While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene?ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this book reviews current and upcoming approaches to early detection. Imaging strategies, including mammography, breast ultrasound, MRI, and PET imaging are reviewed. The potential for molecular tumor targeting to detect disease prior to the formation of a mass visible by anatomic imaging is presented.

The temporal bone is located at the lower sides of the skull and directly underneath the temple. Part of the Clinico Radiological Series, the new edition of this book reviews current techniques in imaging of the temporal bone and associated disorders. Beginning with an introduction to normal anatomy and the various imaging modalities, the following sections discuss various disorders including congenital anomalies and infections of the external and middle ear; inner ear, internal auditory canal and cochlear implant, and tumours. The final sections explore the clinico-radiological approach to hearing loss, vertigo, tinnitus and facial nerve palsy, concluding with an examination section. The second edition has been fully revised to cover the latest advances in the field. Each topic is presented in a step by step format and illustrative cases and reporting templates are provided for each section. Radiological images and tables enhance learning. Key points Comprehensive review of imaging techniques for the temporal bone Fully revised, second edition covering latest advances in the field Each section includes illustrative cases and reporting templates Previous edition (9789385891908) published in 2016

This book will provide both an evidence base and practical recommendations for the treatment of patients with congenital heart disease. It will be a resource to all health care providers, including pediatric cardiologists, pediatric intensivists, pediatric heart surgeons, fetal specialists, maternal fetal medicine specialists, neonatologists, nurses, advanced practice nurses, in addition to trainees in the field. It will summarize world knowledge on the topic of heart failure in patients with congenital heart disease. It will provide an in depth analysis of the current methods of diagnosis and treatment of heart failure. Now that surgical results are at record success rates, more patients with congenital heart disease are surviving, and thus at risk for sequelae from their disease, including heart failure. It will provide evidence based and practical recommendations to the practitioner for the management of heart failure signs and symptoms.

This comprehensive and practical book fills the current knowledge gap about the incidence and characteristics of seizures in all kinds of cerebrovascular disorders. Chapters are divided according to the nature of cerebrovascular diseases and highlight incidence, early versus late onset seizure types, pathophysiology, electro-clinical manifestations, treatment and prognosis. Authored by leaders in the field of epilepsy and stroke, Seizures in Cerebrovascular Disorders is an excellent resource for the daily management of patients suffering from this disease overlap.

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Perioperative care is the care that is given before and after surgery. This textbook is a complete guide to the anaesthetic and critical care management of patients undergoing complex surgeries in all organ systems of the body. Topics cover all age groups - neonates, children, and adults. Divided into 11 sections, the book begins with a general overview of critical care in the perioperative period discussing airway management, pain, fluid and electrolyte therapy, shock, arterial blood gas analysis, respiratory failure and mechanical ventilation, and thromboembolism. The following sections cover surgeries in different organ systems and patient groups - cardiothoracic and vascular, neurosciences, paediatrics, obstetrics and gynaecology, gastrointestinal, genitourinary, orthopaedics, head and neck, and transplantation. The final section explains selected miscellaneous topics including nutrition, haemodynamic monitoring, echocardiography, renal replacement therapy, and antibiotics. Compiling 700 pages, the comprehensive text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to perioperative critical care in neonates, children and adults Covers complex surgeries in all organ systems Includes discussion on imaging, airway management, and ventilation Highly illustrated with clinical photographs, diagrams and tables

Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.

This book is an organized approach to understanding bone growth and disease. It integrates anatomic and radiologic knowledge of enchondral and membranous bone growth and emphasizes the similarities of the physis and acrophysis in development. The artwork, jointly produced by artist and author, illustrates the concepts described. The identification of abnormality is aided by the explanations of the causes in terms of pattern recognition.

