In his memoir, One Heart-Embrace Life, author Dr. Charles Garbarino recounts his journey of recovery and rebirth following open-heart surgery. He reveals his innermost thoughts and feelings, from his reaction to receiving the unexpected news that he required cardiac bypass surgery to his subsequent depression and suicidal thoughts. He openly wonders why God gave him this burden to carry, but finally decides not to just survive his heart attack but to embrace life and live it to the fullest.

"One Heart" also recounts the experiences of others, from people who have had cardiac setbacks to those who have lost loved ones in catastrophic natural disasters, to our military troops who have given the ultimate sacrifice. This memoir is about life and its many components, focusing primarily on the heart, both emotionally and physically. Its underlying theme is to embrace life by understanding how to move ahead when challenges cross your path-whether you're facing the loss of a child or the discovery of a medical crisis.

"One Heart-Embrace Life" celebrates the many facets of life and the importance of a life well lived. It follows Dr. Garbarino through each step along the path to recovery and includes contributions from health and religious professionals.

The lessons are priceless. The journey is like no other. Get ready for a book that will change the way you look at things, forever.

All proceeds of "One Heart - Embrace Life" will benefit the American Heart Association.

This second volume of the highly practical and informative work continues the fine tradition of this exceptional series. It details the latest concepts and management techniques in oculofacial plastic surgery. It contains in-depth reviews of orbital disorders such as capillary hemangiomas and venolymphatic malformations, offering new strategies in diagnosis and management. Coverage also includes recent developments in the diagnosis and management of lacrimal disorders, including salivary gland transposition for severe dry eye and lacrimal stenosis. It will prove to be a valuable resource for both the comprehensive ophthalmologist as well as subspecialists with a particular interest in disorders of the orbit, eyelids, lacrimal system, and other facial structures.

Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.

The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer - screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.

Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.

The term "muscular dystrophy" (MD) describes a group of primary genetic disorders of muscle that often have a distinctive and recognizable clinical p- notype, accompanied by characteristic, but frequently not pathognomonic, pathological features. Research into the molecular basis of the MDs by a c- bination of positional cloning and candidate gene analysis has provided the basis for a reclassification of these disorders, with genetic and protein data augmenting traditional clinically based nomenclature. These findings have brought insights into the molecular pathogenesis of MD, with an increasing number of potential pathways involved in arriving at a dystrophic phenotype. Some common themes can be recognized, however, including the involvement of five members of the dystrophin-associated complex (dystrophin and four sarcoglycans) in different types of MD, and the involvement of two nuclear envelope proteins in producing an Emery-Dreifuss MD phenotype. Other d- ease-associated genes appear to cause MD in a completely unrelated way, such as the involvement of calpain 3 in a form of limb-girdle muscular dystrophy. Section 1 of Muscular Dystrophy: Methods and Protocols reviews tra- tional strategies used to identify MDs. Meantime, techniques developed as a result of the research strategies described previously have become an integral part of the management of many patients with MD and their families, and these techniques are addressed in Sections 2 (DNA-based tests) and 3 (p- tein-based analyses). The continued effort to translate this enhanced und- standing into a molecular cure or treatment for MD is reviewed in Section 4.

Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery is a comprehensive description of subdural monitoring of intracranial pressure (ICP) during neurosurgery. It offers thorough analysis of a comprehensive database consisting of measurements of ICP, cerebral perfusion pressure and other relevant physiological data from more than 1,800 patients subjected to intracranial surgery at Aarhus University Hospital. Features of anaesthesia, both inhalation and total intravenous, are discussed, and measures to reduce ICP are described. A majority of the patients had supratentorial tumours, but the database also includes patients with infratentorial tumours and patients with no intracranial space-occupying lesions. A chapter is reserved for discussion of the special features of children with cerebral tumours.

Combining years of clinical experience gathered by world-renowned experts, this is the only book to provide knee surgeons with a comprehensive guide to the many types of complications encountered in arthroscopic and meniscal surgery, the reconstruction of ligaments, patello-femoral surgery, fractures around the knee, and prosthetic knee arthroplasty. This unique volume, with over 400 line drawings and photographs, belongs on the shelf of every orthopaedic surgeon performing knee surgery.

This book highlights electromagnetic actuation (EMA) and sensing systems for a broad range of applications including targeted drug delivery, drug-release-rate control, catheterization, intravitreal needleless injections, wireless magnetic capsule endoscopy, and micromanipulations. It also reviews the state-of-the-art magnetic actuation and sensing technologies with remotely controlled targets used in biomedicine.

