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Thermodynamics of Solutions - From Gases to Pharmaceutics to Proteins (Paperback, 2009 ed.)
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Thermodynamics of Solutions - From Gases to Pharmaceutics to Proteins (Paperback, 2009 ed.)
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This book consists of a number of papers regarding the
thermodynamics and structure of multicomponent systems that we have
published during the last decade. Even though they involve
different topics and different systems, they have something in
common which can be considered as the "signature" of the present
book. First, these papers are concerned with "difficult" or very
nonideal systems, i. e. systems with very strong interactions (e.
g. , hyd- gen bonding) between components or systems with large
differences in the partial molar v- umes of the components (e. g. ,
the aqueous solutions of proteins), or systems that are far from
"normal" conditions (e. g. , critical or near-critical mixtures).
Second, the conventional th- modynamic methods are not sufficient
for the accurate treatment of these mixtures. Last but not least,
these systems are of interest for the pharmaceutical, biomedical,
and related ind- tries. In order to meet the thermodynamic
challenges involved in these complex mixtures, we employed a
variety of traditional methods but also new methods, such as the
fluctuation t- ory of Kirkwood and Buff and ab initio quantum
mechanical techniques. The Kirkwood-Buff (KB) theory is a rigorous
formalism which is free of any of the - proximations usually used
in the thermodynamic treatment of multicomponent systems. This
theory appears to be very fruitful when applied to the above
mentioned "difficult" systems.
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