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Patient-Specific Stem Cells (Hardcover)
Loot Price: R3,768
Discovery Miles 37 680
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Patient-Specific Stem Cells (Hardcover)
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One of the biggest challenges faced in medical research had been to
create accurate and relevant models of human disease. A number of
good animal models have been developed to understand the
pathophysiology. However, not all of them reflect the human
disorder, a classic case being Usher's syndrome where the mutant
mice do not have the same visual and auditory defects that patients
face. There are others which have been even more difficult to model
due to the multi-factorial nature of the condition and due to lack
of discovery of a single causative gene such as age-related macular
degeneration or Alzheimer's syndrome. Thus a more relevant and
accurate system will allow us to make better predictions on
relevant therapeutic approaches. The discovery of human pluripotent
stem cells in 1998 followed by the technological advances to
reprogram somatic cells to pluripotent-stem cell-like cells in 2006
has completely revolutionized the way we can now think about
modelling human development and disease. This now coupled with
genome editing technologies such as TALENS and CRISPRs have now set
us up to develop in vitro models both 2D as well as 3D organoids,
which can more precisely reflect the disease in the patients. These
combinatorial technologies are already providing us with better
tools and therapeutics in drug discovery or gene therapy. This book
summarizes both the technological advances in the field of
generation of patient specific lines as well as various gene
editing approaches followed by its applicability in various
systems. The book will serve as a reference for the current state
of the field as it: -Provides a comprehensive overview of the
status of the field of patients derived induced pluripotent stem
cells. -Describes the use of cardiac cells as a main featured
component within the book. -Examines drug toxicity analysis as a
working example throughout the book.
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