A much revised and redesigned edition of Adams's classic textbook on fractures. The trusted Outline textbooks, now celebrating their 50th year in print, are well known for being clear, comprehensive and concise and will appeal to undergraduate, postgraduate and trainee surgeon alike. New edition of highly praised book with an established reputation Well known for its clear writing style and logical classification of fractures Basics of treatment are summarised in a useful appendix for quick reference and revision Provides up-to-date surgical therapies as well as conservative treatment options New author line-up Clear new page format, using two-colour design Extended artwork programme, now including two-colour line artworks, new radiographs, MRI and CT scans Enhanced anatomical classification system Advances in cell biology and molecular genetics New chapter on osteoporosis, including fracture treatment in the elderly

Indispensable for both the trainee and experienced professional, this is the only truly comprehensive account of the major role of the neurosurgeon in the diagnosis and treatment of chronic pain. The elite panel of contributors were chosen due to their expertise and international reputations. The result of their achievement covers the whole spectrum from criteria for patient selection and the details of operative techniques, to the risks, complications, and expected outcomes for a wide variety of anatomic, ablative, and augmentative neurosurgical procedures in treating chronic, intractable pain. The neurosurgeon will find here chapters on the latest neuroaugmentative advances utilizing electrical stimulation and implantable drug infusion systems as well as a useful section providing algorithms and guidelines for the evaluation and treatment of specific pain syndromes. Over 100 photographs and exquisite line drawings - many specifically commissioned for this book - enhance the text. Invaluable for acquiring the critical judgement and clinical skills necessary to apply the procedures involved.

This new reference covers the top 100 pearls in cutaneous oncologic, nail and cosmetic dermatologic surgery, giving you at-a-glance access to some of the best know-how in the field. Organized in a consistent format, and illustrated with full color photographs and explanatory line drawings, this is the perfect tool to help you improve the level of care you offer your patients. Whether you're new to the field or you've been practicing dermatologic surgery for years, you'll consider this book one of your most valuable resources. Fills a gap in the field by bringing together material that is rarely gathered in one book. Includes expert hints and tips on avoiding common pitfalls in cosmetic and dermatologic surgery. Illustrates each pearl with line drawings and photographs to put it into clinical context.

Even the brightest lights grow dim if they are not attended, and the great old torch-bearers and their works needs refreshment. After Nicaise all the Europeans, except the English speaking people, had new editions and translations of Guy's Major Surgery. With this translation of Nicaise's edition, all of the eight seminal treatises by the surgeons who brought surgery anew into Europe now are available to the English-Reader. The long discursive Introductions and footnotes by Nicaise and Joubert, and footnotes and explanatory insertions by this translator supplement Guy's text with a fine history of French surgery. Indeed, as Nicaise wrote in the historical Introduction to his edition of Pierre Franco, if we were to combine the introductions in his editions of Henri de Mondeville, Pierre Franco, and Guy de Chauliac with Malgaigne's Introduction to his edition of Ambroise Pare, we will have a complete history of European Surgery before the modern era. Guy's era was that of the Great Plague, and his book was written after its first invasion. His respectful attitude toward his colleagues and his suave gentility secured him as an officer of the Church, and as a Surgeon for The Popes at Avignon.

This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

For the thousands of people affected by severe obesity, the decision to undergo weight loss surgery can be a matter of life and death. But it is not a simple procedure. That's why, for many, the decision does not come easily. To help you make the best possible choice, a dynamic team of experts have come together to share their experience, knowledge, and findings about these procedures. Merle Cantor Goldberg is one of this country's leading psychotherapists specializing in eating disorders; Drs. Cowan and Marcus have helped develop many of the techniques used in bariatric surgery, and have also taught these procedures to hundreds of other surgeons. "Weight Loss Surgery begins by asking important questions that must be considered before any decision is made. It then presents a comprehensive overview of pre-op visits, the various weight loss surgeries available, and the post-op recovery period, examining both the psychological and the physical impacts of the surgery. Weight loss surgery is not a minor procedure, but when appropriate, it can save lives. This thoughtful book offers the information you need to make the decision that's right for you.

This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful."

In this book, world-renowned experts describe the latest advances in minimally invasive gynecologic surgery and explain why endoscopy is of key importance in so many conditions. Hysteroscopic instrumentation is described and the application of hysteroscopic techniques in patients with polyps, fibroids, malformations and infertility is explained and evaluated. Individual chapters are devoted to the current minimally invasive treatment of endometriosis, endometrial polyps and adenomyosis. The role of laparoscopy in gynecologic oncology and the laparoscopic approach to hysterectomy are fully discussed. Various other applications of laparoscopy are considered, with coverage of techniques including traditional straight stick laparoscopy, barbed suture and robotic and single port surgery. Neurophysiology and the use of laparoscopic therapy to restore vital function are discussed and complications of laparoscopic surgery are also addressed.