This book is the first to provide a thorough overview of the experience of pancreas transplantation in Asian countries, including in particular Korea, Taiwan, and Japan. Recent trends are identified and attention drawn to differences in comparison with the United States and Europe. Such differences relate, for example, to the history of pancreas transplantation, the operative procedure, and the organ-sharing system. In addition, the insulin-secreting ability of pancreatic islet cells is thought to vary depending on race. Beyond these aspects, the coverage also encompasses ABO-incompatible living donor pancreas transplantation, which is very rarely performed elsewhere in the world. By introducing the number, technique, and outcomes of pancreas transplantation in Asian countries, the book will hopefully further stimulate the pancreas transplantation program in this region and beyond. It will be of value for all medical professionals in the field and will be informative for diabetic patients receiving insulin treatment in Asia.

Spinal surgery is a unique area in the process of continuous development. New skills are applied daily in this delicate field by the spinal surgeon: this professional can be either an orthopaedic surgeon or a neurosurgeon dedicated to the treatment of spinal diseases. This book offers a comprehensive approach and reviews all of the possible errors encountered by spinal surgeons in the clinical practice. It is mainly directed towards young surgeons approaching spinal surgery and also to experienced surgeons with regards to complications related to the latest technologies in the spinal field. This approach of treating and understanding problems in cervical spine surgery is unique and will guide the reader towards an improved level of attention regarding pitfalls in cervical spine surgery, therefore fostering the ability of preventing major complications and medicolegal consequences.

This book covers the most important topics in the field of personalized orthopedics. It starts with the 3D geometry of the bones, focusing on the problem of reverse engineering of the bones. It also shows the application of a 3D geometric model of bone for the design of personalized implants and prostheses. This book covers the application of additive technologies in personalized orthopedics as well as prediction, simulation and optimization in personalized orthopedics. Its content provides the necessary knowledge for the transition from classical to personalized orthopedics. The authors present an original method for reverse bone engineering-the Method of Anatomical Features (MAF). This method is unique as it enables the reconstruction of the original geometry and topology of the bone, even when only data on its part are available. The application of this method is shown on the examples of human long bones, mandible and hip bone reconstruction. This book contains a review of several real cases of personalized implants. It gives several examples of prostheses for the design of which a 3D model of bones was used, as well as other patient data on the basis of which personalized prostheses were designed.

The aim of this open access book is to provide a unique, timely, critical and comprehensive compilation of more than 30 years of robust international experimental and clinical research related to the basic science and therapeutic application of water-filtered infrared-A (wIRA) and hyperthermia in oncology, psychiatry (depression), musculoskeletal disorders, dermatology, infectiology, and surgery. This is an internationally absolutely unique attempt which publication is timely and of great interest in medical as well as in natural sciences. The aim is to enhance communication and advance the use of heat therapy for patient benefit, and to generate an environment in which anyone with an interest in hyperthermia can discuss, collaborate, network, and share events and resources. Productive dialogue and discussion among scientists and practitioners on issues relating to hyperthermia therapy is essential, especially relating to thermal transmission by water-filtered infrared-A (wIRA). The specificity and advantage of this technology is its tolerance by tissue, and its penetration of up to 3 cm allows the delivery of high heat dosages that are relevant across multiple clinical indications. Currently, wIRA is being applied in Austria, Germany, Portugal, Switzerland, The Netherlands, UK and the USA. The authors' hope is that its use will increase in these countries, and also expand into others. This book will be an invaluable tool for oncologists, surgeons, dermatologists as well as physiotherapists.

The term "minimally invasive spinal surgery" was coined in early 1990 following pub- cation of the first edition of this text entitled Arthroscopic Microdiscectomy: Minimal Intervention in Spinal Surgery, and subsequent establishment of the International Society for Minimal Intervention in Spinal Surgery (ISMISS) under the auspices of the International Society of Orthopaedic Surgery and Traumatology (SICOT) in April l990. The orthopedic and neurological surgeons who participated in lectures and hands-on wo- shops both in Philadelphia and abroad have witnessed the evolution of minimally invasive spinal surgery from blind nucleotomy to endoscopic fragmentectomy, decompression of l- eral recess stenosis, foraminoplasty, and spinal stabilization. In Arthroscopic and Endoscopic Spinal Surgery: Text and Atlas, Second Edition, experts describe and illustrate various techniques and approaches that are currently used in this field. In addition, the ongoing research for the betterment of spine care via minimally invasive approaches is briefly reviewed. I would like to express my sincere appreciation to so many of my colleagues who s- ported my efforts in the field of minimally invasive spinal surgery throughout the years. Many of them participated in our teaching symposiums and have provided valuable cont- butions to this text.

