Systems Biology (SB) is a suite of technologies and
methodologies that resulted, conceptually from the merging of two
basic paradigms, reductionism and holism with the goal of
identifying its emergent properties and defining, quantitatively,
molecular, cellular, tissue, organ and whole body processes. One
manifestation of SB is as a tool for hypothesis generation about a
system that is typically too large and complex to understand by
simple reasoning.
The US is currently well ahead of the rest of the world in the
development and application of SB and its principles especially as
they pertain to basic medical research and development.This lead is
largely due to its earlier start in the academic arena. However,
there is evidence of rapid development in both the UK/EU and Japan,
and the gap is narrowing, particularly in the UK. From an
industrial point of view, the Pharmaceutical Industry based in the
US and UK can capitalize on these opportunities and gain the
benefits of this technology. Many educational institutions
(particularly their medical divisions) at present are heavily
business-oriented, realize that in this particular industrial
environment, that every dollar counts.
This book intends to educate Cell and Molecular Biologists in
the use of the quantitative tools that are available to them to
help solve the critical problems they face. It is important that
biologists recognize early in their research the use and benefits
of SB and how this approach can help to generate new therapeutic
leads and substances useful for human health. Educational curricula
in the life sciences have typically been based on the belief that
one can dissect complex systems into their components and that a
detailed investigation of each these components individually will
in itself lead to novel biological insights, and indeed this is
true in numerous instances. However, increasing acknowledgment of
the importance of studying whole systems, as well as their
components, has led to an emphasis on teaching not just a
reductionist view of biology, but also a complementary
constructionist view.
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