to incorporate all the aspects of artificial insemination and infertility in the chapters form 1 to 20 so that it can serve as a real guide to the students and veterinarians and in turn minimizing the possible economic losses to the dairy animal owners and dairy Industry. Adequate care has been taken to include all spheres of infertility starting from endocrinology of estrous cycle, role of nutrition, feed formulation, breeding strategies, estrus detection aids, recent advances in reproduction controlled breeding, fertility improvement use of ultrasound and laparoscopy, therapeutic management of infertility and reproductive disease control. Practical knowledge and skill in respect of handling, storage and evaluation of frozen semen, safety handling of cryocans and liquid nitrogen, factors affecting success rate in artificial insemination programme and drugs and hormones used in treating reproductive disorders is also provided.

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded Third Edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicologya (TM)s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.

This ground-breaking resource includes:

• New and important critical mechanistic topics such as epigenetics and omics
• The first significant compilation of epigenetic mechanisms
• An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
• New guidelines with respect to the latest research applications in the field

In this book, leading academics and practitioners in the field of reproductive health address topics such as contraception, abortion, sexually transmitted infections, maternal and prenatal health, sexuality and reproductive rights by examining a number of critical issues in these areas. The authors describe new research, identify gaps and priorities in policy and practice, and illustrate innovative solutions. The book further addresses such current imperatives as understanding the social meanings of emergency contraception, measuring gender-based violence, improving reproductive health governance, strengthening health systems and services, and redressing institutional barriers. The book also assesses how reproductive health programs can be reconfigured to new challenges such as those posed by climate change, vulnerable youth in fragile states, and risks from new infertility treatments. Using a rich and varied set of cases, a broad public health and social science perspective, and novel methodological approaches, this book questions common assumptions, illustrates effective solutions and sets out research, policy, and programmatic agendas for the present and future. This is a comprehensive volume which provides a valuable resource to researchers, educators, practitioners, policymakers and students, as well as anyone studying or advocating for reproductive health.

It is not okay to call something a miracle without even trying to understand it. This is human developmental biology (human embryology, in terms of cells and molecules) for everyone curious enough to see it through, from the perspective of the business of becoming human - as individuals and as species; making new humans; how it happens (cells do it, ALL of it); and common variations of the process.It cannot be made quite simple and be kept quite true, but we will move as far toward simple as we can without losing touch with sound evidence. Variations from the "normal" version of the process, particularly malformations and twinning and chimerism, figure prominently in the story because there is no better way to learn about the usual than to study the unusual and see what differences in the endings these observable differences at the beginnings can make.In this book, when technical terminology is the only way, or the best way, to say what needs to be said, it is defined and explained - making the words a worthwhile part of what is here to be learned.This book defines its own new field. We cannot claim to understand how anything [human] works [as human], with no effort at understanding the emergence of its form and functions. Old and new unanswered questions are waiting to be dug out from under old unquestioned answers about how becoming human unfolds. We will also address some popular and weighty, but deeply empty assertions about the circumstances and mechanisms of our beginnings and our ceaseless becoming. We will find fundamental questions from 'the humanities' unanswerable except from biology. Human developmental biology is a foundational discipline within the humanities.

Genetic Screening and Counseling is reviewed in this issue of Obstetrics and Gynecology Clinics, guest edited by Drs. Anthony R. Gregg and Joe Leigh Simpson. Authorities in the field have come together to pen articles on Contemporary Genetics Counseling: New Frontiers and Challenges, Newborn Screening, SMA Carrier Screening, Fragile X, Ashkenazi Jewish Screening in the 21st Century, Thrombophilia in Obstetric Practice, Microarrays in the Practice of Obstetrics and Gynecology, Cancer Genetic Screening, and Cystic Fibrosis.

This reference work on andrology begins with a discussion of male infertility. It discusses genetic causes, conventional treatment, non-surgical methods for sperm retrieval, and assisted reproduction techniques. It also covers andrological endocrinology with chapters on clinical investigation and laboratory analysis in male hypogonadism, as well as testosterone deficiency syndrome. Additional topics include urogentical infections and STDs, erectile dysfunction, psychological abnormalities of male sexual function, and reproductive cancers. The book emphasizes contemporary concern for evidence-based practice, minimizing interventions, and promoting male reproductive health.

Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.