Being in the field of medicine and plastic surgery, I have realised just having knowledge and skills are not enough to be a successful plastic surgeon; you need to be a general surgeon, a doctor, and most importantly, a compassionate human being to be successful. You also need to be a good administrator, leader, businessman, and politician. You need to be a good teacher to continue the legacy. This is what I am striving to accomplish. My wish is that I will be able to follow my profession with dignity, sincerity, ethically and legally, and to teach the youngsters to do the same. This book is about a great discipline that is called plastic surgery. It is an intensely personal subject that causes a great deal of debate, often very emotional. More than any other branch of medicine, it is also surrounded by a dense, almost impenetrable fog of rumor, myths, and misconceptions. This book will educate you to understand what goes behind the scene. Not only that, but everything you need to know about the plastic and cosmetic surgery from choosing the right surgeon to avoiding disasters and getting the treatment you really need is here in the book.

In the past decade it has become increasingly clear that psoriatic disease, both of the skin and joints, can be a significant diagnostic and therapeutic challenge for the physician and a debilitating illness for the patient. At the same time, advances in genetics and immunology have increased our understanding of the pathophysiology of psoriasis and psoriatic arthritis. This text contains a comprehensive discussion by an international group of experts in psoriatic disease of the pathomechanisms, genetics, diagnosis, and treatment of psoriasis and psoriatic arthritis. The information is presented in parallel in order to emphasize the similarities and differences between these two diseases that so commonly occur together. We believe that this approach will make this text an important resource for all practitioners who treat patients with psoriasis and psoriatic arthritis.

Minimally invasive joint replacement has become one of the hottest topics in the orthopedic world. In the case of the knee, however, this concept has been widely misunderstood. All too frequently it is taken to mean keyhole surgery in which traditional components are implanted with a shorter surgical time. Such an approach in fact has few benefits and various possible dangers.

In this book, international experts discuss truly minimally invasive knee reconstruction techniques that involve tissue-sparing surgery and small implants and permit preservation of both the anterior and the posterior cruciate ligament. These techniques have the key advantage of respecting the physiological joint biomechanics. They also entail minimal removal of bone tissue from the tibia and only a small skin incision that avoids damage to the extensor apparatus. All of the most innovative techniques used in uni- and bicompartmental knee reconstruction are covered in detail, including computer-assisted procedures. Long-term results are reported, and pitfalls, highlighted. The reader will learn how, with careful selection of patients and rigorous surgical technique, compartmental reconstruction offers a valid alternative to total knee replacement.

This book details how medical and clinical teams that are comprehensive and interdisciplinary are able to effectively address the multiple difficulties that can result from an Acquired Brain Injury (ABI). Coverage describes the medical specialists that are integral members of a team and their specialized roles in assessment and treatment. It reviews some of the vital specialty areas that are often overlooked. The book also examines key discipline areas, such as occupational and speech/language therapies, and describes the main behavioral difficulties exhibited by individuals with ABI.

Management of Musculoskeletal Injuries in the Trauma Patient summarizes the most current concepts and clinical practices for the management of the patient with musculoskeletal traumatic injuries. The text covers optimal time frames for stabilization of orthopedic injuries and strategies to mitigate systemic injury while minimizing damage due to pelvic, spine and long bone trauma. The volume covers the gamut of traumatic axial and extremity injuries, including cervico-lumbar-thoracic spine injuries, spinal cord injuries, long bone fractures with special emphasis on the femoral shaft, pelvic and acetabular injuries, open fractures, mangled extremities, upper extremity injuries, combination and severe soft tissues injuries and periarticular fractures. These are discussed in the context of isolated injury and combined with orthopedic injuries of the brain, abdomen, chest and other musculoskeletal injuries. Written by internationally recognized experts, Management of Musculoskeletal Injuries in the Trauma Patient is a valuable resource for orthopedic surgeons.

The last five years have witnessed an increasing interest in the subject of transmyocardial laser revascularization (TMR) as illustrated by the number of abstracts presented at the meetings of the American Heart Association and the American College of Cardiology (Figure). The ideas and concepts associated with this particular method of myocardial revascularization have changed dramatically over even this short period of time. The original premise of "de-evolving" mammalian hearts to recreate a reptilian-like myocardial circulation by making multiple channels through the myocardium has been almost (but perhaps not quite) completely dismissed. Now, the most popular notion is that there is an angiogenic response to myocardial channel making. It is this development of new blood vessels that is thought to be responsible for the apparent improvements in symptoms and blood flow. Along the way, the idea that a channel could stay open and allow blood to flow directly from the ventricular chamber has found little support. Rather than directly explore all of these issues and merely duplicate previously published articles, our aim was to take a novel approach: that is, to step back from these arguments and provide perspective from the vantage point of distance. In the case of trans myocardial revascularization, distance comes both in terms of history and in terms of methodology and knowledge from other fields of research. Historically, innovative methods of myocardial revascularization are by no means uncommon. The first two chapters deal with this historical' perspective.

