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Systems Biology: Simulation of Dynamic Network States (Hardcover, New)
Loot Price: R2,156
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Systems Biology: Simulation of Dynamic Network States (Hardcover, New)
Expected to ship within 12 - 17 working days
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Biophysical models have been used in biology for decades, but they
have been limited in scope and size. In this book, Bernhard O.
Palsson shows how network reconstructions that are based on genomic
and bibliomic data, and take the form of established stoichiometric
matrices, can be converted into dynamic models using metabolomic
and fluxomic data. The Mass Action Stoichiometric Simulation (MASS)
procedure can be used for any cellular process for which data is
available and allows a scalable step-by-step approach to the
practical construction of network models. Specifically, it can
treat integrated processes that need explicit accounting of small
molecules and protein, which allows simulation at the molecular
level. The material has been class-tested by the author at both the
undergraduate and graduate level. All computations in the text are
available online in MATLAB (R) and Mathematica (R) workbooks,
allowing hands-on practice with the material.
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