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Contemporary Topics in Immunochemistry - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1972)
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Contemporary Topics in Immunochemistry - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1972)
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In 1897, Ehrlich suggested that natural preformed receptors from
the surface of cells provided immunity to various chemical
substances. Many years later, in 1940, Pauling proffered the
concept that antibodies comprised a single poly peptide chain and
that each end of the protein could form an antigen-binding site.
Burnet tried to explain the diversity of antibody specificity by
hypothesizing that it was cell-derived. These hypotheses probably
have led to as much or more experimentation and discussion than any
other of the many conjectures set forth to explain immunity on a
molecular and cellular basis. Extensive investigations, initially
stimulated by these propositions, proved Pauling's notion
incorrect. In its demise, however, the multichain structure of the
immunoglobulins was realized. In retrospect it be comes obvious
that Ehrlich's idea, though not correct, was borne of amazing logic
and cognition. Expansion of Burnet's theory seems to be occurring
presently; much excitement is engendered by the finding of
cell-bound immunoglobulin receptors. Ouring the preceding dozen
years, immunochemists have accumulated enormous quantities of data.
Though there is so much yet to be done, as a result of this
research one may now discuss antigen-binding sites in relation to
the protein's primary structure. There is even considerable
understanding of the cellular assembly of some immunoglobulins.
Entire books can be written about the chemistry of antigens and of
complement."
General
Imprint: |
Springer-Verlag New York
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Country of origin: |
United States |
Release date: |
November 2012 |
First published: |
1972 |
Authors: |
F Inman
|
Dimensions: |
229 x 152 x 11mm (L x W x T) |
Format: |
Paperback
|
Pages: |
186 |
Edition: |
Softcover reprint of the original 1st ed. 1972 |
ISBN-13: |
978-1-4757-1345-9 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Diseases & disorders >
Immunology >
General
|
LSN: |
1-4757-1345-2 |
Barcode: |
9781475713459 |
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