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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cancer Stem Cells in Solid Tumors (Paperback, 2011 ed.)
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Cancer Stem Cells in Solid Tumors (Paperback, 2011 ed.)
Series: Stem Cell Biology and Regenerative Medicine
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The "cancer stem cell" hypothesis postulates that cancer arises
from a subpopulation of tumor-initiating cells or cancer stem cells
(CSCs). While the idea of cancer stem cells has been around for
more than a hundred years, evidence from the fields of hematology
and cancer biology has now demonstrated the critical role of stem
cells in hematological malignancies and suggested that these same
mechanisms are also central to the initiation, progression, and
treatment of solid cancers. Clinical and experimental studies have
shown that CSCs exhibit many classical properties of normal stem
cells, including a high self-renewal capacity and the ability to
generate heterogeneous lineages; the requirement for a specific
"niche"/microenvironment to grow; and an increased capacity for
self-protection against harsh environments, toxins, and drugs.
Cancer Stem Cells in Solid Tumors represents a detailed overview of
cancer stem cells and their role in solid cancers. Comprised of 24
chapters, this volume will provide readers with a comprehensive
understanding of this important and evolving field. Topics covered
include: Introduction of the CSC hypothesis Historical perspectives
and the contributing lessons from leukemia Current knowledge
regarding the identification and role of CSCs in various forms of
solid cancer including breast, brain, colorectal, pancreatic,
prostate, melanoma, lung, ovarian, hepatocellular, and head and
neck cancer Molecular pathways involved in driving CSC function,
with a particular focus on the novel convergence of embryonic and
tumorigenic signaling pathways In vitro and in vivo assays, model
systems, and imaging modalities for studying CSCs The clinical
importance of CSCs for cancer management and treatment, including
important implications for prognosis, prediction, and treatment
resistance Consideration of the controversy surrounding the CSC
hypothesis and important unanswered questions in this field This
collective work was written by a group of prominent international
experts in cancer biology, oncology, and/or stem cell biology. It
will serve as a valuable resource for established researchers,
professors, health care professionals, and students in the medical
and scientific community who are investigating stem cells and/or
oncology.
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