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Cryptorchidism - Ultrastructure of Normal and Cryptorchid Testis Development (Paperback)
Loot Price: R1,464
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Cryptorchidism - Ultrastructure of Normal and Cryptorchid Testis Development (Paperback)
Series: Advances in Anatomy, Embryology and Cell Biology, 53/3
Expected to ship within 10 - 15 working days
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Cytological techniques have greatly improved in the last twenty
years, largely as a result of further development of the
microscope. Electron microscopy, in particular, has opened up great
prospects for the study of cell morphology, while the develop ment
of radio-immuno-assay has brought great progress in endocrinology.
The applica tion of these two techniques, which are complementary
to each other and provide mutually supporting evidence, is the
subject of this monograph. The work is divided into two parts. The
first deals with the ultrastructure of normal testicular
development, describing four main elements of the testicle - the
germ cells, the Sertoli cells, the peri tubular connective tissue
and the Leydig cell- with details of their individual development.
To make the electron micrographs more easily understandable,
diagrams have been used to explain the most important points. The
second part deals with cryptorchid testicles, including the primary
and sec ondary changes involved and morphometric studies of the
secondary changes. The significance of these ultrastructural
observations for the treatment of cryptorchidism is emphasized.
With the aid of radio-immuno-assay the level of testosterone in
cryp torchid mice was determined and comparisons drawn between the
ultrastructural changes in cryptorchidism in mouse and man. The
experimental studies served as a basis for the hypothesis that, in
all probability, a congenital disturbance of the hy
pothalamo-hypophyso-gonadal axis is responsible for cryptorchidism.
I hope that this monograph will contribute towards a better
understanding of normal and cryptorchid testicular development and
of the etiology of cryptorchidism."
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