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Pharmacology of Cytokines (Paperback)
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Pharmacology of Cytokines (Paperback)
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Cytokines are polypeptide mediators which act as communication
signals among cells of the immune system as well as among other
cells and tissues in the body. They are a heterogeneous and complex
group and include interferons, tumor necrosis factor and
chemokines. They play a key role in homeostasis and in host defense
and are involved in such inflammatory and autoimmune diseases such
as rheumatoid arthritis as well as infectious diseases such as HIV
infection and spetic shock. Modulation of the production and action
of cytokines, as well as their exploitation of therapeutic agents
has been the object of intense and competitive research. This book
overviews the field of cytokine research and describes the various
approaches that have been taken to develop the pharmacology of
these novel mediators. The pharmacology of cytokines is an
exploding area which is entering the clinical arena. The book in
the framework of the immunobiology of cytokines, examines the
interactions with the cytokine system of a variety of compounds
ranging from simple synthetic chemicals to biotechnological
products. In addition to examining individual agents and
approaches, the book examines the pathophysiology of individual
body systems and analyzes specific contexts for the pathophysiology
of individual body systems and analyzes specific contexts for the
pathophysiology of these mediators as well as pharmacological
approaches for their control.
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