Atlas of Human Cranial Macromorphoscopic Traits synthesizes macromorphoscopic traits and their analysis in an accessible manner, providing detailed descriptions and examples of the various character state manifestations intended for use in classrooms, laboratories, and in the field. The volume begins with an outline of the macromorphoscopic dataset, its history, recent modifications to the historical approach, and recent technological and analytical advances. Additional sections cover Nomenclature, Gross Anatomy, Function, Methodology, Line Drawings, Detailed Definitions, Multiple High-resolution Photographs, and Population Variation Data from the Macromorphoscopic Databank (MaMD). The volume concludes with a chapter outlining the statistical analysis of macromorphoscopic data and a summary of the computer programs and reference databases available to forensic anthropologists for the analysis of these data.

Dr. Jay A. Goldstein 's Betrayal by the Brain can be a daunting treatise to the layperson as well as a challenge for the physician who is not versed in neurology, psychiatry, immunology, and endocrinology. Here, in A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain: A Guide for Patients and Their Physicians, Author Katie Courmel, a longtime sufferer of chronic fatigue syndrome and fibromyalgia, presents in layperson 's terms the salient points of the book to lead readers to an understanding of Dr. Goldstein 's theory and methods of treatment. This guide provides CFS and FMS patients with an understanding of how their brains should function as opposed to how they are now dysfunctioning. It explains the proper role and function of each brain structure and neural assembly and the neurochemicals believed to be implicated in CFS and fibromyalgia along with the dysfunctions found in CFS/FMS patients. These dysfunctions, as a whole, form the basis of Dr. Goldstein 's unified theory behind the possible causes of CFS and FMS. Patients involved in or contemplating Dr. Goldstein 's treatment can use A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain to gain an explanation of the process from a firsthand perspective and can follow along to learn why they are given particular drugs and what response Dr. Goldstein hopes to elicit from their bodies. This understanding gives patients a sense of control and helps them weather the ups and downs their bodies experience as a normal response to the treatment. The strength of A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain lies in its ability to simplify without sacrificing the body of information that one must understand to make sense of the multitude of seemingly unrelated manifestations of these diseases of the brain. A thorough understanding will allow sufferers of CFS/FMS to approach Dr. Goldstein 's treatment method with an open mind and improve their chances for success. Specific questions answered for readers include: how safe is this protocol? should I go alone or take a companion? what should I expect during my initial consultation? what are the effects of so many drugs? why doesn t the same drug work for everyone? if my treatment is successful, how long will it last? what happens when I leave Dr. Goldstein 's care? A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain prepares readers for a unique, sometimes scary, often perplexing, hopefully miraculous, leap-of-faith experience. It helps patients deal with the very natural sense of uneasiness they may be feeling and helps them understand, in layperson 's terms, what Dr. Goldstein 's protocol can accomplish and how it can be so successful.

This volume examines one health issue -- breast implants -- across a series of contexts often thought to be separate -- media coverage, doctor-patient interaction, doctor-doctor professional communication, support group dialogues, public relations campaigns, and more. In so doing, it provides a narrative of how communication shapes the individual perceptions of health, government, and social policy concerning health care.
At the core of the silicone breast implant controversy is the need for people to act amid uncertainty about the health risks involved. This need to weigh action in the midst of uncertain risk characterizes a large number of health issues. The attempts of patients, physicians, drug manufacturers, and others to seek and provide both information and influence makes communication central to these issues. Consequently, the questions explored in this volume will interest a diverse group of readers. This audience includes plastic surgeons in particular, physicians in general, and anyone involved with women's health issues. As the medical profession struggles with its identity amid changes in public attitudes, government regulations, and medical practices, this volume's findings concerning media portrayals of doctors and medical devices become even more important.
Finally, this study reveals how interrelated public information and private decisions are, and how closely media and interpersonal relationships fit. Tracing one medical issue across interpersonal, organizational, public relations, and mediated forums has clearly demonstrated the multiple ways those communication channels overlap and inform one another.

