Written by an author with plenty of experience holding a scalpel, Dr. David Schneider's The Invention of Surgery is an in-depth biography of the practice that has leapt forward over the centuries from the dangerous guesswork of ancient Greek physicians through the world-changing "implant revolution" of the twentieth century. The Invention of Surgery explains this dramatic progress and highlights the personalities of the discipline's most dynamic historical figures. It links together the lives of the pioneering scientists who first understood what causes disease, how organs become infected or cancerous, and how surgery could powerfully intercede in people's lives, and then shows how the rise of surgery intersected with many of the greatest medical breakthroughs of the last century, including the evolution of medical education, the transformation of the hospital from a place of dying to a habitation of healing, the development of antibiotics, and the rise of transistors and polymer science. And as Schneider argues, surgery has not finished transforming; new technologies are constantly reinventing both the practice of surgery and the nature of the objects we are permanently implanting in our bodies. Schneider considers these latest developments, asking "What's next?" and analyzing how our conception of surgery has changed alongside our evolving ideas of medicine, technology, and our bodies.

Pediatric Urology: Evidence for Optimal Patient Management provides pediatric urologists the information needed for state-of-the-art patient care. Chapters are organized around pertinent clinical questions within major areas of pediatric urology, answered using the best available data while also reporting areas for which there is poor evidence. The text includes randomized controlled trials and prospective observational studies, tables that summarize important studies, and figures that illustrate algorithms with best options for management and their expected results. With an easy to use format not found in other volumes, Pediatric Urology: Evidence for Optimal Patient Management is an indispensible and unique resource for experienced pediatric urologists, pediatric surgeons, general urologists with an interest in pediatric urology, as well as fellows and residents in training.

volume of conference proceedings reviews the general pathophysiological significance of the isoforms of cyclooxygenase, and the likely value of selective COX-2 inhibitors in the treatment of rheumatoid conditions. Also covered is the possible use of antibodies against cytokines and cell adhesion receptors in the treatment of inflammatory conditions.

The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.

This detailed second edition provides key updates on well-established methods as well as coverage of recently emerging sophisticated techniques and methods that are essential for an in-depth and state-of-the-art understanding of skeletal development and homeostasis and the pathological mechanisms that cause skeletal degeneration. The first half of the book examines cell and molecular biological aspects of osteoarthritis and osteoporosis, while the remainder of the collection focuses on in vivo models of skeletal tissue injury, degeneration, and repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Osteoporosis and Osteoarthritis, Second Edition aims to assist investigators concerned with research topics broadly related to osteoporosis, osteoarthritis, intervertebral disc degeneration, as well as other musculoskeletal disorders.

This book illuminates how crucial transformations in medical politics and organization were linked to wider changes in society, economy and ideology. Paying particular attention to developments in medical welfare for physically handicapped children, wounded soldiers and injured workers, this documented study challenges conventional accounts of medical specialization, provides Anglo-American comparisons and demonstrates the importance for medical modernity of changing interactions between philanthropy, war, labour, capital and the state.

Unique in the field, Comparative Management of Spine Pathology presents commonly encountered spinal cases with side-by-side, case-by-case comparisons that clearly show how various experts would handle the same case. This second volume in the Neurosurgery: Case Management Comparison Series offers multiple opinions from international experts in both neurosurgery and orthopaedics, each of whom explains their preferred approach and management style for the same case. This format allows for quick and helpful comparisons of different ways to approach a lesion, advantages and disadvantages of each approach, and what each expert is looking for in how they would manage a particular case. Offers 4 expert opinions on each case in a templated format designed to help you quickly make side-by-side comparisons-an ideal learning tool for both trainee and practicing neurosurgeons and orthopaedic surgeons for board review and case preparation. Helps you easily grasp different approaches to spine management with different expert approaches to the same case and summaries from the editors on the advantages and disadvantages to each approach. Features a wide variety of management decisions, from preoperative studies to surgical approach, surgical adjuncts, and postoperative care, from experts in the field who specialize in different aspects of spine surgery. Presents 70 cases in the areas of degenerative spine, traumatic spine, spinal deformity, spinal oncology, and miscellaneous topics such as epidural abscess, osteomyelitis, and post-instrumentation infection. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text and figures from the book on a variety of devices.

This book explores the intricate connections that link the current digitalization of manufacturing to our daily lives and identities as members of highly technologized societies. Based on extensive research on the prosthetics industry in Germany, the USA, Canada, and Haiti, the author demonstrates the socio-material construction of users, examining the ways in which the introduction of 3D printing changes how artificial limbs are designed, manufactured, distributed and used. Addressing questions surrounding the capacity of flexible production to afford greater diversity of user roles, and the likelihood of 3D printing allowing for open-source hardware and the democratization of production, the author presents a theory of digitalization that sheds light on the dynamics of industrial transformation and the future of use. An empirically grounded and conceptually informed study, The Socio-Material Construction of Users will appeal to researchers in the fields of sociology, science and technology studies and organization studies, as well as readers interested in 3D printing and the digitalization of society.

Critical care medicine comprises the observation, diagnosis, treatment, and rehabilitation of patients with overt or potential failure of vital functions. Unlike other, bulkier reference texts, Handbook of Acute Critical Care Neurology focuses on one topic for quick and easy use on the job. Written by a highly respected expert in the field, this book will be extremely helpful for the practioner.

"Merkel Cell Carcinoma" is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world.

