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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Biomimetic Membranes for Sensor and Separation Applications (Hardcover, 2012)
Loot Price: R2,908
Discovery Miles 29 080
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Biomimetic Membranes for Sensor and Separation Applications (Hardcover, 2012)
Series: Biological and Medical Physics, Biomedical Engineering
Expected to ship within 10 - 15 working days
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This book addresses the possibilities and challenges in mimicking
biological membranes and creating membrane-based sensor and
separation devices. Recent advances in developing biomimetic
membranes for technological applications will be presented with
focus on the use of integral membrane protein mediated transport
for sensing and separation. It describes the fundamentals of
biosensing as well as separation and shows how the two processes
are working in a cooperative manner in biological systems.
Biomimetics is a truly cross-disciplinary approach and this is
exemplified using the process of forward osmosis will be presented
as an illustration of how advances in membrane technology may be
directly stimulated by an increased understanding of biological
membrane transport. In the development of a biomimetic
sensor/separation technology, both channels (ion and water
channels) and carriers (transporters) are important. An ideal
sensor/separation device requires the supporting biomimetic matrix
to be virtually impermeable to anything but the solute in question.
In practice, however, a biomimetic support matrix will generally
have finite permeabilities to water, electrolytes, and
non-electrolytes. These non-protein mediated membrane transport
contributions will be presented and the implications for biomimetic
device construction will be discussed. New developments in our
understanding of the reciprocal coupling between the material
properties of the biomimetic matrix and the embedded proteins will
be presented and strategies for inducing biomimetic matrix
stability will be discussed. Once reconstituted in its final host
biomimetic matrix the protein stability also needs to be maintained
and controlled. Beta-barrel proteins exemplified by the E. Coli
outer membrane channels or small peptides are inherently more
stable than alpha-helical bundle proteins which may require
additional stabilizing modifications. The challenges associated
with insertion and stabilization of alpha-helical bundle proteins
including many carriers and ligand and voltage gated ion (and
water) channels will be discussed and exemplified using the
aquaporin protein. Many biomimetic membrane applications require
that the final device can be used in the macroscopic realm. Thus a
biomimetic separation device must have the ability to process
hundred of liters of permeate in hours - effectively demanding
square-meter size membranes. Scalability is a general issue for all
nano-inspired technology developments and will be addressed here in
the context biomimetic membrane array fabrication. Finally a robust
working biomimetic device based on membrane transport must be
encapsulated and protected yet allowing massive transport though
the encapsulation material. This challenge will be discussed using
microfluidic design strategies as examples of how to use
microfluidic systems to create and encapsulate biomimetic
membranes. The book provides an overview of what is known in the
field, where additional research is needed, and where the field is
heading.
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