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Membranes and Cell Signaling, Volume 7 (Hardcover)
Loot Price: R2,827
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Membranes and Cell Signaling, Volume 7 (Hardcover)
Series: Principles of Medical Biology
Expected to ship within 12 - 17 working days
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It should not come as too much of a surprise that biological
membranes are considerably more complex than lipid bilayers. This
has been made quite clear by the fluid-mosaic model which considers
the cell membrane as a two-dimensional solution of a mosaic of
integral membrane proteins and glycoproteins firmly embedded in a
fluid lipid bilayer matrix. Such a model has several virtues, chief
among which is that it allows membrane components to diffuse in the
plane of the membrane and orient asymmetrically across the
membrane. The model is also remarkable since it provokes the right
sort of questions. Two such examples are: Does membrane fluidity
influence enzyme activity? Does cholesterol regulate fluidity?
However, it does not go far enough. As it turns out, there is now
another version of this model, the so-called post-fluid mosaic
model which incorporates two concepts, namely the existence in the
membrane of discrete domains in which specific lipid-lipid,
lipid-protein and protein-protein interactions occur and ordered
regions that are in motion but remain separate from less ordered
regions. We must admit that both are intriguing problems and of
importance in guiding our thinking as to what the next model might
be.
We have chosen not to include the subject of membrane transport in
the present volume. This obviously represents a break with
convention. However, the intention is to have the topic covered
subsequent volumes relating to organ systems. It would be right to
regard this as an attempt to strengthen the integrated approach to
the teaching of medicine.
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