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Contemporary Topics in Molecular Immunology - Volume 4 (Paperback, Softcover reprint of the original 1st ed. 1975)
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Contemporary Topics in Molecular Immunology - Volume 4 (Paperback, Softcover reprint of the original 1st ed. 1975)
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There are many unanswered questions regarding the molecular nature
of antibodies, components of complement, and other substances which
participate in the immune response. The list of substances which
need to be analyzed chemically is increasing. Plasma cell products,
of course, have long been of great interest because the most
prevalent ones are immunoglobulins. Other cell types, however, are
the source of the broad spectrum of additional substances which
classically fall into the sanctum of the molecular immunologist. It
is these substances, and especially those more recently discovered,
which are responsible for the broadening investigative interests of
immunologists. In this volume we have provided you with
descriptions of research being done with immunoglobulins and with
complement. Additionally, we have in cluded two reports that deal
with molecules which are among the more recent acquisitions of the
molecular immunologist. The components of complement are known to
react in a cascading manner which results in the lysis of cellular
antigens. The first step in the classical pathway requires the
activation of CI by the antibody-antigen aggregates. This volume of
Contemporary Topics in Molecular Immunology begins with the report
of Reid and Porter which describes their investigation of the
mechanism of activation of C I. Their descriptions of C I q and of
the reaction of C I with immunoglobulins are especially intriguing.
It is clearly apparent from their report that activation of the
components of complement is a complex phenome non.
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