The Tohoku University Graduate School of Dentistry first introduced the concept of "Interface Oral Health Science", designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces. Therefore, it is critical to promote dental studies that integrate a wide range of interdisciplinary research as medicine, agriculture, material science, engineering, and pharmacology. With this incentive, international symposiums for interface oral health science have been held several times in the past. The concept has since refined and expanded, the result being the "Biosis-Abiosis Intelligent Interface," and projects aiming at the creation of highly functional and autonomic intelligent interfaces are ongoing. This book brings together a number of studies on incentives and projects by leading authors. Topics include biosis-abiosis interface of dental implants, biomaterials in interface science, biomedical engineering interface and cell manipulation and tissue regeneration. Readers not only from the field of dentistry but also many related areas will find this book a valuable resource.

Advances in Materials Science and Implant Orthopedic Surgery brings together experts from major university hospitals, materials scientists specializing in bio-materials, and development engineers working for implant manufacturers to address such issues as: mechanisms of fixation; foreign-body immune response; generation and consequences of ionic and wear debris; materials selection, design and manufacturing schemes; and surgical techniques to maximize the safety and efficacy of the devices.

are then selected and must meet the general 'biocompatibility' require ments. Prototypes are built and tested to include biocompatibility evalua tions based on ASTM standard procedures. The device is validated for sterility and freedom from pyrogens before it can be tested on animals or humans. Medical devices are classified as class I, II or III depending on their invasiveness. Class I devices can be marketed by submitting notification to the FDA. Class II and III devices require either that they show equivalence to a device marketed prior to 1976 or that they receive pre-marketing approval. The time from device conception to FDA approval can range from months (class I device) to in excess of ten years (class III device). Therefore, much planning is necessary to pick the best regulatory approach. 2. Wound Dressings and Skin Replacement 2.1 Introduction Wounds to the skin are encountered every day. Minor skin wounds cause some pain, but these wounds will heal by themselves in time. Even though many minor wounds heal effectively without scarring in the absence of treatment, they heal more rapidly if they are kept clean and moist. Devices such as Band-Aids are used to assist in wound healing. For deeper wounds, a variety of wound dressings have been developed including cell cultured artificial skin. These materials are intended to promote healing of skin damaged or removed as a result of skin grafting, ulceration, burns, cancer excision or mechanical trauma."

Integrates basic research and practical clinical information on the neuropsychology of epilepsy under one cover. Provides inside knowledge on how neuropsychological assessments are performed and evaluated. A comprehensive reference that will serve as a clinical resource for working with epilepsy patients. Epilepsy is a prevalent condition affecting approximately 1% of the general population. Its behavioral effects on cognition and memory can be as debilitating as the physical aspects caused by ongoing seizures. This book is intended primarily for clinical neuropsychologists who encounter patients with epilepsy, either through employment in academic medical centers or in general practice. The book is of particular value to those working in a comprehensive epilepsy center, as the volume provides extensive coverage of the many clinical procedures performed in that setting. Procedures reviewed in this volume include neuropsychological testing, the Wada procedures, and brain mapping. Chapters include descriptions of the purpose of these procedures, reviews of the recent literature, clinical vignettes, in addition to concrete recommendations on how to actually conduct the procedures. Many chapters provide examples of test forms and stimuli useful for conducting some of the procedures reviewed in this book. Neurologists and pediatricians will also find this book to be helpful, as many medical practitioners consider the activities of clinical neuropsychologists working in their settings to be somewhat mysterious. This book makes the details of neuropsychological practice in an epilepsy setting more accessible than what has been present in prior literature. Content Level Research Keywords Brain mapping - Children with epilepsy - Cognitive remediation - Epilepsy - Epilepsy in children - FMRI - MEG - Movement disorder - Neuropsychological testing - Refractory seizure - Seizure - Seizure disorder - Wada test Related subjects Neurology - Ne

Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

In his exceptionally thought-provoking and moving memoir, neurosurgeon Joseph D. Stern explores how personal loss influences the way physicians relate to patients and their families. How does a doctor who deals with the death of patients on a regular basis confront his own loss when his beloved family member is living out her last days? Despite a career as a neurosurgeon, Joseph Stern learned more about the nature of illness and death after his younger sister Victoria developed leukemia than his formal medical training ever taught him. Her death broke down the self-protective barriers he had built to perform his job and led to a profound shift in his approach to medicine. During the year of her illness, Dr. Stern developed a greater awareness of the needs of patients and their families; of the burdens they carry; of the importance of connection, communication, and gratitude; and of what it means to ask the right questions. Grief Connects Us intimately explores the impact of personal loss on physicians and the ways in which they integrate it into their professional lives, providing a blueprint for change that places compassion and empathy at the centre of the practice of medicine.

1.The Core Surgical Training interview has a format much closer to that of an exam than any 'traditional' job interview - this book covers the key aspects of this exam- interview. 2. Candidates using this book to revise and practice their answers to the common interview questions/scenarios will score the highest. 3. Easy to use A-Z format assists easy memorization of key facts.

Developments in the field of instrumentation of innovative instrumentation. Although laser applications have permeated nearly every aspect are among the major contributions to human advancement. The history of surgery has seen of surgical therapy, the expectations have fre many revolutionary developments cause quantum quently been unrealistic and the evaluation of leaps in progress. Electrocautery, the anesthesia technological development has always been machine, computed axial tomography, and the painfully slow. The properties of vaporization, surgical microscope are all revolutionary in coagulation, and cutting unified in an invisible struments that have irrevocably changed the shaft of light have enabled the neurosurgeon to direction of neurological surgery. vaporize inaccessible tumors of brain and spinal In the early stages of application, there are cord, harness recalcitrant bleeding sites, and cut always detractors and valid controversy concern through the most formidable calcified tumors. ing the value of a new instrument. Some will The application of this new energy form in remember those who argued that the magnifica tandem with the surgical microscope has, in my tion and illumination provided by the micro opinion, extended the scope of all aspects of scope were not valuable to the skilled surgeon neurosurgery. We have much more work to do. and would prolong the operative time and in lt is necessary to document improved results and crease infection rates. Others may recall that demand technological advances and safe inno Cushing was told to abandon the blood pressure vations."