Few clinical disciplines have been transformed so dramatically by advancements in science and technology as gastrointestinal surgery. To begin with, modern ph- macology has virtually eliminated some kinds of surgery altogether. If one were to take a peek at a typical operating room schedule in a busy hospital of the 1960s, gastrectomies of one kind or another would have constituted a large block of the major surgeries. The advent of effective H2-histamine receptor antagonists and, more + + recently, the H, K -ATPase (proton pump) inhibitors led to a precipitous decline in those procedures such that they are rarely performed today. Exciting new approaches to treating inflammatory bowel diseases and their complications-such as fistulas- with anticytokine therapy may one day have a similarly profound effect on surgery for this condition as well. Beyond pharmaceutics, advances in imaging techniques have greatly facilitated the identification and characterization of pathology in the gastrointestinal tract in a way that would have been unimaginable only a few years ago. Just to visualize the pancreas in some way was a horrendous task until abdominal ultrasound, magnetic resonance imaging, or computer tomography made it simple. The fact that the gut is a hollow organ that can be accessed through the mouth, anus, or even through the wall of the abdomen has been fully exploited with fiberoptic endoscopes that can bend around corners with ease and permit surgery to be conducted through them.

Minimally Invasive Surgery of the Foot and Ankle represents a novel approach to treatment of orthopedic problems in the foot and ankle. The gradual change of philosophy in the management of foot and ankle surgery means that patients require a less invasive approach to surgery and a consequent improvement in recovery time. Describing the techniques and, importantly, the indications for minimally invasive procedures for the management of foot and ankle ailments, this book will explain the management of various conditions and how they can be approached using minimally invasive techniques. However, rather than only concentrating on minimally invasive surgery of the foot and ankle, the authors will be examining the options open to surgeons operating in this area both open surgical and arthroscopic and explaining the benefits of each. Extensive radiographs, diagrams, and intra-operative pictures will illustrate the procedures described.

This book will incorporate a multimodality approach toward inflammatory bowel diseases. Up to date imaging methodologies will be described along with their strengths and weaknesses that will help in providing a rational diagnostic strategy for clinical, surgical and support teams working with these patients. Advances in medical and surgical treatment would be detailed and these would be useful to readers and professionals keen to implement these techniques in their own clinical practice.

