Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Neurosurgical procedures are becoming more common and are taking place in the operating room and in interventional suites. Procedures that used to be performed only at major academic institutions are also being done in small community hospitals, and anesthesiologists in private practice are being asked to care for these patients. In many cases, treatment options are controversial or rapidly evolving. Close cooperation between the anesthesiologist and neurosurgeon is essential to achieve optimal outcomes and early recognition of any adverse events so appropriate therapy can be implemented. Fundamentals of Neuroanesthesia is a comprehensive guide to neuroanesthesia that discusses neurophysiology, neuroanatomy, and neurosurgical procedures and offers practical approaches and solutions to administering neuroanesthesia and providing perioperative care for neurosurgical patients. Chapters emphasize clinical management of neurosurgical problems that may be encountered in community practice as well as major academic medical centers. Highlighted key points, figures, algorithms, and management procedures supplement the text. This book is a must-have volume for general anesthesiologists, anesthesiology fellows, and subspecialists.

Sports participation opportunities for individuals with impairments are increasing. Whether an athlete is beginning a sport or competing on the world stage for a podium finish, nutrition is recognized as being integral to optimizing their health, training capacity, and performance. Some athletes with impairments are physiologically similar to their able-bodied counterparts, whereby the application of sports nutrition principles is straightforward. However, athletes with certain impairments require a very individualized approach when applying these principles in a practical way. Fully updated and expanded, this second edition of Sports Nutrition for Paralympic Athletes is an essential resource for sports nutrition practitioners who work alongside athletes with an impairment, whether that be physical, visual, hearing, or intellectual. In addition to chapters devoted to each impairment type, this book covers specific areas including medical considerations, body composition, supplements, and practical aspects that can be applied across all athletes and sports. Case studies and messages from athletes and world-class coaches enhance the application of theoretical research into practice providing the most relevant sports nutrition advice to Para athletes. Features New chapters on energy availability in Para athletes and cooling and hydration for the Para athlete Concise review of current sports nutrition recommendations for athletes, both during training and in competition Provides practical guidance and examples on how to apply sports nutrition principles to each impairment type Includes real life experiences of Para athletes, elite coaches, and practitioners Encompasses wider topics of assessing body composition, medical considerations, and supplement use specific to Para athletes Features insight and experiences gained by practitioners over the three major Paralympic Games since the first edition Sports nutrition can be the difference between being competitive and making the podium. With the rapidly increasing Paralympic profile, this book is valuable for professionals endeavoring to give their athletes the competitive edge - it challenges, stimulates, and drives future research in this area to continue to improve the delivery of this intrinsic component of athlete preparation.

In order to achieve and maintain peak performance, high-level athletes require the right nutrition at the right time. Nutrition for Elite Athletes provides a comprehensive overview of the latest research on the nutritional requirements of athletes at the top of their game. Since researchers, clinicians, and graduate students work with certain populations of athletes, such as endurance athletes, and not single nutrients or metabolic systems, this book arranges topics by 1) athletic population and 2) nutrition /exercise interactions that reach across athletic sub-populations (such as recovery nutrition), instead of by nutrients or metabolic system. Bringing together the contributions of well-known experts from around the world, the book identifies the nutritional needs of endurance athletes, strength power athletes, team sport athletes, and weight class/aesthetic sport athletes. In addition to coverage of recovery nutrition and energy balance, the book: Reviews the foundations of energy metabolism Considers dietary supplements, food safety, and drug/nutrient/exercise interactions Examines hydration requirements for various types of athletes Explores how vitamins and minerals impact performance The book assumes an understanding of the terms discussed in introductory nutrition courses as well as an understanding of metabolic systems concepts taught in undergraduate nutrition and exercise physiology courses. By doing so, the authors are able to get right into detailing the nutritional needs of elite athletes. In addition to its appeal for dieticians, researchers, and clinicians working with elite athletes, this book is suitable for use as a textbook for upper-level exercise nutrition and metabolism courses.