This book encompasses many different diagnoses as well as several specialties of practicing surgeons in the United States. Over the last ten years many advances have been made in preoperative assessment including imaging and diagnostic techniques, operative approaches including "minimally invasive" and robotic surgery, and post operative care. Controversies in Thyroid Surgery explores some of the controversies that arise as the result of these new findings and applications. The book is divided into the two categories of benign diagnosis and cancer topics. Both of these areas lend themselves to separate analysis of specific problems in the areas mentioned above. The text reviews recent data about advances in diagnostic techniques as well as outcomes with specific regards to the newer operative techniques. The textbook will serve as a resource for medical and surgical colleagues involved in the treatment of a wide variety of thyroid diseases. Authors that are experts in their field and have published extensively provide balanced and non-biased views of topics that are admittedly controversial. Controversies in Thyroid Surgery will be of great value and utility to practicing endocrinologists, general surgeons and otolaryngologists.

The field of minimally invasive surgery (MIS) has now taken centre stage in modern clinical practice. With ever changing technologies in the field of MIS, such as robotics, there is now the need to train the surgeon to the next degree. Training by simulation, whether virtual, hybrid, or real, allows the surgeon to rehearse, learn, improve or maintain their skills in a safe and stress free environment.

"Simulation Training in Laparoscopy and Robotic Surgery" gives a true insight into the latest educational and learning techniques for new technologies in surgery. Written by an international team of experts, this illustrated text provides advice on specialised team training, non technical skills and simulation.

"Simulation Training in Laparoscopy and Robotic Surgery" is an important training aide for surgeons and residents interested in developing skills in this field.

"

Osteoporosis - an insidious and crippling skeletal disease characterized by low bone mass, systemic deterioration of bone tissue, and increase in bone fragility and susceptibility to fracture - has now reached epidemic proportions among postmenopausal women. This excellent collection of recent articles by specialists from medicine, nursing, nutrition, exercise physiology, physical therapy, and demography addresses the many challenges of a disease that for too long has been dismissed as a normal part of aging.
The volume first presents compelling statistics on the incidence and personal, social, and financial impact of this often preventable and treatable disease. Personal portraits then give a face and voice to those behind the statistics who are forced to cope with bent and fragile bones that may give way suddenly and painfully. Finally, encouraging information is offered on recent diagnostic and treatment breakthroughs that enhance doctors' ability to prevent and detect osteoporosis and better manage its unwelcome consequences.
Written in an accessible manner, this highly informative reference work will be of great interest to all women, especially those diagnosed with osteoporosis and their loved ones.

Principios de fisiopatologia quirurgica Actualmente, en la mayoria de las escuelas de Medicina y durante las residencias medicas, se acostumbra tener para cada materia, un libro de texto unico, el que frecuentemente es traducido de una lengua ajena al castellano. Los autores hemos pensado que el estudio de la Cirugia General, requiere no solo poder repetir algo escrito en una sola fuente de informacion, y menos que sea ajena a nuestro medio, sino que esta especialidad, al igual que las demas quirurgicas, obliga a un proceso ordenado de razonamiento, que dote al cirujano de una vision panoramica, basada en la informacion suficiente, que le permita entender el por que de las enfermedades a las que se enfrenta en su practica cotidiana. Esta obra, precisamente pretende sumarse al arsenal bibliografico del estudioso de la cirugia, para hacerle agradable el aprendizaje, dotarle de suficientes elementos para facilitar su quehacer cotidiano y, sin duda, proporcionarle no solo de principios para simplificar el proceso diagnostico, sino para justificar el tratamiento que le va a ofrecer a su paciente. Nos sentiremos mas que satisfechos si alcanzamos a despertar su curiosidad mas alla del contenido del texto, para verse obligado a complementarlo, con otras fuentes de informacion, asi como im genes, tratamientos, tecnicas quirurgicas etc.; es decir si logramos inquietarlo a seguirse preguntando por que? Pero...habremos, sin duda, superado nuestro proposito si ademas, conseguimos con ello, el que se maraville al descubrir los recovecos del inmenso universo que es la cirugia.

The purpose of this title is to provide a basis for tutors from which to teach undergraduate medical students. It is not intended to be a comprehensive work on paediatric surgery or to cover all the opinions on the subject, but rather to be a practical guide to what the general practitioner should know about paediatric surgery.

Cracking the Intercollegiate General Surgery FRCS Viva: A Revision Guide 2e provides the framework and knowledge to pass the non-subspecialty sections of the FRCS (General Surgery) viva and clinical examination. This comprehensive and up to date revision text covers all essential topics in critical care, emergency and general surgery as well as research papers, basic statistics and data manipulation for the academic section.This essential revision guide provides you with the vital points for each topic, presented in a concise, structured manner and referenced where appropriate. It is essential reading for anyone preparing for the FRCS General Surgery exam.

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Developments in tissue engineering for human medicine are increasing rapidly. Advances in stem cell biology, biomaterials science and scaffold design underpin this emerging science. An equally important facet of this field is the rational design and operation of bioreactors to control the nascent tissue growth. For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed.

Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth.

This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.