Thisisthefirstvolumeinthe CerelJral Cortexseriesdevotedtomathematicalmodels ofthecortex. Itwasmotivatedbytherealizationthatcomputationalmodelsof individualneuronsandensemblesofneuronsareincreasinglyusedinresearchon corticalorganizationandfunction. Thisis,inpart,becauseofthenowubiquitous presenceofpowerfulandaffordablecomputers. Suitablemachineswereformerly rareinresearchlaboratoriesandrequiredsubstantialprogrammingexpertisetobe usedinconstructingandusingneuronalmodels. However,computersarenow routinelyusedinallareasofneurobiologyandanumberofsoftwarepackagesallow scientistswithminimalcomputerscienceandmathematicalbackgroundstocon- structseriousneuronalmodels. Asecondfactorleadingtotheproliferationof modelingstudiesisthedevelopmentoftechnologiesthatallowthekindsofdata collectionneededtodeveloprealisticmodelsofcorticalneurons. Characterization ofthekineticsofvoltage-andligand-gatedchannelsandreceptorshadbeenlim- itedtorelativelylargeneurons. However,therapiddevelopmentofsliceprepara- tions,patch-clampmethods,andimagingmethodsbasedonvoltage-sensitivedyes andintracellularcalciumindicatorshasresultedinasignificantdatabaseonthe biophysicalfeaturesofcorticalneurons. Thescopeofmodelingapproachestocorticalneuronsandfunctionsiswide anditseemednecessarytolimitthepurviewofthevolume. Thefocusisonattempts tounderstandthepropertiesofindividualcorticalneuronsandneuronalcircuitry throughmodelsthatincorporatesignificantfeaturesofcellularmorphologyand physiology. Noattemptwasmadetoincludemodelingapproachestounderstanding corticaldevelopmentandplasticity. Thus,workdealingwiththedevelopmentof oculardominancecolumnsandtheorientationselectivityofneuronsinvisualcortex isnotconsidered. Similarly,modelsdealingwiththecellularmechanismsunderlying long-termplasticityandwithapproachestolearningandmemorybasedonmodifica- tionofHebbiansynapsesarenotconsidered. Relativelyabstractattemptstounder- standhigherlevelandcognitiveprocessesbasedonneuralnetsrepresentasecond, majorareaofworkthatisnottreated. Modelsofcognitiveprocessesbasedon dynamicalsystemsmethodsinwhichnoattemptismadetoincludethebiophysical featuresofindividualneuronsarealsonotconsidered. vii viii Thetenmajorchaptersfallintothreegroups. Thefirstgroupdealswith compartmentalmodelsofindividualcorticalneurons. LyleBorg-Grahamprovides PREFACE anintroductiontothemethodsinvolvedinconstructingcompartmentalmodels andthenreviewstheexistingmodelsofhippocampalpyramidalcells. Becauseof theeffectivenessofhippocampalslicepreparations,theseneuronshavewell-ehar- acterizedbiophysicalproperties. Thischapterillustrateshowcompartmentalmod- elscanbeusedtosynthesizeexperimentaldataandprovideanintegrativeviewof thepropertiesofindividualneurons. PaulRhodescontinuesthethemebyfocusing ontheroleofvoltage-gatedchannelslocatedonthedendritesofcorticalneurons. Thisisanareainwhichtechnologicaladvancesinthevisualizationofneuronsin slicepreparationsbasedoninfraredmicroscopyhavegreatlyexpandedtheinfor- mationavailableondendriticfunctioninjustafewyears. Thechapterbothreviews theexperimentaldataonactivedendriticconductancesandemphasizestheirpo- tentialfunctionalroles. Thesecondgroupofchaptersdealwiththegenerationofreceptivefield propertiesofneuronswithinvisualcortex. Theyaddressissuesstemmingfromthe originalattempttounderstandhowthereceptivefieldpropertiesofneuronsincat andmonkeyprimaryvisualcortexaregeneratedbyinteractionsbetweengenicu- lateafferentsandcorticalneurons. ThechapterbyFlorentinWorgotterevaluates modelsthathavebeenusedtoanalyzethegenerationofreceptivefieldproperties. RodneyDouglasandhiscolleaguesaddressaspecificsetofissuesdealingwiththe roleofintracorticalexcitationmediatedbypyramidalcellcollaterals. Animportant featureofthischapterisitsrelationtoattempttoconstructfabricatedcircuitsthat duplicatethefunctionsofcorticalcircuits. ThechapterbyPhilipUlinskifocuseson thegenerationofmotion-selectivepropertiesincorticalneurons. Itseekstoidenti- tycellularmechanismsusedbyneuronsthatrespondpreferentiallytovisualstimuli movingwithparticularspeedsordirections. MatteoCarandiniandhiscolleagues discussthefeatureofcorticalneurons,knownasgaincontrol,thatallowsneurons torespondeffectivelytovisualstimulibypoolinginformationacrosspopulationsof corticalneurons. ThechapterbyHughWilsondealswiththereceptivefieldproper- tiesofextrastriateareasandintroducesnewworkanalyzingface-selectiveneurons. Thefinalsetofchaptersconsidermodelsofensemblesofthalamicandcortical neurons. ThechapterbyWilliamLyttonandElizabethThomasusesthetheoryof dynamicalsystemstoanalyzethetemporalrelationshipsbetweenthalamicand corticalneurons. Animportantfeatureoftheinteractionbetweenthalamusand cortexisthepresenceofoscillationsthatdependinpartuponthevoltage-gated conductancespresentonindividualneuronsandinpartonthestructureofthe overallnetwork. PaulBushcontinuesthisemphasisonoscillationsbydiscussinga modelthatdealswiththegenerationofsynchronizedoscillationsinvisualcortex. Oscillationsofthiskindhaveattractedsubstantialattentioninrecentyearsbecause oftheirpotentialroleincognitiveprocesses. Thelastchapter,byMichaelHasselmo andChristianeLinster,reviewstheirworkonmodelingpiriformcortex,emphasiz- ingtheroleofcholinergicmechanismsinmodulatingtheactivityofcorticalneu- rons. Anattempthasbeenmadethroughouttomakethevolumeaccessibleto readerswithminimalmathematicalbackgrounds. Thevolumethusbeginswitha shorthistoryofmodelsofcorticalneuronsandcircuitrythatintroducestheprinci- palmodelingstyles. ThechaptersbyWorgotterandUlinskicontainmoreextensive ix introductionstosomeofthemodelingmethodsthathavebeenusedtostudyvisual cortex,andthemathematicallychallengedreaderwillfindthatthechapterby PREFACE LyttonandThomascontainsareadableintroductiontotheuseofdynamical systemstheoryinneurobiology. PhilipS. Ulinski EdwardG. Jones Chicago and Davis Contents Chapter 1 ModelingCorticalCircuitry:AHistoryandProspectus PhilipS. Ulinski 1. Introduction "...1 2. LorentedeNothroughDynamicalSystemsModels...2 2. 1. LorentedeNo...2 2. 2. CellAssembliesandNeuralNets...3 2. 3. DynamicSystemsModels...8 3. HodgkinandHuxleythroughNetworkModels...11 3. 1. HodgkinandHuxley...11 3. 2. WilfridRall...11 3. 3. SoftwarePackages...13 3. 4. RealisticModelsofCorticalNetworks...14 4. Prospectus...14 5. References...15 Chapter 2 InterpretationsofDataandMechanismsforHippocampalPyramidal CellModels LyleJ Borg-Graham 1. Introduction...19 1. 1. NeuronModelEvolution-followingElectrophysiology...19 1. 2. NeuronModelEvaluation-followingtheParameters...21 1. 3. WhyHippocampus? 21 1. 4. OrganizationofThisChapter...22 xi xii 2. TheDatabaseforSingle-NeuronModels...23 2. 1. VoltageClampversusCurrentClamp...23 CONTENTS 2. 2. Single-ChannelversusMacroscopicCurrents...24 2. 3. TypeofPreparation...24 2. 4. KineticandPharmacologicalDissection...25 2. 5. TemperatureDependence...26 2. 6. AgeDependence...27 2. 7. HippocampalSubfieldDependence...27 2. 8. DifferencesinFiringPropertiesbetweenSharpversusPatch Recordings...28 2. 9. TheMeasuredVoltage...