It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, and one of the first to be successfully repaired by congenital heart surgeons. Although "fixed", patients born with tetralogy of Fallot cannot be considered "cured". Improving survival and quality of life for this ever-increasing adult population will continue to challenge the current and future generations of cardiologists. Adult patients with tetralogy of Fallot should be seen by a cardiologist specializing in the care of adults with congenital heart disease, to be monitored for late complications. They need to be checked regularly for any subsequent complications or disturbances of heart rhythm. This monograph is intended as both an introduction to the subject and a timely, comprehensive review, and will be welcomed by adult cardiologists, pediatric cardiologists, internists, surgeons, obstetricians, and intensivists who wish to learn about the most recent discoveries and advances concerning tetralogy of Fallot in adults. It will also be of interest to advanced undergraduates wanting to learn more about the subject.

Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

This book represents the first comprehensive textbook devoted to the standard of care, current guidelines and innovations in the field of mesenteric vascular disease. The book reviews imaging modalities, diagnostic work up, physiologic tests, traditional open surgical techniques and novel endovascular approaches. Technical aspects of both open surgical and endovascular techniques are provided by experts in the field, with illustrations and photographs of key steps for each type of procedure. Results of epidemiologic studies and national databases are summarized, as well as large institutional experiences. An evidence-based approach is used for recommendations regarding best therapies. Diagnostic approaches including imaging and novel physiologic tests, including gastric tonometry and oxygen light spectroscopy are covered. Mesenteric Vascular Disease: Current Therapy will serve as a very useful resource for clinicians, surgeons, interventionalists, gastroenterologists and researchers dealing with and interested in mesenteric vascular diseases.

A highly clinical, practical book on carotid diseases, which focuses on management options. For each management question an expert from Europe and from the US offer their views, and for particularly controversial topics more than one author has been invited to comment. Conclusions or management options are summarised in a box at the conclusion of each topic, which allows easy referral. The book is divided up into three main parts, covering pre-operative work-up, operative aspects and post-operative care. Chapters include evidence-based recommendations and experts personal opinions and reflect on-going clinical debate.Practical, focussed and clinically relevant. Highlights the most controversial issues with expert opinions on each.Management options summarised for easy referral. An up-to-date summary on the challenging area of carotid disease.Reflects on-going clinical practice. Includes evidence-based information.Covers many practical and controversial issues that are not mentioned in the mainstream textbooks. Includes expert input from 60 experienced clinicians from the US and Europe.Reflects queries and problems faced by surgeons in their day-to-day work.

This practical and instructional guidebook, written by international experts in anterior cruciate ligament (ACL) reconstruction, covers all challenging aspects of ACL rupture in the acute and chronic setting. It covers the latest, spectacular anatomical findings, treatment of partial ACL tears, various techniques for single- and double-bundle ACL reconstruction, and complex ACL revision surgery. Important surgical steps are clearly described with the help of instructive, high-quality photographs. Important tips, tricks, and pitfalls are highlighted and intra- and postoperative complications, rehabilitation, and prevention of re- rupture are discussed. All authors are prominent and experienced ACL surgeons.

Metabolic bone degeneration (osteoporosis) affects millions of people--primarily postmenopausal women--and is directly responsible for debilitating hip, vertebral, and limb fractures in the elderly. Incorporating advances made within just the past five years, The Osteoporotic Syndrome: Detection, Prevention, and Treatment serves as an up-to-date, practical guide to the major clinical aspects of osteoporosis. The text is liberally illustrated with detailed figures.
As a resource for the clinician dealing with metabolic bone degeneration, this book represents an excellent source of information on the diagnosis and day-to-day management of osteoporosis.
Topics covered include
* Therapy with Vitamin D metabolites, sodium fluoride, thiazides, and isoflavones
* Biochemical markers of bone turnover
* Calcium, Vitamin D, and bone metabolism
* Estrogens and tissue selective estrogens for prevention and treatment of osteoporosis
* The effects of osteoporosis on orthopaedic surgery
* The therapy of glucocorticoid bone disease
* Effects of aging on bone structure and metabolism
* Management of osteoporotic patients in our health care delivery system
* The genetics of osteoporosis
* Bisphosphonate therapy for osteoporosis
* Calcitonin
* Bone mass measurement techniques in clinical practice
* Osteoporosis and the bone biopsy

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.
* The revised fourth edition contains approximately 50% new material
* Includes information on all the latest drugs