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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Biochemical immunology
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Immunosuppression - New Research (Hardcover)
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Immunosuppression - New Research (Hardcover)
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Immunosuppression involves an act that reduces the activation or
efficacy of the immune system. Some portions of the immune system
itself have immuno-suppressive effects on other parts of the immune
system, and immunosuppression may occur as an adverse reaction to
treatment of other conditions. Deliberately induced
immunosuppression is generally done to prevent the body from
rejecting an organ transplant, treating graft-versus-host disease
after a bone marrow transplant, or for the treatment of auto-immune
diseases such as rheumatoid arthritis or Crohn's disease. This is
typically done using drugs, but may involve surgery (splenectomy),
plasmapharesis, or radiation. A person who is undergoing
immunosuppression, or whose immune system is weak for other reasons
(for example, chemotherapy and HIV patients) is said to be
immunocompromised. When an organ is transplanted, the immune system
of the recipient will most likely recognise it as foreign tissue
and attack it. The destruction of the organ will, if untreated, end
in the death of the recipient. In the past, radiation therapy was
used to decrease the strength of the immune system, but now
immunosuppressant drugs are used to inhibit the reaction of the
immune system. The downside is that with such a deactivated immune
system, the body is very vulnerable to opportunistic infections,
even those usually considered harmless. Also, prolonged use of
immunosuppressants increases the risk of cancer. This book presents
the latest research in the field.
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