If you're taking an undergraduate or postgraduate medical courses, or similar courses in other related disciplines, this is the book for you. Embryology is a concise and highly illustrated text, covering only the descriptions you really need to know. An appreciation of embryology is essential to understand topological relationships in gross anatomy and to explain many congenital anomalies. Text in concise Illustrated Colour Text style, so core information on embryology can be quickly recognised and digested. Clear full colour diagrams and pictures make the embryological concepts clear and easily assimilated. Clinical boxes highlight essential points of importance to medical students.

Andrology is the fastest growing subspecialty in urology and has recently achieved remarkable advances in the understanding of the erectile mechanism and in reproductive medicine. Male Infertility and Sexual Dysfunction presents all the current avenues of treatment with emphasis on multidisciplinary considerations. Chapters are written by select international authorities presenting indepth coverage of their areas of expertise. Each topic will cover the background, anatomy, physiology, diagnosis, classification, and treatment (medical and/or surgical). Part I focuses on the study of male infertility and includes discussions of the basic sciences, office evaluation, laboratory and imaging techniques, and the use of testicular biopsy. This is followed by specialized chapters dealing with immunologic infertility, genital inflammation, reactive oxygen species, medical management, sperm processing and preventive adolescent andrology. Part II reflects a more diverse format in the coverage of sexual dysfunction and includes discussions of androgen insufficiency, nocturnal penile tumescence studies, neurotransmission, penile neurology, premature ejaculation, psychogenic impotence and the latest medical, noninvasive and surgical treatments.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

This cutting-edge text for surgeons specializing in Reproductive Medicine details how the latest minimally invasive developments impact on operations in their repertoire. Illustrated with color photographs and surgical videos, this will be an essential reference in a fast-moving field.

Unlike other areas of medicine where statistics are meticulously kept by governments and global organizations, there are no accurate data to describe the number of the world's inhabitants who are overweight, obese, or morbidly obese. Despite this knowledge deficit, it should come as no surprise to readers that the medical community is facing an epidemic. Obesity is present in many of the developed countries and can also be observed in some urban areas of developing nations. The cause of this epidemic, simply stated, is overeating, but the overriding concern is more complex. Social factors, such as growing affluence since the 1950s, increasing reliance on pre-prepared meals, and the popularity of fast foods and sweetened drinks, have all contributed to the problem. Without doubt, the obesity epidemic has had adverse effects on both men and women, but in the case of women, some of its worse complications occur with those who are severely obese and pregnant. Obviously, this combination has been seen in the past, but it has increased so dramatically in its frequency that research has yet to catch up. Studies may discuss one or another aspect of caring for the obese pregnant patient, but until now, there has been no attempt to draw all such material together to try and present a comprehensive appraisal of the problem. Written by international experts, this practical guide draws on evidence-based material and is an invaluable resource for healthcare professionals dealing with obese pregnant women on a day-to-day basis.

Fetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease.

This book explores the cultural history of embryology in Tibet, in culture, religion, art and literature, and what this reveals about its medicine and religion. Filling a significant gap in the literature this is the first in-depth exploration of Tibetan medical history in the English language. It reveals the prevalence of descriptions of the development of the human body - from conception to birth - found in all forms of Tibetan religious literature, as well as in medical texts and in art. By analysing stories of embryology, Frances Garrett explores questions of cultural transmission and adaptation: How did Tibetan writers adapt ideas inherited from India and China for their own purposes? What original views did they develop on the body, on gender, on creation, and on life itself? The transformations of embryological narratives over several centuries illuminate key turning points in Tibetan medical history, and its relationship with religious doctrine and practice. Embryology was a site for both religious and medical theorists to contemplate profound questions of being and becoming, where topics such as pharmacology and nosology were left to shape secular medicine. The author argues that, in terms of religion, stories of human development comment on embodiment, gender, socio-political hierarchy, religious ontology, and spiritual progress. Through the lens of embryology, this book examines how these concerns shift as Tibetan history moves through the formative 'renaissance' period of the twelfth through to the seventeenth centuries.

One out of every six patients in the United States is treated in a Catholic hospital that follows the policies of the U.S. Conference of Catholic Bishops. These policies prohibit abortion, sterilization, contraception, some treatments for miscarriage and gender confirmation, and other reproductive care, undermining hard-won patients’ rights to bodily autonomy and informed decision-making. Drawing on rich interviews with patients and providers, this book reveals both how the bishops’ directives operate and how people inside Catholic hospitals navigate the resulting restrictions on medical practice. In doing so, Bishops and Bodies fleshes out a vivid picture of how The Church’s stance on sex, reproduction, and “life” itself manifests in institutions that affect us all.

