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Sense and Senility: The Neuropathology of the Aged Human Brain - The Neuropathology of the Aged Human Brain (Hardcover, 1997 ed.)
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Sense and Senility: The Neuropathology of the Aged Human Brain - The Neuropathology of the Aged Human Brain (Hardcover, 1997 ed.)
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nly two things are certain in life, one is that all of us will
inevita Obly grow older, the other is that at some point during or
at the end of this process we shall die. Inherent to the passage of
time is a deterio ration in the structural and functional integrity
of our bodies, this pro gressing to such an extent that one or more
organ systems will eventu ally begin to fail with the continued
health and well-being of the individual coming under threat.
Age-associated deficiencies in the musculo-skeletal,
cardiovascular, or endocrine systems producing arthri tis,
hypertension, stroke or diabetes are all too apparent in our
elderly population yet internally caused failures in the function
of the nervous system provide the common, and mostly intractable,
problems of memory and intellect or locomotion that face and
frustrate clinicians. Perhaps the most important factor which can
decide the outcome of research studies professing to examine the
effects of the passage of time (i. e. the 'process of aging') on
the function of the nervous system, or indeed any other organ
system, is the selection of appropriate or repre sentative subjects
for investigation. The heart of this problem lies in defining what
might be considered as 'normal' aging as distinct from
age-associated disease; setting the 'goal posts of normality'
continues to 1 be a matter of considerable debate."
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