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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Ion Channel Localization (Hardcover, 2001 ed.)
Loot Price: R4,676
Discovery Miles 46 760
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Ion Channel Localization (Hardcover, 2001 ed.)
Series: Methods in Pharmacology and Toxicology
Expected to ship within 10 - 15 working days
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Since the pioneering discoveries of Hodgkin, Huxley, and Katz, it
has been clear that specific ion conductance pathways underlie
electrical act- ity. Over the ensuing 50 years, there has been ever
increasing, and occasi- ally explosive, changes in the scope of
efforts to understand ion channel behavior. The introduction of
patch clamp technology by Erwin Neher and Bert Sakmann about 20
years ago led to the realization of the great variety of novel ion
channel species, and the subsequent revolution in cl- ing has
revealed an even greater diversity of the underlying molecular
entities. Today, advances in the study of ion channel structure and
function c- tinue at a high pace, from angstrom resolution imaging
of crystallized ch- nels to their genetic manipulations in animals.
In this regard, the field is a balanced one that inquires not only
what ion channel entities are there, or how they operate, but also
where are these molecular electronic switches? However, this
balance is not particularly well presented to the general sci-
tific audience or to specialists in the field. There are plenty of
wonderful and useful books and monographs, as well as conferences
and meetings on v- tually every aspect of ion channel structure and
function. However, we are unaware that the channel localization
theme has been considered in a u- fied forum.
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