Prokaryotic Toxin-Antitoxins (Hardcover, 2013 ed.)

Prokaryotic Toxins - Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin - antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has "100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Release date:	October 2012
First published:	2013
Editors:	Kenn Gerdes
Dimensions:	235 x 155 x 25mm (L x W x T)
Format:	Hardcover
Pages:	368
Edition:	2013 ed.
ISBN-13:	978-3-642-33252-4
Categories:	Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > General
LSN:	3-642-33252-8
Barcode:	9783642332524

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