Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy (Hardcover, 1st ed. 2016)

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Resistance to Targeted Anti-Cancer Therapeutics, 9
Release date:	September 2016
First published:	2016
Editors:	Emmanuel Donnadieu
Dimensions:	235 x 155 x 13mm (L x W x T)
Format:	Hardcover
Pages:	199
Edition:	1st ed. 2016
ISBN-13:	978-3-319-42221-3
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Nursing & ancillary services > Specific disorders & therapies > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-319-42221-9
Barcode:	9783319422213

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