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The Sodium Pump - Structure Mechanism, Hormonal Control and its Role in Disease (Paperback, Softcover reprint of the original 1st ed. 1994)
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Discovery Miles 28 940
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The Sodium Pump - Structure Mechanism, Hormonal Control and its Role in Disease (Paperback, Softcover reprint of the original 1st ed. 1994)
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Total price: R2,914
Discovery Miles: 29 140
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The sodium of animal cell membranes converts the chemical energy
obtained from the hydrolysis of adenosine 5' -triphosphate into a
movement of the cations Na + and K + against an electrochemical
gradient. The gradient is used subse quently as an energy source to
drive the uptake of metabolic substrates in polar epithelial cells
and to use it for purposes of communications in excitable cells.
The biological importance of the sodium pump is evident from the
fact that be tween 20-70% of the cell's metabolic energy is
consumed for the pumping pro cess. Moreover, the sodium pump is an
important biological system involved in regulatory processes like
the maintenance of the cells' and organism's water me tabolism. It
is therefore understandable that special cellular demands are han
dled better by special isoforms of the sodium pump, that the
expression of the sodium pump and their isoforms is regulated by
hormones as is the activity of the sodium pump via
hormone-regulated protein kinases. Additionally, the sodium pump
itself seems to be a receptor for a putative new group of hormones,
the endogenous digitalis-like substances, which still have to be
defined in most cases in their structure. This group of substances
has its chemically well known coun terpart in steroids from plant
and toad origin which are generally known as "car diac glycosides."
They are in medical use since at least 200 years in medicine in the
treatment of heart diseases."
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