A great deal of new information has been obtained during the past
four years, and this monograph provides a clear and well reviewed
update on biochemical mechanisms and the results of important new
clinical studies using the interferons. Reviews include what is
presently known about the biosynthesis, physiological role and
mechanisms of action of the interferons (alpha, beta, gamma). New
biochemical information on interferon-receptor interactions and
signalling pathways is provided. The pharmacokinetic considerations
in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and
other solid tumors are reviewed with special emphasis on studies of
adjuvant chemotherapy in malignancies of the immune system.
General
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