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Immunology of Endocrine Diseases (Paperback, Softcover reprint of the original 1st ed. 1986)
Loot Price: R1,533
Discovery Miles 15 330
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Immunology of Endocrine Diseases (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Immunology and Medicine, 3
Expected to ship within 10 - 15 working days
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Nineteen eighty-six is a most appropriate year in which to be
writing about developments in the organ-specific, autoimmune
endocrine diseases. It celebrates the publication 30 years ago in
1956 of the classic papers of Roitt and Doniach and their
co-workers I , and of Rose and Witebsky2 and Adams 3 and Purves .
These three sets of fundamental observations provided the initial
building blocks upon which much of what has been established in the
field in the last 30 years was built. No publication of this nature
on endocrine autoimmune disease can cover every aspect of the
subject. I have chosen to highlight the organs (thyroid and
pancreeas) which have attracted the most attention, and the areas
of work within these fields within which most research effort is
currently focused. There are still some gaps; the insulin and TSH
receptors are not considered, nor in any detail are the role of
cytotoxic mechanisms in mediating gland destruction. Molecular
biology will undoubtedly in the next few years clarify once and for
all the controversy that surrounds the structure of the TSH
receptor and T cell cloning, the role of cell-mediated
cytotoxicity. The pathogenetic mechanisms underlying autoimmunity
are increasingly well understood and the search for the aetiology
has begun.
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