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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Diabetic Cardiomyopathy - Biochemical and Molecular Mechanisms (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R5,428
Discovery Miles 54 280
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Diabetic Cardiomyopathy - Biochemical and Molecular Mechanisms (Paperback, Softcover reprint of the original 1st ed. 2014)
Series: Advances in Biochemistry in Health and Disease, 9
Expected to ship within 10 - 15 working days
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Diabetes has long been recognized as a disease of high blood sugar,
and there has been a continuous search of the exact reason for its
development and effective treatment. In 2005, the World Health
Organization had estimated that more than 180 million people
worldwide suffer from diabetes mellitus and indicated that this
figure is likely to double within the next 20 years. Among the 3.8
million deaths each year associated with diabetes, about two thirds
are attributable to cardiovascular complications, and diabetes is
now considered to be a major metabolic risk factor for the
occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical
and Molecular Mechanisms is a compilation of review articles
devoted to the study on the topic with respect to biochemical and
molecular mechanisms of hyperglycaemia. The wide range of areas
covered here is of interest to basic research scientists,
clinicians and graduate students, who are devoted to study the
pathogenesis of diabetes-induced cardiovascular dysfunction.
Furthermore, some chapters are directed towards increasing our
understanding of novel ways for the prevention/treatment of
cardiomyopathy. Twenty five articles in this book are organized in
three sections. The first section discusses general aspects of the
metabolic derangements in diabetic cardiomyopathy including
metabolic alterations and substrate utilization as well as cardiac
remodelling in the heart; role of diet in the development of
metabolic syndrome in the heart; effect of hyperglycaemia in terms
of biochemical and structural alterations in heart. In the second
section, several cellular and molecular mechanisms are discussed
indicating that diabetic cardiomyopathy is a multifactorial and
complex problem. The third section discusses the prevention and
treatment of diabetes using appropriate diet, proper supplements
including antioxidants, angiotensin inhibitors and some other
drugs. All in all, this book discusses the diverse mechanisms of
diabetic cardiomyopathy with some information on new therapeutic
approaches for finding solutions to prevent or reverse the
development of cardiac dysfunction.
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