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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Neuroendocrinology of Mood (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R3,049
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Neuroendocrinology of Mood (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Current Topics in Neuroendocrinology, 8
Expected to ship within 10 - 15 working days
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The tridecapeptide neurotensin (NT) was first identified in bovine
hypothalamic extracts and characterized by Carraway and Leeman
(1973,1975,1976) and has subsequently been found in all classes of
vertebrates (Carraway and Leeman 1976; Kitabgi et al. 1976; Kataoka
et al. 1979; Langer et al. 1979; Reinecke et al. 1980a; Cooper et
al. 1981; Grant et al. 1982; Carraway et al. 1982; Eldred and
Karten 1983), many invertebrates (Reinecke et al. 1980 b;
Grimmelikhuijzen et al. 1981; Price et al. 1982), and certain
bacteria (Bhatnagar and Carraway 1981). It is distributed
throughout the mammalian central nervous system (CNS) (Uhl and
Snyder 1977 a, b), gastrointestinal tract (Sundler et al. 1977;
Schultzberg et al. 1980), cerebrospinal fluid (CSF), adrenals,
pancreas, and plasma (Fernstrom et al. 1980). When administered
systemically, the peptide has a variety of effects such as
hypotension, hyperglycemia, decreased gastric acid secretion,
decreased gut motility, and altered secretion of anterior pituitary
hormones (Leeman and Carraway 1982). NT apparently does not cross
the blood-brain barrier in appre- ciable quantities; however, when
administered directly into the CNS, it produces a number of
physiological and behavioral effects. A burgeoning body of evidence
supports the role of NT as a neurotransmitter or neuromodulator.
Thus far, het- erogeneous CNS distribution, release of NT upon
neuronal depolarization, satu- rable and specific binding of NT to
receptors, and degradation by peptidases have all been
demonstrated.
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