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Phytochemicals, Signal Transduction, and Neurological Disorders (Hardcover, 2012 ed.)
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Phytochemicals, Signal Transduction, and Neurological Disorders (Hardcover, 2012 ed.)
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Phytochemicals Signal Transduction and Neurological Disorders
Phytochemicals are heterogeneous group of bioactive compounds
produced by plants, which are extensively researched by scientists
for their health-promoting potentials in human diseases. Unlike
vitamins and minerals, phytochemicals are not required for
sustaining cell viability, but they play an important role in
protecting tissues and cells from the harmful effects of oxidative
stress and inflammation. Examples of phytochemicals include
catechins, resveratrol, ginkgo biloba, curcumin, and sulfur
compounds found in garlic. Although, the precise molecular
mechanisms associated with beneficial effects of phytochemicals
still remain the subject of intense investigations, but it is
becoming increasingly evident that phytochemicals mediate their
effects by counteracting, reducing, and repairing the damage caused
by oxidative stress and neuroinflammation. In addition,
phytochemicals also stimulate the synthesis of adaptive enzymes and
proteins through the stimulation of a transcription factor called
Nrf2 and induction of phase II detoxifying enzymes. Consumption of
phytochemicals induces neurohormetic response that results in the
expression of adaptive stress-resistance genes that are responsible
for encoding antioxidant enzymes, protein chaperones, and
neurotrophic factor (BDNF). Based on the stimulation of signal
transduction network and adaptive stress-resistance genes, it is
proposed that the use of phytochemicals from childhood to old age
along with regular exercise is an important strategy for
maintaining normal aging and delaying onset of age-related
neurological disorders (stroke, Alzheimer disease, and Parkinson
disease). Phytochemicals Signal Transduction and Neurological
Disorders presents readers with cutting edge and comprehensive
information not only on bioavailability, and mechanism of action of
phytochemicals in the brain, but also provides the molecular
mechanism associated with beneficial effects of phytochemicals in
neurotraumatic (stroke, spinal cord trauma, and traumatic brain
injury) and neurodegenerative (Alzheimers disease, Parkinson
disease, Huntington disease, and amyotrophic lateral sclerosis)
diseases.
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