2 3 4 5 6 7 8 9 1011 1 2 3 4111 This book provides coverage of a broad range of topics in the ?eld of neurosurgery, 5 for residents and registrars in training and for recent graduates of training programs. 6 As neurosurgical training incorporates expertise from centers worldwide, there is a 7 need to have input from specialists in neurosurgery from various countries. This text 8 is a compilation by expert authors in the USA and the UK to provide information on 9 the basic knowledge and clinical management required for optimal care of neuro- 2011 surgical patients. 1 The text is an up-to-date synopsis of the ?eld of neurosurgery from American and 2 British perspectives, which covers the most common clinical conditions encountered 3 by neurosurgeons. The chapters are organized under broad topics, including inves- 4 tigative studies, perioperative care, the role of newer techniques and the management 5 of tumors, vascular and traumatic lesions. Additional topics are then covered, includ- 6 ing pediatrics, spine and peripheral nerve lesions, as well as functional neurosurgery 7 and infections. We anticipate that trainees will ?nd this information useful for certi?- 8 cation examinations and recent graduates of neurosurgical training programs can 9 utilize this text as an update of the most important neurosurgical topics.

Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis, and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.

This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

This book identifies the 50 key scientific articles in the field of vascular and endovascular surgery. It provides a commentary to each carefully selected paper and explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area. There has been an exponential increase in the volume and quality of published research relating to vascular and endovascular surgery in recent decades. Among thousands of articles, a small fraction is truly "game changing." Such studies form the foundations of vascular surgery today and the selection of papers within this book provide the 50 landmark papers every 21st-century vascular and endovascular surgeon needs to know. A valuable reference not only to the established surgeon, but also to vascular surgery residents and trainees, as well as to more experienced surgeons as they continue to learn new techniques and approaches and to improve their knowledge of vascular disorders and treatments. The papers provide an evidence-based resource for those surgeons preparing for professional exams and may inspire clinicians to produce new research. About the Editors Juan Carlos Jimenez MD, MBA Professor of Surgery Gonda (Goldschmied) Vascular Center David Geffen School of Medicine at UCLA Los Angeles, California Samuel Eric Wilson, MD Distinguished Professor of Surgery and Chair Emeritus University of California Irvine Irvine, California

This practical guide is a compendium of contemporary views on the development, treatment, and prevention of urinary stone disease. Emphasis is placed on utilizing current research to highlight areas of potential discovery and inspire novel approaches to easing the burden of urinary stone disease.

