• Contributors are internationally known experts • Richly illustrated • Focuses on the differences of diagnostic methods between Japan and other countries by using endoscopic and pathologic pictures • For the first time, the Japanese progress in the field is published in English and made accessible to researchers worldwide

In the present book with the title "Modern Trends in THA Bearings - Material and Clinical Performance" a notable editor and many worldwide renown experts are contributing to this topic. The surgeons are describing their long-term experience regarding the behaviour and clinical performance of primary and revision hip arthroplasty. Material aspects, indications, surgical techniques as well as problems and recommendations for different bearing couples are extensively discussed. The clinical performance of ceramic bearings is highlighted as well as the recommendations for safe implantation. Altogether, for the experienced surgeon as well as for the resident, this book gives a valuable overview on the state-of-the-art techniques and bearing materials used in hip arthroplasty.

In "Revision Sinus Surgery" the world’s most prominent rhinologists illustrate their experience in diagnosing and managing recurrent sinus disease and skull base lesions. Starting with preoperative planning and medical management, these challenging cases are well-illustrated with the relevant surgical techniques. This invaluable resource is designed to prevent complications and improve the outcomes of revision sinus surgeries. Both practicing and in-training otolaryngologists can use this comprehensive volume as an all-in-one source for the evaluation and management of recurrent sinus disease and skull base pathology.

Practical Procedures in Aesthetic Dentistry presents a comprehensive collection of videos demonstrating clinical techniques in aesthetic and restorative dentistry, and is accompanied by a handbook summarising the key points of each procedure. * Interactive website hosting over nine hours of video * Accompanying illustrated handbook summarising key points * Expert teaching across a comprehensive range of aesthetic and restorative procedures * International team of contributors with clinical and academic expertise

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.

Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration.

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Access the information you need to confidently diagnose and treat musculoskeletal disorders at a glance! With a "5-books-in-1" approach, this essential clinical reference provides up-to-date diagnostic and therapeutic information on over 200 orthopedic conditions in a bulleted, quick-reference format ideal for both students and practitioners. Content is written entirely by orthopedic physical therapists and is logically organized to promote accurate, efficient differential diagnosis and intervention. '5-books-in-1' format combines essential content on foundational knowledge, clinical reasoning, orthopedic pathologies, common clinical questions, and pharmacology all in one place for fast, efficient reference. UNIQUE: Expert insight and decision-making strategies for the rehabilitation of musculoskeletal pathologies help you apply sound clinical reasoning to determine the needs of patients with musculoskeletal disorders. UNIQUE: Succinct, bulleted text organizes information consistently for easy access. Clinician-oriented profiles cover 200 orthopedic pathologies with considerations specific to your needs in orthopedic rehabilitation practice. 51 drug class monographs detail indications, dosages, contraindications and physical therapy implications to help you better understand drug interactions and more effectively manage patients.

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

'A SUPERB ACHIEVEMENT' IAN MCEWAN * * * * * What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut through the stuff that creates thought, feeling and reason? How do you live with the consequences when it all goes wrong? DO NO HARM offers an unforgettable insight into the highs and lows of a life dedicated to operating on the human brain, in all its exquisite complexity. With astonishing candour and compassion, Henry Marsh reveals the exhilarating drama of surgery, the chaos and confusion of a busy modern hospital, and above all the need for hope when faced with life's most agonising decisions. * * * * * Winner: PEN Ackerley Prize South Bank Sky Arts Award for Literature Shortlisted: Costa Biography Award Duff Cooper Prize Wellcome Book Prize Guardian First Book Award Slightly Foxed Best First Biography Prize Longlisted: Samuel Johnson Prize for Non-Fiction

This book is a one-stop guide to managing acute orthopedic injuries. Unlike other handbooks, this reference provides a comprehensive, yet concise, set of diagnostic and management tools to help readers deliver optimal, evidence-based, and efficient patient care. Additional focus on physical exam techniques, emergency room orthopedic procedures, and on-field athletic management strategies empowers readers with real tips and tricks used by orthopedic surgeons at top-tier institutions. This guide is a must have for emergency medicine providers, orthopedic surgeons, and other clinicians, trainees, and students caring for adult or pediatric patients in the emergency setting.

Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects uses a metabolic and nutritional theme to explain the complex interrelationships between obesity and metabolic profiles before and after bariatric surgery. The book is sectioned into seven distinct areas, Features of Obesity, Surgical Procedures, Nutritional Aspects, Metabolic Aspects, Diabetes, Insulin Resistance and Glucose Control, Cardiovascular and Physiological Effects, and Psychological and Behavioral Effects. Included is coverage on the various types of bariatric surgery, including Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, biliopancreatic diversion, and jejunoileal bypass, as well as the variations upon these procedures.

This book, which describes in detail the most common procedures employed in inguinal hernia surgery, is exceptional in reflecting fully the most recent advances, as well as the most established techniques, in knowledge and practice. The role of recently developed and emerging technologies, including robotics, minimally invasive surgery, and biological meshes, is clearly explained, highlighting useful tips and tricks. The descriptions of traditional procedures, such as the Lichtenstein repair, are brought fully up to date and take into account the novel perceptions that professionals have of them, for example regarding the important role of nurses. The reader will also find guidance on established and new treatments for specific pain conditions, including postoperative chronic pain, the pubic inguinal pain syndrome, and obscure groin pain in women. The need for such an update on inguinal hernia surgery became clear at the 1st World Conference on Abdominal Wall Hernia Surgery, which highlighted the huge differences in the approaches adopted by scientists around the world and was chaired by the editor of this book. Inguinal Hernia Surgery will be a useful tool for all health care practitioners involved in hernia surgery.

The purpose of this book is to contribute to basic and clinical medical research on cochlear implants for inner ear malformation and cochlear nerve deficiency. Cochlear implantation for children is performed worldwide, and the outcomes concerning speech and hearing acquisition are epoch-making. However, there are some difficulties associated with applying this operative treatment to patients who have complicated inner ear malformations or cochlear nerve deficiencies that have slowed the development of their speech, hearing, and/or sense of balance. The first part of the book outlines the fundamental aspects of inner ear maldevelopment to facilitate readers' understanding of cochlear implantation from the point of view of embryology, morphology, and genetics. In turn, the second part describes current clinical cases and presents successful clinical reports. The book offers a primary resource for otolaryngologists, neurologists, and pediatricians with an interest in this field.

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

This detailed second edition provides key updates on well-established methods as well as coverage of recently emerging sophisticated techniques and methods that are essential for an in-depth and state-of-the-art understanding of skeletal development and homeostasis and the pathological mechanisms that cause skeletal degeneration. The first half of the book examines cell and molecular biological aspects of osteoarthritis and osteoporosis, while the remainder of the collection focuses on in vivo models of skeletal tissue injury, degeneration, and repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Osteoporosis and Osteoarthritis, Second Edition aims to assist investigators concerned with research topics broadly related to osteoporosis, osteoarthritis, intervertebral disc degeneration, as well as other musculoskeletal disorders.

Experimental Methods in Orthopaedic Biomechanics is the first book in the field that focuses on the practicalities of performing a large variety of in-vitro laboratory experiments. Explanations are thorough, informative, and feature standard lab equipment to enable biomedical engineers to advance from a 'trial and error' approach to an efficient system recommended by experienced leaders. This is an ideal tool for biomedical engineers or biomechanics professors in their teaching, as well as for those studying and carrying out lab assignments and projects in the field. The experienced authors have established a standard that researchers can test against in order to explain the strengths and weaknesses of testing approaches.

This book will be a 'how to' guide for medical students interested in pursuing a career in academic surgery. It will discuss personal traits and rationale for going into academic surgery. It will review accomplishments as a medical student that are key components of beginning an academic career and highlight what makes a student competitive for a surgical program. Sections will be devoted to mentorship, research experience and personal experiences that lead to success. The editors will also focus on gender and work-life balance issues that often are perceived as barriers to a career in academic surgery. It will also provide key dates and sample application information for students to use as templates.