Completely revised and updated, Nutrition Support for the Critically Ill Patient: A Guide to Practice, Second Edition presents an unbiased, evidence-based examination of critical nutrition across the life cycle. Taking a multidisciplinary approach, each chapter has been carefully designed to provide a comprehensive review of the literature and a detailed exploration of the practical application of this information. With chapters written by experts, you get the most pertinent and current knowledge available, bolstered by tables, figures, and case studies that make the information accessible. New Coverage in the Second Edition: Gut microbiota support Short bowel syndrome Chronic critically ill phenomenon Professional nutrition practice guidelines and protocols Ethical considerations Quality and performance improvement Many challenges remain when providing optimal nutrition to all patients under all conditions at all times. Divided into eight sections, the book covers metabolic issues, nutrients for critically ill patients, delivery of nutrition therapy, nutrition therapy throughout the life cycle, special interest groups, specific organ system failure, general systemic failures, and professional issues in the field. It keeps you informed and aware of the continuous accrual of knowledge needed to craft and provide optimal nutrition therapy for the critically ill patient.

The latest in this already classic series presents recent progress and detailed descriptions of standard procedures, to assist young neurosurgeons in their post-graduate training. With contributions from experienced European and American clinicians.

This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio-oncologists, pathologists, and basic scientists. The remainder of the book focuses on areas of controversy in the diagnosis, treatment, and follow-up of testicular cancer. In each case the evidence base is discussed and results from the most recent studies are reviewed, drawing attention to new findings that might alter treatment recommendations. The treatment-related chapters cover a broad range of issues, including the best approach in patients with poor-prognosis and recurrent disease and those with long-term toxicities. Relevant aspects of survivorship care are also addressed. The book will help clinicians and practitioners to achieve the goals of minimizing therapy and its side-effects without reducing efficacy in low stage disease, improving the cure rate in advanced disease, and enhancing follow-up and long-term survivorship.

This book offers a step-by-step guide to mental health assessment for bariatric surgery patients. A general introduction explains the concepts of bariatric psychology and psychiatry, their relevance in contemporary bariatric surgery, and reasons to include psychologists and psychiatrists in multidisciplinary teams taking care of bariatric patients. The following four chapters address the aspects of mental health that are investigated by bariatric psychology. The psychological processes analyzed here play a major role in influencing patients' perception of the outcomes of bariatric surgery and in determining their commitment to lifestyle changes and follow-up programs. The second part of the book includes nine chapters addressing the clinical conditions relevant to bariatric psychiatry. For each condition, the major focus is on the impact of psychopathology on bariatric surgery outcomes (weight loss, weight regain, quality of life) and the impact of surgery on its course (remission, worsening, de novo onset). Each chapter in this part includes a discussion of the diagnostic instruments (i.e., structured interviews, clinician-rated tests, and patient-rated tests) that should be used to obtain a valid assessment of the patient's mental status. Separate chapters focus on psychiatric complications (e.g., suicide and addiction transfer) and psychological problems related to quality of life (e.g., body image dissatisfaction) that may emerge postoperatively. Data on these postsurgery conditions has been reported only recently and, therefore, no published book deals with them. The final chapter offers an overview of unsolved issues in bariatric psychology and psychiatry and reviews emerging research findings that are likely to change assessment and care of bariatric patients' mental health in the near future. Given its scope-and its wealth of tables, diagrams, mnemonics, and key fact boxes-the book will be an invaluable reference tool for clinicians.

As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. These patients pose unique challenges as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.

Wireless Cortical Implantable Systems examines the design for data acquisition and transmission in cortical implants. The first part of the book covers existing system level cortical implants, as well as future devices. The authors discuss the major constraints in terms of microelectronic integrations are presented. The second part of the book focuses on system-level as well as circuit and system level solutions to the development of ultra low-power and low-noise microelectronics for cortical implants. Existing solutions are presented and novel methods and solutions proposed. The third part of the book focuses on the usage of digital impulse radio ultra wide band transmission as an efficient method to transmit cortically neural recorded data at high data rate to the outside world. Original architectural and circuit and system solutions are discussed.