Studies over the past decade have continued to bring tremendous advances to our understanding of bone biology. New pathways have been discovered and expanded our knowledge of the ways in which genes and gene products affect bone cells and thereby bone mass and bone strength. In Bone Research Protocols, Second Edition, expert researchers in the field detail many methods commonly used to study bone biology. Focusing mainly on in vitro methods, this volume gives techniques for isolation, culture and functional analysis of all bone cell types and details a range of imaging methods, including light and ultrastructural microscopy and live cell imaging. Some important in vivo techniques are included, such as analysis of bone resorption and imaging using X rays, fluorescent or luminescent techniques. Methods for study of proteins and nucleic acid are included and methods for analysis of bone composition, measurement of bone strength, and response to mechanical stimulation are described. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bone Research Protocols, Second Edition seeks to aid scientists in the bone field to establish new techniques in their laboratories.

As an addition to the European postgraduate training system for young neurosurgeons we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo Krayenbiihl. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have throughout been associated with this series. The fact that the English language is well on the way to becoming the international medium at European scientific conferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contributions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publi cation of any volume. Our series is not intended to compete with the publications of original scientific papers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fields and constitute the first part of each volume.

This book provides clinical tips on management of catastrophic emergencies that are regularly faced by critical care and acute care cardiologists in resource-limited settings. Based on the current guidelines, it explores the evaluation of the patient, followed by its treatment methodology. It highlights the beneficial effects of the use of cardiac drugs during an emergency. There is also a special section on preoperative evaluation and postoperative management of cardiac patients of different subsets. Medicolegal/documentation points have also been discussed where relevant. It is useful as a ready reference for physicians, anaesthetists and cardiologists. Key features: • Reinforces certain teachings and recalls certain overlooked clinical points to address emergency situations in a busy, resource limited setting. • Explains lucidly what the acute cardiac care / Anesthesia registrar or cardiology fellows ought to do in the Intensive care and Post operative wards. • Emphasizes the importance of wit, clinical acumen and observation.

British Medical Association Book Award Winner - Obstetrics and Gynaecology 2021 Trainees in Obstetrics and Gynaecology require robust operative skills, yet factors such as the implementation of structured training and increased litigation concerns have significantly limited training time. Whilst conventional textbooks are sufficient for presenting theoretical knowledge, they are inadequate in explaining practical procedures. How to Perform Operative Procedures in Obstetrics and Gynaecology thoroughly describes many key index operations in the Royal College of Obstetricians and Gynaecologists training syllabus, offering an innovative, media-rich approach to the subject. Written by a team of O&G practitioners, this unique resource combines concise written instructions, full-colour pictures and diagrams, and hours of high-quality video footage of real-life operations, narrated by experienced NHS consultants. Specialty trainees, MRCOG candidates and post-MRCOG doctors are provided clear, easy-to-follow guidance on procedures including assisted vaginal delivery, Caesarean section, abdominal hysterectomy, diagnostic and operative laparoscopy, cone biopsy, rigid cystoscopy and many others. Features a companion website containing more than six hours of video tutorials, vignettes and personal experiences Includes a colour WHO Surgical Safety Checklist Discusses non-technical aspects such as consent and understanding human factors Covers surgical instruments, surgical positioning, and sutures and needles Offers introductions, overviews, and "Top Tips" for each procedure to highlight important learning points An ideal study guide and reference for individual and group work alike, How to Perform Operative Procedures in Obstetrics and Gynaecology is indispensable for specialty trainees and those preparing for MRCOG examinations.

Mitral Valve Surgery (J.R. Pluth). Myocardial Augmentation Using Skeletal Muscle (R. Fietsam, L.W. Stevenson). Thoracic Transplantation (G.M. Deeb et al.). Coronary Bypass Grafting in Conjunction with Carotid and Valvular Disease (A.J. DelRossi, A.C. Cernaianu). Cardiac Anesthesia and Oxygen Delivery and Uptake in the Critically Ill (T.J. Gallagher). Complex Cardiac Surgery (D.A. Cooley). Cardiac Surgery without Transfusion (R.K. Spence). Physiology of Blood during Cardiopulmonary Perfusion (R.A. Vertrees, L. Brownstein). Postoperative Responses to Hypothermia (J.A. Fikkert). Cardiac Valve Replacement in the 1990s (S.K. Eckert). Intraoperative Care of the CABG Patient (G. Kaempf). ECMO (M. Kurusz). Biomaterials and the Development of Membrane Technology (J.P. Sites). The Physiologic Impact of Cardiac Surgery (B.R. Sakallaris). 3 additional articles. Index.

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior.
Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.