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Metabolic Interconversion of Enzymes 1973 - Third International Symposium held in Seattle, June 5-8, 1973 (Paperback, Softcover reprint of the original 1st ed. 1974)
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Metabolic Interconversion of Enzymes 1973 - Third International Symposium held in Seattle, June 5-8, 1973 (Paperback, Softcover reprint of the original 1st ed. 1974)
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The First International Symposium on the Metabolic Interconversion
of Enzymes was held in Santa Margherita Ligure, Italy, in May,
1970, under the direction of Professor G. Bonsignore. Because of
rapid developments in this field, a second Symposium was organized
a year and a half later in Rottach-Egern, Germany (October, 1971)
by Professors E. He1mreich, H. Holzer and O. Wieland. At that time,
so much new information had accumulated that it was decided to
repeat such conferences approx imately every other year; the United
States was chosen as the next site. This publi cation reports the
Proceedings of the Third International Symposium on the Metabolic
Interconversion of Enzymes held at the Battelle Seattle Research
Center, Seattle, Washington, June 5 - 8, 1973. The conferences were
originally designed to examine the control of metabolic reactions
by covalent modification of certain key enzymes. Covalent, as
opposed to allosteric or metabolic, regulation had first been
recognized some fifteen years be fore. Initially thought to
represent an added sophistication in regulatory processes possibly
reserved to higher organisms, covalent regulation has now been
found in both prokaryotes and eukaryotes. Those early studies in
covalent modification revealed for the first time the existence of
special "converter" enzymes whose purpose in life is to switch
other molecules from one state of activity to another."
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