This newly revised edition contains updated versions of all of the topics that were in the first edition and has been substantially expanded with an additional 5 chapters. Each chapter includes information from the most up-to-date research on how nutritional factors can affect bone health, written with an evidence-based focus and complete with comprehensive references for each subject. Nutrition and Bone Health, second edition covers all aspects of nutrition and the skeleton, from the history and fundamentals, to the effects of macronutrients, minerals, vitamins, and supplements, and even covers the effects of lifestyle, the different life stages, and nutrition-related disorders and secondary osteoporosis. New chapters include HIV & AIDs and the skeleton, celiac disease and bone health, and nutrition and bone health in space. Nutrition and Bone Health, second edition is a necessary resource for health care professionals, medical students, graduate students, dietitians, and nutritionists who are interested in how nutrition affects bone health during all stages of life.

Key Features: • Features case-based scenarios in Critical Care as well as has a section on Tropical Diseases. • Appeals to a wide audience of trainees and consultants of Critical Care Medicine, Internal Medicine, Anaesthesiology, Pulmonary Medicine and those working in the ICU, due to its clinical relevance. • Reduces the dependency on the radiologist and help the physicians to save time which would enhance the quality of patient care.

With coverage of every aspect of the diagnosis, evaluation, and treatment of fractures involving the tibial plateau, Tibial Plateau Fractures delivers authoritative, up-to-date guidance on these complex injuries in one convenient source. Focused, easy-to-read content is presented in a templated, bulleted format for quick reference, providing easy access to the knowledge and experience of editor Dr. John Riehl and expert contributing authors. Numerous high-quality x-rays, MRIs, and clinical photos guide you step by step through the care of patients with tibial plateau fractures. Offers in-depth coverage of everything from evaluation, temporizing care, and complex decision-making involving implants and soft-tissue reconstruction to new and emerging technologies in this rapidly evolving field. Provides complete, well-illustrated operative coverage. Includes case examples and authors' tips and clinical pearls at the end of every chapter. Brings you up to speed with current treatment of associated soft tissue injuries and newer fixation options as well as open reduction techniques and arthroplasty. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

In general, surgeons strive to achieve excellent results and ideal patient outcomes, however, this noble task is frequently failed. For patients, surgical complications are analogous to "friendly fire" in wartime. Both scenarios imply that harm is unintentionally done by somebody whose aim was to help. Interestingly, adverse events resulting from surgical interventions are more frequently related to system errors and a communication breakdown among providers, rather than to the imminent threat of the surgical blade "gone wrong". Patient Safety in Surgery aims to increase the safety and quality of care for patients undergoing surgical procedures in all fields of surgery. Patient Safety in Surgery, covers all aspects related to patient safety in surgery, including pertinent issues of interest to surgeons, medical trainees (students, residents, and fellows), nurses, anaesthesiologists, patients, patient families, advocacy groups, and medicolegal experts.

Key features: • Expanded first chapter on levels of echocardiography. • New sections on COVID-19, cardio-oncology, multivalve disease, and specialist valve clinics. • Incorporation of new international guidelines, grading criteria and normal data. • Guide to how cardiac CT and magnetic resonance can compliment echocardiography. • Reformatted text and extra diagrams and tables to improve understanding.

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application - from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

First Published in 1981, this book offers a full, comprehensive guide to experimental stomatology. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine, and other practitioners in their respective fields.

This Vascular Surgery Atlas is a 'How to' book that allows the reader to focus on the technical aspects of the most commonly performed vascular procedures. The book is edited by two seasoned vascular surgeons with a well established experience in surgical education. The authors have been selected from both sides of the Atlantic to provide the expertise necessary to cover the various procedures.The atlas is focused on open surgical procedures and also covers essential endovascular procedures such as 'Endovascular Abdominal Aortic Aneurysm Repair and Carotid stenting.' It also includes a section on exposures of the infrainguinal vessels. The format allows the reader to easily follow the various steps of procedures. The art work shows all the details necessary to understand the anatomy and the technical aspects of the procedure. The layout of having text on one side and the associated art on the opposite page allows the reader to easily follow and understand the various steps on the described procedure.The atlas will benefit surgical residents, vascular surgery fellows and vascular surgeons.

