Birth is a sudden, traumatic transition of environments. Once the
placental oxygen supply ceases, the foetus has only minutes to
establish pulmonary oxygen transport, which requires not only
inflation of the lungs, but also sudden and sustained changes in
the lung circulation. Not long ago, research in this field was
largely restricted to morphology and physiology. Now the powerful
new tools of cellular and molecular biology have begun to
shed light on the physiological processes in the developing lung
and its supporting vasculature.
In 22 chapters, three main sections explore lung growth and
development, vascular cell growth and differentiation, and the
mechanisms of hemodynamic control in the neonate; extensive
illustrations give a comprehensive picture of pulmonary circulatory
development. Factors controlling vasculogenesis and angiogenesis
are described by the scientists who pioneered the field. Similarly,
the intracellular signaling cascades that determine proliferation
or growth inhibition of fibroblasts, smooth muscle cells, and
endothelial cells are also presented in an understandable manner.
Finally, the role of
substances, such as nitric oxide and endothelin, that control the
hemodynamics of the fetal and neonatal circulations are discussed
in detail, particularly in relation to the changes occurring at
birth.
This book will inform basic scientists as well as the clinician
and student, and should be of particular interest to pediatric
cardiologists, pulmonary medicine physicians, and vascular
biologists.
General
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