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Cellular and Molecular Biology of Atherosclerosis (Paperback, Softcover reprint of the original 1st ed. 1992)
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Cellular and Molecular Biology of Atherosclerosis (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Argenteuil Symposia
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Atherosclerotic cardiovascular disease remains the major cause of
death and disability in Western society. The field of
atherosclerosis research has grown tremendously over the last forty
years, shedding a great deal of light on the contributing factors
and natural history of the disorder and enabling strategies for its
treatment and prevention. Some of the greatest strides in this
field in recent years have derived from advances in molecular
biology techniques. These strides were chosen for emphasis in the
most recent Princess Lilian symposium, whose proceedings this
volume represents. Historically, the Princess Lilian meetings have
been small ones aimed at bringing together investigators from
diverse specialties to discuss a particular subject. The most
recent meeting was no exception and included clinicians, clinical
investigators, and research ers in basic science. The symposium
began with an extensive review of coronary morphopathological
findings in patients who died of coronary heart disease. Any
rational hypothesis of atherogenesis must take into account
clinical findings, and any attempt to bridge the gap between
experimental laboratory findings and studies in man is highly
desirable. Three chapters focus on endothelial injury: one on the
nitric oxide pathway in physiology and pathology, a second on the
activation of endothelial cells, and a third on the monocyte and
endothelial injury. Still another chapter examines growth factors,
in particular the fibroblast growth factor in atherogenesis."
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