The fifth edition of this bestselling Oxford Medical Handbook is now even better than ever, with the inclusion of three new chapters on day case surgery, remote and rural surgery, and emergency surgery. It has been thoroughly revised with the latest guidelines, management algorithms, and guidance on decision-making. Now with the editorial team expanded to include four new associate editors, this new edition provides an accessible pocket reference for surgical trainees, medical students, and all those involved in the care of the surgical patient. It is thoroughly comprehensive, without sacrificing the clear, concise, and quick-reference style the Oxford Medical Handbooks are known for. It provides surgically relevant anatomy and physiology, quick reference symbols, key diagrams, and a focus on evidence-based practice with key references throughout. This essential guide will ensure you have the information you need at your fingertips.

This edited volume comprises chapters written by experts in Asia, where osteoporosis and the related fractures have created an enormous burden on the healthcare system due to increase in aging population. The topics covered include the epidemiology, diagnosis and both medical as well as surgical treatment of osteoporosis, particularly of the spine. This book provides practical diagnostic methods and useful treatments for this important medical issue. The multi-faceted and evidence-based approaches make it a very helpful reference for doctors to decide the best methods of treatment for patients with osteoporosis of the spine.

"When a thing ceases to be a subject of controversy, it ceases to be a subject of interest. " WILLIAM HAZLITT (1778-1830) This is the fourth volume in a series which we started in 1997. In 1976, Varco and Delaney edited a "surgical bestseller" entitled Controversy in Surgery. This was fol lowed by a second volume in 1985. The immense success of these books among both surgical trainees and experienced surgeons, and their wide international ap peal, supported the editors' notion that a view of controversy is integral to teach ing. However, despite major advances in surgical science and practice, no other similar publication has since been put together with the objective of addressing major controversies in surgery. The aim of this series is to address such deficiency by covering the most crucial current controversies in general, vascular and trauma surgery. Since almost everything is controversial in surgery, we will be able to tackle different issues almost each year. The editors have selected a nationally/internationally recognized authority for each topic. Most books available today are either "North American: ' "British-Com monwealth" or "British-European: ' contributing to the constant transatlantic rival ry. Our series specifically aims to bridge this "culture gap" and includes North American, British, European, and other authors while maintaining a cohesive structure. This will hopefully also broaden the appeal of such a book across both sides of the Atlantic and beyond."

1.The Core Surgical Training interview has a format much closer to that of an exam than any 'traditional' job interview - this book covers the key aspects of this exam- interview. 2. Candidates using this book to revise and practice their answers to the common interview questions/scenarios will score the highest. 3. Easy to use A-Z format assists easy memorization of key facts.

Stereo EEG has revolutionized the way invasive EEG explorations are performed, facilitating the assessment of more complex cases with increased precision, a lower surgical risk, and better patient outcomes. A Practical Approach to Stereo EEG is the first dedicated reference on stereoelectroencephalography written for trainees, physicians, and technologists involved in invasive EEG evaluation and monitoring. This go-to resource provides a practical overview of the concepts, methodology, technical requirements, and implantation strategies for common and uncommon surgical epilepsies amenable to stereo EEG. Including over three hundred detailed figures, anatomical drawings, and MRI correlations, this guidebook is an indispensable tool for anyone training, practicing, and teaching in the field.With chapters written by leading experts from around the world, the book is divided into 10 sections covering noninvasive evaluation, technical aspects, electrode planning, practical approach for specific epilepsies, surgical placement in adults and children, interpretation, brain mapping, surgical procedures, and outcomes. Chapters integrate highlighted key concepts with illustrative case examples throughout to enhance clinical applicability. Four detailed case discussions of specific epilepsy syndromes covered in the book are also available online to demonstrate the process of patient evaluation, surgical planning, and decision-making in a multidisciplinary patient management conference. A Practical Approach to Stereo EEG is the essential comprehensive clinical handbook for practitioners at any level of training or experience involved in invasive EEG evaluations or working at surgical epilepsy centers. Key Features: Covers all practical aspects of stereo EEG, including the methodology, technical requirements, and strategies to successfully perform and interpret invasive monitoring Highly illustrated cases are interwoven within chapters to heighten clinical use World-class contributors with global expertise provide hands-on experience in successful use of stereo EEG in complex situations Additional online chapter-based narrated cases discuss specific epilepsy syndromes Purchase includes access to ebook available on most devices and computers