The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis - The CAM assay in the study of angiogenesis and metastasis (Hardcover, Edition.)

* Several in vivo assays are currently used in the study of angiogenesis and antiangiogenesis * The chick embryo chorioallantoic membrane is one of the most common and versatile assay to study angiogenesis and antiangiogenesis in vivo * Angiogenesis plays a critical role in tumor progression and metastasis * Antiangiogenesis is one of most promising approach to the treatment of cancer and metastasis The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit th

General

Imprint:	Springer
Country of origin:	Netherlands
Release date:	February 2010
First published:	2010
Authors:	Domenico Ribatti
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Hardcover
Pages:	124
Edition:	Edition.
ISBN-13:	978-90-481-3843-2
Categories:	Books > Medicine > Other branches of medicine > Pathology > Gross pathology Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	90-481-3843-4
Barcode:	9789048138432

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