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Endocytosis and Exocytosis, Volume 4 (Hardcover)
Loot Price: R3,563
Discovery Miles 35 630
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Endocytosis and Exocytosis, Volume 4 (Hardcover)
Series: Biomembranes. A Multi-Volume Treatise
Expected to ship within 10 - 15 working days
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Volume 4 of Biomembranes covers endocytosis, exocytosis and related
processes. A major role of the plasma membrane is as a permeability
barrier, keeping the inside of the cell inside and the outside,
outside. Mechanisms must then exist to allow movement of material
between the cell and its environment. One mechanism for export from
the cell is by exocytosis, a process in which the membranes of
secretory vesicles fuse with the plasma membrane releasing the
contents of the vesicle into the extracellular medium. The process
has been studied in particular depth for the release of
neurotransmitters at the synapse. Import into the cell is possible
by the process of receptor-mediated endocytosis in which selected
plasma membrane proteins are internalizes; when these proteins are
receptors for macromolecules, the result is uptake of the
macromolecule. Transferring, the low-density lipoprotein, and
asialoglycoproteins are all taken up into cells in this way.
Phagocytosis, the ingestion of cells and cell fragments by
neutrophils and macrophages, also involves receptors - on the
phagocytic membrane - of which the best studied are those for the
Fc domain of IgG, for the third component of complement, and for
the mannose/fructose carbohydrates. Protection of a host against
infection can also be achieved by damaging the integrity of the
plasma membrane of the invading organism. This is the strategy
evolved by the cytotoxic T lymphocytes, which produce a
pore-forming toxin, perforin. Volume 4 of Biomembranes explores the
structures and mechanisms involved in these biologically and
medically important processes.
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