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Genomic Instability and Immortality in Cancer (Paperback, Softcover reprint of the original 1st ed. 1997)
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Genomic Instability and Immortality in Cancer (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Pezcoller Foundation Symposia, 8
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The eighth Annual Pezcoller Symposium, entitled Genomic Instability
and Immor- tality in Cancer, was held in Trento, Italy, June 17-19,
1996 and was focused on the clari- fication of the mechanisms of
genetic instability, a characteristic of neoplastic cells which
also determines tumor progression, and immortality consequent to
the lack of susceptibil- ity to mechanisms of maturations,
senescence and/or apoptosis. With presentations at the cutting edge
of progress and stimulating discussions, this symposium addressed
issues related to mutational lability, changes in DNA repair capa-
bilities, gene recombination processes, cell cycle checkpoints and
apoptosis, the signifi- cance of telomerases in cell
immortalization and senescence, and the clinical relevance and
exploitation of the phenomena considered. We wish to thank the
participants in the symposium for their substantial contribu- tions
and their participation in the spirited discussions that followed.
We would also like to thank Drs. Carol Greider, Garth Anderson,
Margherita Bignami, and David Livingston, for their essential input
as members of the Program Committee, and Ms. A. Toscani for her
invaluable assistance. The aid of the Savings Bank Cassa di
Risparmio di Trento e Ro- vereto, and the Municipal, Provincial,
and Regional Administrations in supporting this Symposium through
the Pezcoller Foundation are also acknowledged with deep apprecia-
tion. Finally, we wish to thank the staff of Plenum Publishing
Corporation for their effi- cient cooperation in the production of
these proceedings.
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