Features:

. Comprehensive single-source clinical reference

. Treatment focus

. Written for practitioners, with emphasis on clinical relevance and quick retrieval of information

. Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology

. International in perspective, with contributors from US and abroad

.Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters

This new book from leading neurosurgeon and author Gary Kraus is an account of traumatic brain injury (TBI) from the time a brain-injured patient arrives in the emergency department through to the wide range of clinical outcomes of such an injury. Written with the voice of experience, the author examines causation of TBI, the patient’s stay in the neuro-intensive care unit and the many neurological assessments and tests that inform the outcomes that the patient and their families will encounter. A wide range of medical professionals will benefit from Dr Kraus’s acute insights into TBI including Neurosurgical residents, Neurosurgeons with a sub-specialist interest in Neuro-Trauma, Neurologists managing patients with post traumatic brain injury, Neuro-Intensivists, Neuro-Psychologists, Researchers/scientists involved in Clinical trial in traumatic brain injury, and those with a specialist interest in Neuro-rehabilitation.

Cracking the Intercollegiate General Surgery FRCS Viva: A Revision Guide 2e provides the framework and knowledge to pass the non-subspecialty sections of the FRCS (General Surgery) viva and clinical examination. This comprehensive and up to date revision text covers all essential topics in critical care, emergency and general surgery as well as research papers, basic statistics and data manipulation for the academic section.This essential revision guide provides you with the vital points for each topic, presented in a concise, structured manner and referenced where appropriate. It is essential reading for anyone preparing for the FRCS General Surgery exam.

This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field. Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.

Sole reference in the field of orthopedic surgery

* condenses and summarises the key information presenting it in a fashion that is succinct and easy to understand. * The authors are leaders in their field and have a wealth of knowledge about the subject matter * SBA questions for each chapter, including answers

One in two of us will develop cancer at some point in our lives and yet many of us don't understand how cancers arise. How many different kinds of cancer are there? What treatments are available? What does the future hold in terms of developing new therapies? This book demystifies cancer by explaining the underlying cell and molecular biology in a clear and accessible style. It answers the questions commonly asked about cancer such as what causes cancer and how cancer develops. It explains how DNA makes proteins and how mutations can corrupt those proteins. It also gives an overview of current therapies and how treatments may advance over the next decades, as well as explaining what actions we can take to help prevent cancer developing. Understanding Cancer is an accessible and engaging introduction to cancer biology for any interested reader.

Bone Resorption, the second volume of the series Topics in Bone Biology, is centered on the osteoclast, the bone-resorbing cell. The volume thus c- plements the ?rst volume of the series, Bone Formation, which discussed origin, function, and pathology of the bone-forming cell, the osteoblast.Both volumes are addressed to scientists and clinicians who are active in or wish to enter the ?eld of skeletal function; this group encompasses a wide variety of specialties, including orthopaedics, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Rubin and Green?eld, in the ?rst chapter, discuss the origin and differ- tiation of the osteoclast. Recognized as a multinuclear cell about 150 years ago, its origin was not uncovered until a century later when, as a result of an experiment in which quail and chicken cells were co-cultured, it became clear that osteoclasts arose from hematopoietic stem cells.The authors then discuss the osteoclastogenic factor, now known as RANKL; the inhibitory binding protein, osteoprotegerin (OPG); and the complex signaling pathway that leads to differentiation and late differentiation of this complicated cell. A section of the chapter is devoted to a concise discussion of regulators and repressors of osteoclast differentiation, including sex steroids, calcitonin, nitric oxide, and mechanical factors. The chapter concludes that the ost- clast modulates bone development, bone growth, and

Atlas of Selective Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer emphasizes a multidisciplinary approach combining the experiences of a nuclear medicine physician, surgeon, and pathologist. This is an important reference also for researchers and clinicians who want to become familiar with sentinel lymph node mapping. The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin. Therefore, the logical approach is to harvest that specific SLN for thorough analysis.

This book offers a historical account of the development of the On-X carbon mechanical heart valve, discussing the steps involved in developing the materials, and describes how the design of the valve has evolved over the years. It explores both the scientific and corporate problems researchers have encountered over the years in the journey of making a mechanical heart valve. The chapters provide a detailed description of the design of the mechanical leaflet-based prosthetic valve, with a particular focus on blood flow characteristics. This book includes an overview of the state-of-the-art in the chemistry and physics of carbon, and compiles the advances in carbon-based technology and its applications in cardiac and thoracic surgery. This is an ideal book for bioengineers working on the chemistry and physics of carbon, and other professionals involved with cardiac and thoracic surgery.

According to the International Association for Ambulatory Surgery (IAAS), ambulatory surgery should be defined as 'an operation/procedure, excluding an office or outpatient operation/procedure, where the patient is discharged on the same working day'. The rise of ambulatory surgery has been driven by technological advances that reduce the need for overnight hospital stays, enhanced recovery programmes that advocate early mobilisation, and the need for economic efficiency. Recent experience has shown that redistributing surgical procedures from the inpatient setting to ambulatory centres can be done without impacting quality. The majority of people requiring urologic surgery are now treated as day/outpatients thus requiring a different level of care from inpatients. Ambulatory Urology and Urogynaecology is the only book that combines urology and urogynaecology focuses on outpatient management. Packed with learning points, practical hints and tips, and boasting an international group of contributing authors, this book is co-edited by world-leading pioneers in urologic and urogynaecological surgery. Ambulatory Urology and Urogynaecology is ideal for urologists, urogynaecologists and gynaecologists, as well as specialist urology nurses and surgeons. With more and outpatient procedures being performed, this book is the perfect step-by-step guide to consult time and time again.