Male Reproductive Dysfunction: Pathophysiology and Treatment and Male Sexual Dysfunction: Pathophysiology and Treatment present the collective expertise of more than 60 international authorities in a single landmark text. From foundations in the anatomy of the male genital tract to the latest neuroimaging data, readers will appreciate the comprehensive information detailing the tremendous advances made in the delineation of sexual function and its disorders as well as the expert descriptions of practical and cost-effective medical, surgical, and psychological strategies for the treatment of all forms of male reproductive and sexual dysfunction.

Fetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease.

The use of IVM in assisted reproductive technology continues to increase around the world. The major benefit of IVM is that significant numbers of oocytes can be collected from ovaries without recourse to ovarian stimulation. This reduces the costs, time, and risks associated with conventional IVF. Although initially limited to women with polycystic ovary syndrome who were at higher risk of problems following ovarian stimulation, IVM is increasingly used in women with normal ovulatory menstrual cycles. This authoritative text covers the current scientific knowledge of oocyte development and the understanding behind the techniques involved in the clinical application of IVM in assisted reproductive technologies.
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Relevant to students, academics and practitioners across the globe, this original volume highlights contemporary issues associated with assisted reproduction and embryology and critically analyzes the law surrounding human reproduction in the light of case law and technological developments since the Human Fertilisation and Embryology Act (HFE Act) Act was passed in 1990. Tackling issues from an interdisciplinary perspective, the authors identify and evaluate areas that have provoked intense public and academic debate as well as those where further or renewed regulation is needed. Focusing primarily on the legal and ethical issues involved in regulating this area in the UK, which is at the forefront of developing legislation in this area, this book has international relevance as many countries have used the UK as a model for their own legislation. This text is suitable for a broad range of readers, including legal academics, law students and practitioners interested in the areas of medical/healthcare law and ethics, bioethics and moral philosophy, family law, sociology and reproductive medicine and genetics.

Infertility affects about five million individuals of childbearing age in the United States, yet infertility is a subject about which many people are reluctant to talk. This book discusses extensively many options available to individuals struggling with infertility. Infertility can result from a number of causes and affects men and women in equal numbers. Difficulty conceiving can take a heavy toll on couples both physically and psychologically and can lead to depression and marital discord. There are, however, many options available to those struggling with infertility for having a child. These include innovative medical procedures and powerful drugs as well as a variety of alternative treatment approaches, surrogacy, and adoption. A part of Greenwood's Health and Medical Issues Today series, this book provides an overview of these options and examines the many health, financial, and ethical decisions of each that must be considered when choosing one. Part I explores what causes infertility and the history and evolution of its treatment and then examines the options available today, detailing how they work, their success rates, and their risks. Additionally, it addresses controversial topics such as the legislation of assisted reproductive technologies and the regulation of fertility clinics. Part II delves into the many scientific, economic, and ethical debates that surround infertility treatment, presenting a clear and objective analysis of the issues. Part III provides a variety of useful supplementary materials, including case studies, a timeline of critical events, a glossary, and a directory of resources.

The transnational industry surrounding assisted reproductive technology and regenerative medicine is based on the unacknowledged labour of gamete providers, surrogates and research subjects, and benefits from low labour costs in 'enabling' sectors such as logistics and transport. This finding calls for a comprehensive analysis of how the contemporary intersection of neoliberal capitalism and the life sciences - in short, the bioeconomy - capitalises on the body and its (re)productive capacities. The Reproductive Body at Work uptakes this challenge as it explores the relations between value production, labour and the body in one particular realm of the global bioeconomy: the South African bioeconomy of 'egg donation'. It highlights different forms and dimensions of unacknowledged or precarious human labour that are constitutive for the procurement, brokering and circulation of oocytes as valuable resources. The analysis illustrates that the respective organisation of value and labour renegotiate what 'the' (re)productive body can do, which status and roles it is ascribed, which cultural and economic values it signifies and how it is experienced and enacted within a matrix of intersectional power relations. A theoretically profound contribution to the interdisciplinary debate on 'New materialism', The Reproductive Body at Work will appeal to students and researchers interested in fields such as gender studies, medical anthropology, cultural studies, sociology, political economy and science and technology studies.