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The Human Oncogenic Viruses - Molecular Analysis and Diagnosis (Hardcover, 1986 ed.)
Loot Price: R3,188
Discovery Miles 31 880
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The Human Oncogenic Viruses - Molecular Analysis and Diagnosis (Hardcover, 1986 ed.)
Series: The Oncogenes
Expected to ship within 10 - 15 working days
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The early, organ-specific diagnosis of malignancy continues to be a
major unmet medical need. Clearly the ability to establish an early
diagnosis of cancer is dependent upon an intimate knowledge of the
cancer's biology, which if understood at the molecular level should
identify key diagnostic and therapeutic manipulation points.
Advances in recombinant gene technology have provided significant
understanding of the mechanisms of action of oncogenic viruses, as
well as of cancer-associated genomic sequences (onco genes). This
text will explore the known molecular genetic, biolog ical, and
clinical knowledge of selected human neoplasms that demonstrate
association with suspected oncogenic virus and those cytogenetic
alterations that either cause or are caused by oncogene activation.
The text first reviews the cytogenetics of human cancers link ing
classical cytogenetics and molecular genetics. Avery A. Sand berg
(Roswell Park Memorial Institute, Buffalo, New York) reviews the
leukemias and lymphomas, followed by S. Pathak (M. D. Anderson
Hospital and Tumor Institute, Houston, Texas), who reviews solid
tumors. Functional consideration of oncogenes is highlighted by
Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland)
through their description of the v-sis locus sis and its gene
product p.28; a protein that closely resembles human
platelet-derived growth factor (PDGF)."
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