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Natural Product Biosynthesis - Chemical Logic and Enzymatic Machinery (Hardcover, 2nd New edition)
Loot Price: R3,132
Discovery Miles 31 320
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Natural Product Biosynthesis - Chemical Logic and Enzymatic Machinery (Hardcover, 2nd New edition)
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Authored by leading experts in the enzymology of natural product
biosynthesis, this completely revised and updated edition provides
a description of the types of natural products, the biosynthetic
pathways that enable the production of these molecules, and an
update on the discovery of novel products in the post-genomic era.
Although some 500 000 - 600 000 natural products have been isolated
and characterized over the past two centuries, there may be a
10-fold greater inventory awaiting immediate exploration based on
biosynthetic gene cluster predictions. The approach of this book is
to codify the chemical logic that underlies each natural product
structural class as they are assembled from building blocks of
primary metabolism. This second edition integrates many new
findings into the sets of principles of the first edition that
parsed categories of natural product chemistries into the
underlying enzymatic mechanisms and the catalytic machinery for
building the varied and complex end product metabolites. New
chapters include evaluation of a core set of thermodynamically
activated but kinetically stable metabolites that power both
primary and secondary metabolic pathways. Also, after decades of
uncertainty about the existence of various pericyclase classes, a
series of genome mining, heterologous expression, and enzymatic
activity characterization have validated a plethora of pericyclases
over the past decade. The several types of pericyclases are
involved in biosynthetic complexity generation of almost every
major category of natural products. This text will serve as a
reference point for chemists of every subdiscipline, including
synthetic organic chemists and medicinal chemists. It will also be
valuable to bioinformatic and computational biologists,
pharmacognocists and chemical ecologists, and bioengineers and
synthetic biologists.
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