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Tissue Renin-Angiotensin Systems - Current Concepts of Local Regulators in Reproductive and Endocrine Organs (Paperback, Softcover reprint of the original 1st ed. 1995)
Loot Price: R5,513
Discovery Miles 55 130
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Tissue Renin-Angiotensin Systems - Current Concepts of Local Regulators in Reproductive and Endocrine Organs (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Advances in Experimental Medicine and Biology, 377
Expected to ship within 10 - 15 working days
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Recent progress in recombinant DNA technology and the availability
of a number of nonpeptide subtype-specific receptor antagonists and
of specific antibodies to components of prorenin-renin-angiotensin
system (PRAS) have led to rapid advances in the under standing of
the multifaceted role of angiotensin II, classically known as a
peptide hormone of cardiovascular homeostasis. Accumulating
evidence sug responsible for the regulation gests that, in addition
to its role in salt and water metabolism, PRAS may control other
physiological functions including neurosecretion, cellular
proliferation, hypertrophy and/or differentiation, angiogenesis and
gonadal function. At the same time, it is becoming evident that the
specialized functions of endocrine glands are not only regulated by
trophic hormones but also by locally produced paracrine/autocrine
factors. The concept is emerging that tissue PRAS is one such
locally active regulatory system. With more and more reproductive
and endocrine organs being added to the list of tissues that
contain a local tissue PRAS, questions are being raised by the
reproductive biologists and endocrinologists as to the role of such
systems in the tissues of their interest. On the other hand, the
cardiovascular and renovascular physiologists are wondering about
the relevance of PRAS in various peripheral tissues compared to
those of the classical cardiovascular organs. It appeared,
therefore, that the time was ripe for a meeting to consider a
merger of interest in these two important but heretofore distinct
areas of physiology."
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