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The Organic Chemistry of Sugars (Paperback)
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The Organic Chemistry of Sugars (Paperback)
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Intrigued as much by its complex nature as by its outsider status
in traditional organic chemistry, the editors of The Organic
Chemistry of Sugars compile a groundbreaking resource in
carbohydrate chemistry that illustrates the ease at which sugars
can be manipulated in a variety of organic reactions. Each chapter
contains numerous examples demonstrating the methods and strategies
that apply mainstream organic chemistry to the chemical
modification of sugars. The book first describes the discovery,
development, and impact of carbohydrates, followed by a discussion
of protecting group strategies, glycosylation techniques, and
oligosaccharide syntheses. Several chapters focus on reactions that
convert sugars and carbohydrates to non-carbohydrate molecules
including the substitution of sugar hydroxyl groups to new groups
of synthetic or biological interest, cyclitols and carbasugars, as
well as endocyclic heteroatom substitutions. Subsequent chapters
demonstrate the use of sugars in chiral catalysis, their roles as
convenient starting materials for complex syntheses involving
multiple stereogenic centers, and syntheses for monosaccharides.
The final chapters focus on new and emerging technologies,
including approaches to combinatorial carbohydrate chemistry, the
biological importance and chemical synthesis of glycopeptides, and
the medicinally significant concept of glycomimetics. Presenting
the organic chemistry of sugars as a solution to many complex
synthetic challenges, The Organic Chemistry of Sugars provides a
comprehensive treatment of the manipulation of sugars and their
importance in mainstream organic chemistry. Daniel E. Levy, editor
of the Drug Discovery Series, is the founder of DEL BioPharma, a
consulting service for drug discovery programs. He also maintains a
blog that explores organic chemistry.
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