This first reference to comprehensively address both the medical and surgical management of diseases affecting the colon, this source spans the wide array of colorectal disorders including rectal prolapse, irritable bowel syndrome, benign and malignant colonic tumors, fissures and ulcers, and Crohn's colitis, among other ailments. With chapters by world leaders in the field, this guide analyzes diagnostic and imaging techniques for disease evaluation and management including advances in colonoscopy, radiology, and surgery.

Material-Tissue Interfacial Phenomena: Contributions from Dental and Craniofacial Reconstructions explores the material/tissue interfacial phenomena using dental and craniofacial reconstructions as a model system. As the mouth is a particularly caustic environment, the synthetic and/or bio-enabled materials used to repair damaged tissues and restore form, function, and esthetics to oral structures must resist a variety of physical, chemical, and mechanical challenges. These challenges are magnified at the interface between dissimilar structures such as the tooth/material interface. Interfacial reactions at the atomic, molecular, and nano-scales initiate the failure of materials used to repair, restore, and reconstruct dental and craniofacial tissues. Understanding the phenomena that lead to failure at the interface between dissimilar structures, such as synthetic materials and biologic tissues, is confounded by a variety of factors that are thoroughly discussed in this comprehensive book.

The 4th year of medical school represents an important transition with new goals and expectations. Matching into orthopedic surgery residency is increasingly competitive. Performing well on orthopedic surgery rotations during the 4th year of medical school is critical for match success. The goal of this guide book is to help students ace their orthopedic rotations. Orthopedic Surgery Rotation focuses on practical tips for success from optimal study resources, key technical skills, and strategies for being a standout orthopedic team player. Each chapter is written by current orthopedic residents, who not only know from personal experience on how to excel but also are actively involved in evaluating the performance of 4th year medical students. < This book will serve as tool to propel students to the next level and help them start their journey as orthopedists on the right foot.

This volume features up-to-date protocols for the isolation, preservation, and validation of various cell sources comprising large and small animal models, examining the impact of cell transplantation on acute and chronic liver diseases. Hepatocyte Transplantation: Methods and Protocols guides readers through laboratory protocols for the generation of humanized livers for the assessment of biological actions in vivo and techniques to monitor cell engraftment after cell transplantation in vivo are described and procedures for computational analyses of hepatocyte transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hepatocyte Transplantation: Methods and Protocols is an essential resource for researchers and clinicians to assess the biological as well as the therapeutic potential of hepatocyte transplantation.

Vascular surgery has experienced remarkable growth and diversification in the last decade, especially with its embracing the disruptive endovascular technological revolution. Vascular surgeons remain the only group of specialists capable of total treatment of patients with vascular disease, providing medical, minimally invasive, and surgical therapy. Although vascular surgeons practice in all areas of the world, practice patterns in different areas naturally have both similarities and differences that reflect both regional patterns of disease, genetic characteristics of local peoples, cultural preferences for treatment, local political and economic situations, different access to resources and devices, as well as different training paradigms. Thus, the practice of vascular surgery has diversified and evolved in parallel in many areas, converging and diverging in many ways. Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.

This book is written for the users and designers of joint replacements. In its second extended edition it conveys to the reader the knowledge accumulated by the authors during their forty year effort on the development of replacement devices for the lower limb for the purpose of aiding the reader in their design and evaluation of joint replacement devices. The early chapters describe the engineering, scientific and medical principles needed for replacement joint evaluation. One must understand the nature and performance of the materials involved and their characteristics in vivo, i.e. the response of the body to implant materials. It is also essential to understand the response of the implants to applied loading and motion, particularly in the hostile physiological environment. A chapter describes the design methodology now required for joint replacement in the USA and EU countries. The remaining chapters provide a history of joint replacement, an evaluation of earlier and current devices and sample case histories of some of the authors’ devices. The present second edition includes various additional case reports as well as a new chapter devoted to the shoulder. Drs. Buechel, an orthopaedic surgeon, and Pappas, a professor of Mechanical Engineering, are the designers of several successful joint replacement systems. The most well-known of these is the pioneering LCS knee replacement.