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Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia - Proceedings of the 6th International Symposium: Mechanisms of Secondary Brain Damage-Novel Developments, Mauls/Sterzing, Italy, February 1998 (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R4,461
Discovery Miles 44 610
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Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia - Proceedings of the 6th International Symposium: Mechanisms of Secondary Brain Damage-Novel Developments, Mauls/Sterzing, Italy, February 1998 (Paperback, Softcover reprint of the original 1st ed. 1999)
Series: Acta Neurochirurgica Supplement, 73
Expected to ship within 10 - 15 working days
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Information is provided from the basic and clinical sciences on the
mechanisms damaging the brain from trauma or ischemia. New aspects
involve the endoplasmic reticulum, mitochondrial failure,
pathobiology of axonal injury, molecular signals activating glial
elements, or the emerging therapeutical role of neurotrophins.
Experimental issues involve a better analysis of the ischemic
penumbra, the salvagable tissue. Therapeutic contributions reach
from the environmental influence to gene expression, including
neuroprotection, such as hibernation - mother nature's experiment -
or hypothermia which is reported to induce cell swelling. Treatment
issues deal also with thrombolysis and combination therapies, or
with the clearance of adverse blood components - LDL/fibrinogen -
by a novel procedure using heparin. Other highlights are discussing
the specificities of pediatric vs. adult brain trauma, or the
evolving role of the Apolipoprotein-E e4 gene in severe head
injury. An update is also provided on an online assessment of the
patient management during the pre- and early hospital phase in
Southern Bavaria. The empirical observation of neuroworsening is
analyzed in further details, whether this is a specificity
autonomously driving the posttraumatic course. Finally, the
unsolved question why drug trials in severe head injury have failed
so far in view of the promising evidence from the laboratory is
subjected to an expert analysis.
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